Advanced Concentration

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Dissertation Research

Publications

Werden SJ, Lanchbury J, Shattuck D, Neff C, Dufford M, McFadden G. Myxoma virus M-T5 ankyrin-repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells. J Virol. 2009 Sep 23. [Epub ahead of print] PMID: 19776120  abstract

Mohamed MR, Rahman MM, Rice A, Moyer RW, Werden SJ, McFadden G.  Cowpox virus expresses a novel ankyrin repeat NF-kappaB inhibitor that controls inflammatory cell influx into virus-infected tissues and is critical for virus pathogenesis.  J Virol. 2009 Sep;83(18):9223-36. Epub 2009 Jul 1. PMID: 19570875  abstract

Barrett JW, Werden SJ, Wang F, McKillop WM, Jimenez J, Villeneuve D, McFadden G, Dekaban GA.  Myxoma virus M130R is a novel virulence factor required for lethal myxomatosis in rabbits.  Virus Res. 2009 Sep;144(1-2):258-65. Epub 2009 May 27. PMID: 19477207  abstract

Wang F, Gao X, Barrett JW, Shao Q, Bartee E, Mohamed MR, Rahman M, Werden S, Irvine T, Cao J, Dekaban GA, McFadden G.  RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.  PLoS Pathog. 2008 Jul 11;4(7):e1000099. PMID: 18617992  abstract

Werden SJ, Rahman MM, McFadden G.  Poxvirus host range genes.  Adv Virus Res. 2008;71:135-71. Review. PMID: 18585528  abstract

Stanford MM, Shaban M, Barrett JW, Werden SJ, Gilbert PA, Bondy-Denomy J, Mackenzie L, Graham KC, Chambers AF, McFadden G.  Myxoma virus oncolysis of primary and metastatic B16F10 mouse tumors in vivo.  Mol Ther. 2008 Jan;16(1):52-9. Epub 2007 Nov 13. PMID: 17998900  abstract

Nazarian SH, Rahman MM, Werden SJ, Villeneuve D, Meng X, Brunetti C, Valeriano C, Wong C, Singh R, Barrett JW, Xiang Y, McFadden G.  Yaba monkey tumor virus encodes a functional inhibitor of interleukin-18.  J Virol. 2008 Jan;82(1):522-8. Epub 2007 Oct 24. PMID: 17959666  abstract

Werden SJ, McFadden G.  The role of cell signaling in poxvirus tropism: the case of the M-T5 host range protein of myxoma virus. Biochim Biophys Acta. 2008 Jan;1784(1):228-37. Epub 2007 Aug 14. Review.  PMID: 17905673  abstract

Stanford MM, Werden SJ, McFadden G.  Myxoma virus in the European rabbit: interactions between the virus and its susceptible host.  Vet Res. 2007 Mar-Apr;38(2):299-318. Epub 2007 Feb 13. Review. PMID: 17296158  abstract

Barrett JW, Shun Chang C, Wang G, Werden SJ, Shao Z, Barrett C, Gao X, Belsito TA, Villenevue D, McFadden G.  Myxoma virus M063R is a host range gene essential for virus replication in rabbit cells.  Virology. 2007 Apr 25;361(1):123-32. Epub 2006 Dec 20. PMID: 17184804  abstract

Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G.  M-T5, the ankyrin repeat, host range protein of myxoma virus, activates Akt and can be functionally replaced by cellular PIKE-A.  J Virol. 2007 Mar;81(5):2340-8. Epub 2006 Dec 6. PMID: 17151107  abstract

Stanford MM, Barrett JW, Nazarian SH, Werden S, McFadden G.  Oncolytic virotherapy synergism with signaling inhibitors: Rapamycin increases myxoma virus tropism for human tumor cells.  J Virol. 2007 Feb;81(3):1251-60. Epub 2006 Nov 15. PMID: 17108021  abstract

Wang G, Barrett JW, Stanford M, Werden SJ, Johnston JB, Gao X, Sun M, Cheng JQ, McFadden G.  Infection of human cancer cells with myxoma virus requires Akt activation via interaction with a viral ankyrin-repeat host range factor.  Proc Natl Acad Sci USA. 2006 Mar 21;103(12):4640-5. Epub 2006 Mar 14. PMID: 16537421  abstract

Honors & Awards

UF Medical Guild Research Incentive Award, 2008