Advanced Concentration

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Education

B.Sc., Biology, Universidad de Extremadura, Badajoz (Spain)

Dissertation Research

Seetharaman SV, Prudencio M, Karch CM, Hollloway SP, Borchelt DR, Hart PJ. Immature Copper-zinc Superoxide Dismutase and Familial Amyotrophic Lateral Sclerosis Exp. Biol. Med.2009; 234(10):1140-1154. abstract

Prudencio M, Hart PJ, Borchelt DR, Andersen PM. Variation in aggregation rates by disease variants of SOD1: correlation to human disease. Hum. Mol. Genet.; 2009. 18(17):3217-3226. abstract

Karch CM, Prudencio M, Winkler DD, Hart PJ, Borchelt DR. Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS.  PNAS; 2009. 106(19):7774-7779. abstract

Prudencio M, Durazo A, Whitelegge J, Borchelt DR.  Modulation of mutant superoxide dismutase 1 aggregation by co-expression of wild-type enzyme. J. Neurochem.; 2009. 108(4):1009-18.abstract

Hofer T, Seo AY, Prudencio M, Leeuwenburgh C.  A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration. Biol Chem. 2006 Jan;387(1):103-11.  abstract

Prudencio M, Andersen PM, Borchelt DR. Variation in aggregate levels of disease-associated variants of SOD1: correlation to human disease. Poster presentation. FASEB Summer Research Conferences, Snowmass, CO. June 2009

Prudencio M, Borchelt DR Effect on ALS disease onset and aggregation of mutant SOD1 by co-expression of WT SOD1 protein. Poster presentation. College of Medicine Celebration of Research, University of Florida, Gainesville, FL. April 2009

Prudencio M. Implication of mutant SOD1 aggregates in familial ALS. Oral presentation. Mayo Clinic, Jacksonville, FL. April 2009

Prudencio M, Borchelt DR. Expression of human WT SOD1 slows aggregation of mutant SOD1, but eventually co-aggregates with mutant protein. Poster presentation. 40th Annual meeting of the American Society of Neurochemistry. Charleston, SC. March 2009

Prudencio M, Andersen PM, Borchelt DR. Variation in aggregate levels of disease-associated variants of SOD1: correlation to human disease. Poster presentation. 40th Annual meeting of the American Society of Neurochemistry. Charleston, SC. March 2009

Prudencio M. Variation in SOD1 aggregation rates: correlation to human disease. Graduate Neuroscience Seminar Series, McKnight Brain Institute at University of Florida, Gainesville, FL. January 2009

Prudencio M, Andersen P, Borchelt DR. Variation in aggregation by disease-associated variants of SOD1: correlation to human disease. Poster presentation. 4th Annual Symposium of the UF Genetics Insitute, University of Florida, Gainesville, FL. October 2008

Prudencio M, Durazo A, Whitelegge J, Borchelt DR. Modulation of aggregation of mutant superoxide dismutase 1 (SOD1) proteins by wild-type SOD1. Poster presentation.  4th Annual Symposia of Andre-Delambre Fundation on ALS.  Montreal Neurological Institute, McGill University, Montreal (Canada) September 2008

Mercedes Prudencio and David R. Borchelt.  Modulation of aggregation of mutant superoxide dismutase 1 (SOD1) proteins by wild-type SOD1.  College of Medicine Research Day, University of Florida, Gainesville.  April 23, 2008.

Mercedes Prudencio.  Aggregate formation and modulation in familial ALS: a cell culture approach.  Medical Guild Competition-Neuroscience. March 14, 2008.

Mercedes Prudencio. Modulation of mutant SOD1 aggregation in 293FT cells. PPG meeting, San Antonio, TX.  March 8-9, 2008.

Mercedes Prudencio. Modulation of mutant SOD1 aggregation by co-expression of WT and WT-like SOD1 variants. Graduate Seminar series, McKnight Brain Institute at University of Florida, Gainesville, FL, February 2008.

Mercedes Prudencio, Hilda Slunt and David R. Borchelt. Aggregation propensity of superoxide dismutase 1 (SOD1) mutants in familial amyotrophic lateral sclerosis: implication of interactions with wild-type SOD1. 37th Annual meeting of Society of Neuroscience, San Diego, CA, November 2-7, 2007.

Celeste M. Karch, Mercedes Prudencio, Hilda Slunt and David R. Borchelt. An assay to characterize superoxide dismutase 1 aggregation in familial amyotrophic lateral sclerosis. PERC Industrial Advisory Board Meeting, Hilton-University of Florida, Gainesville, October 8, 2007. Poster and snapshot presentation. NOTE: CMK and MP contributed equally to the elaboration of the poster.

Mercedes Prudencio, Hilda Slunt and David R. Borchelt. Aggregation propensity of superoxide dismutase 1 in a cell culture study of familial amyotrophic lateral sclerosis. Spring 2007 Graduate Student Council Forum, University of Florida, Gainesville, April 4, 2007.

Mercedes Prudencio, Hilda Slunt and David R. Borchelt. Aggregation propensity of superoxide dismutase 1 in a cell culture study of familial amyotrophic lateral sclerosis. College of Medicine Research Day, University of Florida, Gainesville, March 20, 2007.

Mercedes Prudencio. Aggregation propensity of Superoxide Dismutase 1 in familial amyotrophic lateral sclerosis. PPG meeting, UCLA, Los Angeles. March 15-18, 2007.

Mercedes Prudencio. Amyotrophic lateral sclerosis: superoxide dismutase 1 and protein aggregation. Sack Lunch Graduate Series, McKnight Brain Institute at University of Florida, Gainesville, FL, January 2007.

Honors & Awards

Outstanding International Student Award for the College of Medicine, University of Florida, Gainesville, FL, 2008