IDP Students


	Advanced Concentration	Neuroscience
	Mentor	David R. Borchelt, Ph.D.
	Department	Neuroscience
	Enrolled	August 2005
	Lab Room	L4-166
	Lab Phone	294-0582
	E-mail	merchepa@ufl.edu
Education
B.S., Biology, Universidad de Extremadura, Badajoz (Spain)
Dissertation Research
Implications of detergent insoluble aggregates of mutant SOD1 proteins in familial amyotrophic lateral sclerosis (ALS)

Publications
Hofer T, Seo AY, Prudencio M, Leeuwenburgh C. A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration. Biol Chem. 2006 Jan;387(1):103-11. abstract
Abstracts Presented at Meetings
Mercedes Prudencio and David R. Borchelt. Modulation of aggregation of mutant superoxide dismutase 1 (SOD1) proteins by wild-type SOD1. College of Medicine Research Day, University of Florida, Gainesville. April 23, 2008.
Mercedes Prudencio. Aggregate formation and modulation in familial ALS: a cell culture approach. Medical Guild Competition-Neuroscience. March 14, 2008.
Mercedes Prudencio. Modulation of mutant SOD1 aggregation in 293FT cells. PPG meeting, San Antonio, TX. March 8-9, 2008.
Mercedes Prudencio. Modulation of mutant SOD1 aggregation by co-expression of WT and WT-like SOD1 variants. Graduate Seminar series, McKnight Brain Institute at University of Florida, Gainesville, FL, February 2008.
Mercedes Prudencio, Hilda Slunt and David R. Borchelt. Aggregation propensity of superoxide dismutase 1 (SOD1) mutants in familial amyotrophic lateral sclerosis: implication of interactions with wild-type SOD1. 37th Annual meeting of Society of Neuroscience, San Diego, CA, November 2-7, 2007.
Celeste M. Karch, Mercedes Prudencio, Hilda Slunt and David R. Borchelt. An assay to characterize superoxide dismutase 1 aggregation in familial amyotrophic lateral sclerosis. PERC Industrial Advisory Board Meeting, Hilton-University of Florida, Gainesville, October 8, 2007. Poster and snapshot presentation. NOTE: CMK and MP contributed equally to the elaboration of the poster.
Mercedes Prudencio, Hilda Slunt and David R. Borchelt. Aggregation propensity of superoxide dismutase 1 in a cell culture study of familial amyotrophic lateral sclerosis. Spring 2007 Graduate Student Council Forum, University of Florida, Gainesville, April 4, 2007.
Mercedes Prudencio, Hilda Slunt and David R. Borchelt. Aggregation propensity of superoxide dismutase 1 in a cell culture study of familial amyotrophic lateral sclerosis. College of Medicine Research Day, University of Florida, Gainesville, March 20, 2007.
Mercedes Prudencio. Aggregation propensity of Superoxide Dismutase 1 in familial amyotrophic lateral sclerosis. PPG meeting, UCLA, Los Angeles. March 15-18, 2007.
Mercedes Prudencio. Amyotrophic lateral sclerosis: superoxide dismutase 1 and protein aggregation. Sack Lunch Graduate Series, McKnight Brain Institute at University of Florida, Gainesville, FL, January 2007.


Honors & Awards
Short-term research scholarship funded by the Ministry of Education and Science, Spain, 2005.