Fundamentals of Biomedical Science I (GMS 6001) and First Year Fall Schedule

Course Director: Jim Resnick, Ph.D.

Section Leaders: Art Edison, Ph.D. (Biochemistry), Jim Resnick, Ph.D. (Genetics), Bill Dunn, Ph.D. and Jeff Harrison, Ph.D. (Cell Biology/Signal Transduction)

Course Syllabus

Discussion Groups

Shown below is a table displaying the dates and titles for all of the Lectures (“L”), Discussions (“D”), Team-Based Learning (“TBL”), Grand Rounds (“GR”), Tours , Exams & Reviews. Also included on this schedule are meetings for the course GMS 6003, Essentials of Graduate Research & Professional Development which are in bold. Sections are delineated with bold subheadings, and weeks are separated with blank rows. For course content, please click on the lecture title.

Course evaluations are maintained in the College of Medicine Medinfo Courses course management system. You will need to log in with your Gatorlink username and password.

Text books: Voet & Voet Biochemistry, 4th Edition; Lodish et al., Molecular Cell Biology, 7th Edition; Griffiths et al., An Introduction to Genetic Analysis, 10th Edition.

Day Date Time Room   Title Instructors
W 14-Aug 8:30-10:15 Reitz Union   Graduate Student Orientation  
W 14-Aug 10:30-12:00 Reitz Union   International Graduate Student Orientation  
T 14-Aug 10:15-11:15 C2-3   HSC Library Orientation (last names A-K) M Tennant
T 14-Aug 11:45-12:45 C2-3   HSC Library Orientation (last names L-Z) M Tennant
T 14-Aug 2:00-3:00 C1-4   Radiation Safety Short Course-Introduction Susan Stanford
T 14-Aug 3:00-4:00 C1-4   Radiation Safety Short Course-Fundamentals Radiation Concepts  
T 14-Aug 5:00-7:00 Biomedical Sciences Building Atrium IDP Welcome Reception  
W 15-Aug 10:00-12:30 C2-3   Database Searching Workshop (last names A-K) M Tennant
W 15-Aug 1:00-3:30 C2-3   Database Searching Workshop (last names L-Z) M Tennant
W 15-Aug 3:30-5:00 LG-110   Student Introductions W McCormack
Th 16-Aug 10:00-11:30 C1-7   UF Chemical Hygiene Program (CHP) & Chemical Safety M Yanchisin
Th 16-Aug 2:00-3:00 C1-7   Radiation Safety Short Course-Radiation Detectors & Survey Instruments Susan Stanford
Th 16-Aug 3:00-4:00 C1-7   Radiation Safety Short Course-Radioisotope Laboratory Techniques Susan Stanford
F 17-Aug 10:00-10:45 C1-4   Radiation Safety Short Course-Radiation Protection Les Hines
F 17-Aug 10:45-11:30 C1-4   Radiation Safety Short Course-Biological Effects of Ionizing Radiation Les Hines
F 17-Aug 11:30-12:00 C1-4   Radiation Safety Short Course-Radioactive Waste Bill Coughlin
F 17-Aug 1:00-3:00 C1-7   Biological Safety, Blood-Borne Pathogens, Animal Contact Program K Gillis
             
Biochemistry & Molecular Biology
Day   Time Room   Title Instructors
             
M 20-Aug 9:00-12:00 R5-265   At the Bench – Problem Solving 1 McCormack/Norton
M 20-Aug 1:00-2:00 R5-265   Listening to Learn McCormack
T 21-Aug 9:00-12:00 R5-265   At the Bench – Problem Solving 2 McCormack/Norton
T 21-Aug 1:00-2:00 R5-265   Selecting a Mentor & Dissertation Project Gulig
W 22-Aug 8:30-8:40 C1-7   Introduction Edison
W 22-Aug 8:40-9:20 C1-7   Principles of Evolution and Comparative Approaches in Biomedicine Moroz
W 22-Aug 9:35-10:25 C1-7   Diversity of Life: Introduction into Major Groups and Model Organisms Moroz
W 22-Aug 11:00-4:00 R5-265   Advanced Program & Faculty Presentations  
Th 23-Aug 8:30-10:25 MBI lobby   AMRIS and X-Ray crystalography facility tours Mareci/McKenna
Th 23-Aug 11:00-4:00 R5-265   Advanced Program & Faculty Presentations  
Th 23-Aug 4:00-5:00 LG-110   Life in the Lab Condit
F 24-Aug 8:30-9:20 C1-7   Primary Structure, amino acids, and peptides Edison
F 24-Aug 9:35-10:25 C1-7   Secondary Structure:  alpha helix, beta sheet, and turns Edison
F 24-Aug 11:00-4:00 R3-265   Advanced Program & Faculty Presentations  
             
M 27-Aug 8:30-9:20 C1-7   Tertiary Structure: Folds and Structure Classification Edison
M 27-Aug 9:35-10:25 C1-7   Quaternary Structure:  Macromolecular complexes Edison
M 27-Aug 11:00-4:00 R5-265   Advanced Program & Faculty Presentations  
T 28-Aug 8:30-9:45 C2-42    “Epigenetics in the Extreme: Prions and the Inheritance of Environmentally Acquired Traits”, Halfmann and Lindquist, SCIENCE 330, pp. 629-32, 2010. Lauren Gay
T 28-Aug 8:30-9:45 C2-43   Chaevien Clendinen
T 28-Aug 8:30-9:45 C2-44   Jennifer Lyles
T 28-Aug 8:30-9:45 CG-49   Stephan Jahn
W 29-Aug 8:30-9:20 C1-7   Membrane Proteins: Structural aspects and experimental challenges Edison
W 29-Aug 9:35-10:25 C1-7   Protein folding and Chaperones Edison
Th 30-Aug 8:30-9:45 C1-7   Enzyme Mechanisms Purich
Th 30-Aug 8:30-9:45 C1-7   Enzyme Inhibition Purich
Th 30-Aug 4:00-5:00 LG-110   Career Development Seminar:
Peter Sayeki, Ph.D.
“An Academic Career: How Did I Get Here and What Do I Do?”

Associate Professor, Department of Physiology and Functional Genomics
 
F 31-Aug 8:30-9:20 C1-7   Enzyme Kinetics – dose response Purich
F 31-Aug 9:35-10:25 C1-7   Structure-based (rational) design of enzyme-directed drugs Purich
             
M 3-Sep Labor Day Holiday – No Classes  
T 4-Sep 8:30-9:45 C2-42    ”Four generations of transition-state analogues for human purine nucleoside phosphorylase”, Ho et al., PNAS 107, pp. 4805–4812 (2010).” Lauren Gay
T 4-Sep 8:30-9:45 C2-43   Chaevien Clendinen
T 4-Sep 8:30-9:45 C2-44   Jennifer Lyles
T 4-Sep 8:30-9:45 CG-49   Stephan Jahn
W 5-Sep 8:30-10:25 C1-7   Nucleic Acid Structure: DNA & RNA Bungert
Th 6-Sep 8:30-10:25 C2-3   Computer–based learning:  Introduction to PyMOL Edison
Greg Stupp
Brittany Lee
Scott Harden
Th 6-Sep 4:00-5:00 LG-110   How to Read a Scientific Paper Condit
Fr 7-Sep 8:30-9:20 C1-7   HTP seq techniques  (ChipSeq and RNASeq, etc.) R Renne
Fr 7-Sep 9:35-10:25 C1-7   HTS Analysis L Zhou
Fr 7-Sep 10:40-12:00 C1-7   Review All lectures
             
M 10-Sep       Rotation 1 begins  
M 10-Sep 8:30-11:30 LG-101   EXAM 1  
T 11-Sep 8:30-10:25 CGRC Lobby   ICBR tour Farmerie
W 12-Sep 8:30-10:25 C1-7   Chromatin, Chromosome, Genome Structure   backup Yang
Th 13-Sep 8:30-10:25 C2-3   Computer–based learning:  Introduction to MatLab
Additional exercises
Notes    backup
Edison
Greg Stupp
Brittany Lee
Scott Harden
Th 13-Sep 4:00-5:00 LG-110   Introduction to Research Design Bloom
Fr 14-Sep 8:30-9:20 C1-7   DNA Replication I & II   backup Bloom
             
M 17-Sep 8:30-9:20 C1-7   DNA Replication III    backup Bloom
M 17-Sep 9:35-10:25 C1-7   DNA base damage and repair    Outline
backup
Brown
T 18-Sep 8:30-9:45 C1-7   Structural Biology of AAV to Improve Gene Therapy    backup Agbandje-McKenna
W 19-Sep 8:30-9:20 C1-7   DNA strand breaks and repair    Outline
backup
Brown
W 19-Sep 9:35-10:25 C1-7   Protein/DNA interactions    backup Bungert
Th 20-Sep 8:30-9:45 C2-3   Computer–based learning: Basics of Data Analysis  backup Edison
Greg Stupp
Brittany Lee
Scott Harden
Th 20-Sep 4:00-5:00 LG-110   Career Development Seminar
Panel Discussion: “Ask a Postdoc”
 
Fr 21-Sep 8:30-9:20 C1-7   Gene  and Promoter Structure    backup Bungert
Fr 21-Sep 9:35-10:25 C1-7   Transcription:  Prokaryotes    backup Bungert
             
M 24-Sep 8:30-9:20 C1-7   Transcription:  Eukaryotes I & II   backup Bungert
T 25-Sep 8:30-9:45 C2-42   1) “High-Resolution Profiling of Histone Methylations in the Human Genome”, Barski et al., Cell 129, pp. 823–837, 2007 and 2) “Characterization of human epigenomes”,Wang et al., Current Opinion in Genetics & Development 19, pp. 127-34, 2009.

Paper I backup
Paper II backup
Lauren Gay
T 25-Sep 8:30-9:45 C2-43   Chaevien Clendinen
T 25-Sep 8:30-9:45 C2-44   Jennifer Lyles
T 25-Sep 8:30-9:45 CG-42   Stephan Jahn
W 26-Sep 8:30-9:20 C1-7   RNA Interference (include microRNA)   backup Harfe
W 26-Sep 9:35-10:25 C1-7   Non-coding RNA   backup Bungert
Th 27-Sep       Self Study
Th 27-Sep 4:00-5:00 LG-110   The Grants that Fund your Research   Siemann
Fr 28-Sep 8:30-9:20 C1-7   RNA Processing:  Splicing I (basic) & II (alternative)              Paper
backup
M Swanson
             
M 1-Oct 8:30-9:20 C1-7   Protein Synthesis I & II   backup J Bungert
T 2-Oct       Self Study  
W 3-Oct 8:30-10:25 C1-7   Review  
Th 4-Oct       Self Study  
Th 4-Oct 4:00-5:00 LG-110   Oral Presentation Skills Condit
Fr 5-Oct 8:30-11:30 C1-7   Exam 2  
             
Genetics          
M 8-Oct 8:30-9:20 C1-7   Introduction  Solutions: Ch. 2, Ch. 3, Ch. 4, Ch. 6, Ch. 12, Ch. 19 J Resnick
M 8-Oct 8:30-9:20 C1-7   Chromosomes, Meiosis and Mendel’s Laws J Resnick
M 8-Oct 9:35-10:25 C1-7   Mendelian Inheritance, Recombination, Linkage J Resnick
T 9-Oct 8:30-9:45 C2-42   Recombination mapping in drosophila           Discussion Paper Guide Lauren Gay
T 9-Oct 8:30-9:45 C2-43   Chaevien Clendinen
T 9-Oct 8:30-9:45 C2-44   Jennifer Lyles
T 9-Oct 8:30-9:45 CG-42   Stephan Jahn
W 10-Oct 8:30-9:20 C1-7   Physical Maps J Resnick
W 10-Oct 9:35-10:25 C1-7   Analysis of Mutants J Resnick
Th 11-Oct 8:30-10:25 C2-3 CBL Gennotes
Punnett
Greg’s website and contact info
 
Th 11-Oct 4:00-5:00 LG-110   Bumps in the Road
Gulig
Fr 12-Oct 8:30-9:20 C1-7   Mutation and Cancer Genetics J Resnick
Fr 12-Oct 9:35-10:25 C1-7   Population Genetics M Wallace
             
M 15-Oct 8:30-9:20 C1-7   Genomics       Baker
M 15-Oct 9:35-10:25 C1-7   Cytogenetics Driscoll
T 16-Oct 8:30-10:25 C1-7   Student Seminar Ron Batra
T 16-Oct 11:45 R3-265   Biochemistry & Molecular Biology Concentration Presentations  
T 16-Oct 1:00-2:30 R5-265   Physiology & Pharmacology Concentration Presentations  
W 17-Oct 8:30-10:25 C1-7   Mouse I & II J Resnick
W 17-Oct 12:00-1:00 R5-265   Molecular Cell Biology Concentration Rotation Presentations  
W 17-Oct 3:50-5:00 CGRC 451   Genetics Concentration Rotation Presentations  
Th 18-Oct 8:30-10:25 R5-265 TBL    
Th 18-Oct 12:00-3:00 LG-101   Neuroscience Concentration Rotation Presentations  
Th 18-Oct 12:00 R2-265   Immunology & Microbiology Rotation Presentations  
Th 18-Oct 4:00-5:00 LG-110   Career Development Seminar (PowerPoint)
 Ann Griswold, Ph.D
Fr 19-Oct       Rotation 1 ends  
Fr 19-Oct 8:30-9:20 C1-9   Nonmendelian Inheritance J Resnick
Fr 19-Oct 9:35-10:25 C1-9   Genetic Imprinting                        J Resnick
Fr 19-Oct 10:30-12:00 C1-9   Review           2011 Genetics Exam-KEY  
             
M 22-Oct       Rotation 2 begins  
M 22-Oct 8:30-11:30 C1-9   Exam 3  
Cellular Structure and Signaling      
T 23-Oct 10:00-11:00 R5-265   “Signaling protein/molecular docking – pre-meeting”  
W 24-Oct 8:30-9:20 C1-7   Plasma membrane J Aris
W 24-Oct 9:35-10:25 C1-7   Introduction to Cell Signaling: Overview of Pathways J Harrison
Th 25-Oct 8:30-9:20 C1-7   Techiques (Antibody Methodology) W Dunn
Th 25-Oct 9:35-10:25 C1-7   Techiques (Imaging & Organelle Isolation) W Dunn
Th 25-Oct 4:00-5:00 LG-110   How to Publish Siemann 
Fr 26-Oct 8:30-10:25 C1-7   G-protein Coupled Signaling I & II J Harrison
             
M 29-Oct 8:30-10:25 C1-7   Receptor Tyrosine Kinases/MAPK/AKT:PI3K I & II G Shaw
T 30-Oct 8:30-10:30 R3-265 TBL Candidate signaling protein and molecular docking team presentations  
W 31-Oct 8:30-9:20 C1-7   Cytoskeleton networks    Objectives S Holliday
W 31-Oct 9:35-10:25 C1-7   Cytoskeleton networks      Objectives S Holliday
Th 1-Nov 8:30-10:25 C2-3 CBL Molecular docking/Signaling demo  
Th 1-Nov 4:00-5:00 LG-110   Bumps in the Road Gulig 
Fr 2-Nov 8:30-9:20 C1-7   Cell – Cell junctions and the cytoskeleton   Objectives S Holliday
Fr 2-Nov 9:35-10:25 C1-7   Cell – Matrix interactions           Objectives S Holliday
             
M 5-Nov 8:30-9:20 C1-7   Peroxisomes and Mitochondria W Dunn
M 5-Nov 9:35-10:25 C1-7   Vesicular Trafficking J Aris
T 6-Nov 8:30-10:25 C2-42  

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis 

Objectives

Lauren Gay
T 6-Nov 8:30-10:25 C2-43   Chaevien Clendinen
T 6-Nov 8:30-10:25 C2-44   Jennifer Lyles
T 6-Nov 8:30-10:25 CG-42   Stephan Jahn
W 7-Nov 8:30-9:20 C1-7   Endocytosis W Dunn
W 7-Nov 9:35-10:25 C1-7   Lysosome W Dunn
Th 8-Nov 8:30-9:20 C1-7   Nucleus I A Ishov
Th 8-Nov 9:35-10:25 C1-7   Nucleus II A Ishov
Th 8-Nov 4:00-5:00 LG-110   Working with your Mentor & Supervisory Committee McCormack
Fr 9-Nov UF Homecoming – NO Classes        
             
M 12-Nov Veteran’s Day – NO Classes        
T 13-Nov 8:30-9:20 C1-7 GR Lysosomal Storage Disease: Pompe Disease Dr. Barry Byrne
T 13-Nov 9:35-10:25 CG-49   Medina, et al. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. 2011. Dev. Cell 21, 421-30. Lauren Gay
T 13-Nov 9:35-10:25 R2-215   Chaevien Clendinen
T 13-Nov 9:35-10:25 R3-265   Jennifer Lyles
T 13-Nov 9:35-10:25 C1-7   Stephan Jahn
W 14-Nov 8:30-9:20 C1-7   Compartmentalization of cellular metabolism (ROS Production) Anna-Maria Joseph
W 14-Nov 9:35-10:25 C1-7   Compartmentalization of cellular metabolism (ROS Degradation) Anna-Maria Joseph
Th 15-Nov 8:30-9:20 C1-17   NL  
Th 15-Nov 9:35-10:25 C1-17   NL  
Th 15-Nov 4:00-5:00 LG-110   Career Development Seminar
Alison Bawden, Ph.D.,
Entrepreneurship & Biotech Startup Companies
 
Fr 16-Nov 8:30-10:25 C1-7   Review  
             
M 19-Nov 8:30-11:30 C1-7   Exam 4  
T 20-Nov 8:30-10:25 C1-7   Protein Synthesis III: free polyribosomes/Protein Synthesis IV: membrane-bound polyribosomes J Aris
             
W 21-23 Nov Thanksgiving Break – NO Classes        
             
M 26-Nov 8:30-10:25 C1-7   Protein Synthesis V: regulation and quality control/Protein Secretion J Aris
T 27-Nov 8:30-9:20 C1-7 GR Alpha1-antitrypsin deficiency, a disease of the liver and lungs Dr. Mark Brantly
T 27-Nov 9:35-10:25 C2-42   Duan, et al. ER stress negatively modulates the expression of the miR-199a/214 cluster to regulate tumor survival and progression in human hepatocellular cancer.  2012. PLOS One Lauren Gay
T 27-Nov 9:35-10:25 C2-43   Chaevien Clendinen
T 27-Nov 9:35-10:25 C2-44   Jennifer Lyles
T 27-Nov 9:35-10:25 CG-42   Stephan Jahn
W 28-Nov 8:30-9:20 C1-7   Protein turnover: Proteosome W Dunn
W 28-Nov 9:35-10:25 C1-7   Protein turnover: Autophagy W Dunn
W 28-Nov 12:00 R5-265   Molecular Cell Biology Rotation Presentations  
Th 29-Nov 8:30-10:25 C1-7 CBL Imaging and Image Processing  
Th 29-Nov 4:00-5:00 LG-110   Life of a Graduate Student – Faculty Stories Siemann
Fr 30-Nov 8:30-10:25 C1-7   Cell Cycle: regulation/Mitosis versus Meiosis K Brown
             
M 3-Dec 8:30-9:20 C1-7   Organization of cells into tissues: epithelium, connective, muscle, nerve W Dunn
M 3-Dec 9:35-10:25 C1-7   Cell polarity and tissue function W Dunn
T 4-Dec 8:30-10:25 R2-265 TBL Protein Homeostasis W Dunn and J Aris
T 4-Dec 11:45 R3-265   Biochemistry & Molecular Biology Rotation Presentations  
W 5-Dec 8:30-9:20 C1-7   Epithelium Homeostasis W Dunn
W 5-Dec 9:35-10:25 C1-7   Mechanisms of Cell Death W Dunn
W 5-Dec 11:30-1:15 R5-265   Physiology & Pharmacology Rotation Presentations  
W 5-Dec 3:00 CGRC 451   Genetics Rotation Presentations  
Th 6-Dec 8:30-10:25 C1-7   Development of tissues I & II J Aris
Th 6-Dec 12:00 R2-265   Immunology & Microbiology Rotation Presentations  
Th 6-Dec 2:00-3:00 LG-101   Research Seminar
Katherine A. High, MD, William H. Bennett Professor of Pediatrics, Department of Pediatrics, University of Pennsylvania,  Perelman School of Medicine
Sponsored by Department of Biochemistry & Molecular Biology
 
Th 6-Dec 4:00-5:00 LG-110   *CANCELLED*
Career Development Seminar
Cindy Prins, Ph.D., MPH, CIC, CPH, Clinical Assistant Professor
Public Health and Health Professions: Dept.of Epidemiology
 
Fr 7-Dec       Rotation 2 ends  
Fr 7-Dec 8:30-10:25 C1-7   Review  
Fr 7-Dec 11:00-2:30 LG-110B   Neuroscience Rotation Presentations  
             
M 10-Dec 8:30-11:30 C1-7   Exam 5