Course Director: Marieta Heaton
Synopsis: This course will consider the development of the central and the peripheral nervous systems, from both molar and molecular perspectives. Topics will include homeotic and neurogenic genes, the development of nervous system polarity, molecular mechanisms of neuronal migration and cellular positioning, the mode and mechanisms of neural crest migration and differentiation, cell death and survival during nervous system development, the role of neurotrophic factors in nervous system development, the molecular biology of axonal guidance, neuronal specificity and specific pattern formation, gliogenesis, development of cerebral and cerebellar cortex, cell lineage, and the role of experience and neuronal activity in nervous system development. In addition, attention will be given to abnormalities seen in nervous system development in humans and animal models, and the mechanisms underlying these abnormalities.
Time Offered: Fall