Course Director: Marguerite Hatch (hatchma@pathology.ufl.edu)
3rd Module
Mon,Wed,Fri 9:35-10:25 am
Room D6-10
This 16 lecture-discussion module is structured to introduce students to the integration between basic and clinical research on the cellular and molecular pathogenesis of liver diseases. The course will provide students with an overview of the natural history of selected human diseases, their diagnosis and clinical management (bench to bedside theory). This will be followed by in-depth discussions concerning the pathology of liver diseases, with particular attention focused on both the cellular and molecular mechanisms involved in the progression of these diseases.
Dr. B. Petersen
1. Basic liver physiology and pathobiology (Nov 3rd)
2. Liver regeneration (Nov 5th)
3. Cirrhosis/alcoholic liver disease (Nov 10th)
4. Clinical treatment of alcoholic liver disease (Nov 12th)
Dr. B. Goldberger
5. Pharmacogenomics and drug toxicity (Nov 14th)
Dr. J. Scornik
6. Liver Transplantation (Nov 17th)
Dr. C. Liu
7. Cytokines and liver diseases (Nov 19th)
8. Liver and the immune system (Nov 21st)
10. The pathogenesis of viral hepatitis (Nov 24th)
11. Liver cancer: etiology and pathology (Nov 26th)
Dr. M. Hatch
12. Primary Hyperoxaluria: A genetically based liver disease (Dec 1st)
13. The ramifications of Primary Hyperoxaluria: An overview of multiorgan effects (Dec 3rd)
14 Molecular Basis of Alpha-1-Antitrypsin Deficiency (Dec 5th, Dr. Mark Brantly)
15. Discussions on liver diseases, part I (Dec 8th)
16. Discussions on liver diseases, part II. (Dec 10th)
Grading criteria: This module will consist of 14 lectures. Two lecture periods (#15- #16) are reserved for individual student presentations. Each topic will have publication references and reading materials which will be handed out prior to the lecture series. Grading (a letter grade) will be based on the combined assessment of (i) a 60 minute written exam (multiple choice/short essay exam on Dec 15th), (ii) class participation throughout the lecture period (Nov 3rd – Dec 5th), in addition to (iii) short presentations (~15 min) made by each student on a specific liver disease (Dec 8th and 10th).