Course Organizer: R. McKenna & M.Agbandje-McKenna
Course Description: 1-2 credit, Fall semester
Objective is to provide detailed theoretical and practical instructions
on the methodology of X-ray
crystallography. Students will learn the theory behind the technique
of X-ray crystallography and will
apply the knowledge obtained to the three-dimensional structure determination
of a macromolecule (
lysozyme). The laboratory class will provide practical experience in
sample preparation, operation of
the instrumentation, data acquisition, data analysis, phasing and refinement.
The anticipation is that
students will take both the theoretical and practical sections of the
course for 2 credits, which will run
concurrently. However, students may earn 1 credit by either attending
the lectures on the theory of
X-ray crystallography or the laboratory class. This hands-on approach
will reinforce the applicability of
this methodology in the analysis of the functional properties of a
biological macromolecule.
15 hours of lectures on X-ray crystallography
15 hour of lab/applications