Advanced Concentration

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B.S., Sungkyunkwan University, S Korea - Genetic Engineering

Modulation of mitochondrial dynamics during the aging process: the effects of calorie restriction

Seo AY, Xu J, Servais S, Hofer T, Marzetti E,  Wohlgemuth S, Knutson MD, Leeuwenburgh C. (2008) Mitochondrial iron accumulation with age and functional consequences. Aging Cell, 7, 706-716.

Chung HY, Cesari M, Anton S, Marzetti E, Manini TM, Seo AY, Giovannini S, Leeuwenburgh C. Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev. In press. abstract

Chung JH, Seo AY, Chung SW, Kim MK, Leeuwenburgh C, Yu BP, Chung HY. (2008) Molecular mechanism of PPAR in the regulation of age-related inflammation. Ageing Res Rev., 7, 126-136. abstract

Tim Hofer, Emanuele Marzetti, Arnold Y. Seo, Jinze Xu, Mitchell D, Christiaan Leeuwenburgh. (2008) Mechanisms of iron regulation and oxidative stress in sarcopenia and neurodegenerative diseases. Research Signpost., In press (Book Chapter).

Hofer, T., Marzetti, E., Xu, J., Seo, A. Y., Gulec, S., Knutson, M. D., Leeuwenburgh, C., Dupont-Versteegden, E. E. (2008) Increased RNA oxidative damage and iron content in skeletal muscle with aging and disuse atrophy. Exp.Gerontol. 43, 563-570. abstract

Marzetti E, Lawler JM, Hiona A, Manini T, Seo AY, Leeuwenburgh C. (2008) Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle. Free Radic Biol Med., 44, 160-168. abstract

Carter CS, Hofer T, Seo AY, Leeuwenburgh C. (2007) Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention. Appl. Physiol. Nutr. Metab., 32, 954-966. abstract

Sanz A, Hiona A, Kujoth GC, Seo AY, Hofer T, Kouwenhoven E, Kalani R, Prolla TA, Barja G and Leeuwenburgh C (2007). Evaluation of gender differences on mitochondrial bioenergetics and apoptosis in mice. Exp. Gerontol., 42, 173-182. abstract

Seo AY, Hofer T, Sung B, Judge S, Chung AY and Leeuwenburgh C. (2006) Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise. Antioxid. Redox Signal., 8, 529-538. abstract

Hofer T, Seo AY, Prudencio M and Leeuwenburgh C (2006). Method to determine RNA and DNA oxidation simultaneously by HPLC-ECD; greater RNA than DNA oxidation in rat liver from doxorubicin administration. Biol. Chem. 387, 103-111. abstract

Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth S, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow J, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, Weindruch R, Leeuwenburgh C and Prolla TA (2005) Mitochondrial DNA mutations, oxidative stress and apoptosis in mammalian aging. Science, 309, 481-484. abstract

Hofer T, Marzetti E, Seo AY, Servais S, Knutson MD, Leeuwenburgh C and Dupont-Versteegden EE. Increased RNA oxidative damage in skeletal muscle with aging and disuse atrophy. 13th Biennial meeting of the International Society for Free Radical Research (SFRR), Davos, Switzerland, August 15-19. Free Radical Res., 40, Suppl. 1. p S83.(2006)

Hiona A, Sanz A, Kujoth G, Seo AY, Kalani R, Hofer T, Kouwenhoven E, Servais S, Prolla T, Leeuwenburgh C Mitochondrial DNA mutations cause mitochondrial dysfunction without increasing oxidative stress. 35th Annual Meeting of the American Aging Association, Boston, MA. (2006)

Judge S, Seo AY, Hofer T, Kalani R, Jang YM, Selman C, Phillips T, Prudencio M, Carter C, Pahor M, Sung B, Chung HY, Kim JH, Kwak HB, Lawler J, Smith A, Hagen T, Speakman JR, Leeuwenburgh C Effects of Lifelong Exercise and 8% Caloric Restriction on Free Radical Biology. 35th Annual Meeting of the American Aging Association, Boston, MA. (2006)

American Heart Association Pre-Doctoral Fellowship, Florida/Puerto Rico Affiliate, 2006-2008