Philip O. Scumpia

Advanced Concentration

Immunology & Microbiology

Mentor

Michael J. Clare-Salzler, M.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 2004

Lab Room

D11-38

Lab Phone

392-4887

E-mail

pscumpia@ufl.edu

Education

B.S., Microbiology, University of Florida

Dissertation Research

Publications

Kelly-Scumpia KM, Nacionales DC, Scumpia PO, Weinstein JS, Narain S, Moldawer LL, Satoh M, Reeves WH. In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen. Arthritis Rheum. 2007 Oct;56(10):3379-86.  abstract

Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007 Nov 15;110(10):3673-81.  abstract

Wynn JL, Scumpia PO, Delano MJ, O'malley KA, Ungaro R, Abouhamze A, Moldawer LL. INCREASED MORTALITY AND ALTERED IMMUNITY IN NEONATAL SEPSIS PRODUCED BY GENERALIZED PERITONITIS. Shock. 2007 Jul 5; [Epub ahead of print]  abstract

Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med. 2007 Jun 11;204(6):1463-74.  abstract

Uchida T, Scumpia PO, Murasko DM, Seki S, Woulfe S, Clare-Salzler MJ, Moldawer LL.  Variable Requirement of Dendritic Cells for Recruitment of NK and T Cells to Different TLR Agonists. J Immunol. 2007 Mar 15;178(6):3886-92.  abstract

Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL.  Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol. 2006 Dec 1;177(11):7943-9.  abstract

Matsumoto T, O'Malley K, Efron PA, Burger C, McAuliffe PF, Scumpia PO, Uchida T, Tschoeke SK, Fujita S, Moldawer LL, Hemming AW, Foley DP.  Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning. Surgery. 2006 Nov;140(5):793-802.  abstract

Sethu P, Moldawer LL, Mindrinos MN, Scumpia PO, Tannahill CL, Wilhelmy J, Efron PA, Brownstein BH, Tompkins RG, Toner M.  Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis. Anal Chem. 2006 Aug 1;78(15):5453-61.  abstract

Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH.  "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60. Arthritis Rheum. 2006 May;54(5):1557-67.  abstract

Lee PY, Scumpia PO, Byars JA, Kelly KM, Zhuang H, Shuster JS, Theriaque DW, Segal MS, Reeves WH, Brantly ML.  Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.  Vaccine. 2006 Jan 9; [Epub ahead of print] abstract

McAuliffe PF, Efron PA, Scumpia PO, Uchida T, Mutschlecner SC, Rout WR, Moldawer LL, Cendan JC.  Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery.  Obes Surg. 2005 Nov-Dec;15(10):1424-31. abstract

Scumpia PO, Moldawer LL. Biology of interleukin-10 and its regulatory roles in sepsis syndromes.  Crit Care Med. 2005 Dec;33(12 Suppl):S468-71. Review. No abstract available.

McAuliffe PF, Murday ME, Efron PA, Scumpia PO, Ungaro R, Abouhamze A, Tannahill CL, Hutchins B, LaFace D, Moldawer LL. Dose-dependent improvements in outcome with adenoviral expression of interleukin-10 in a murine model of multisystem organ failure.  Gene Ther. 2006 Feb;13(3):276-82. abstract

Scumpia PO, McAuliffe PF, O'malley KA, Ungaro R, Uchida T, Matsumoto T, Remick DG, Clare-Salzler MJ, Moldawer LL, Efron PA. CD11c+ Dendritic Cells Are Required for Survival in Murine Polymicrobial Sepsis. J Immunol. 2005 Sep 1;175(5):3282-6. abstract

Tsujimoto H, Uchida T, Efron PA, Scumpia PO, Verma A, Matsumoto T, Tschoeke SK, Ungaro RF, Ono S, Seki S, Clare-Salzler MJ, Baker HV, Mochizuki H, Ramphal R, Moldawer LL. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. J Leukoc Biol. 2005 Jul 20; [Epub ahead of print] abstract

Scumpia PO, Kelly KM, Reeves WH, Stevens BR. Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes. Glia. 2005 May 26; [Epub ahead of print] abstract

Oberholzer A, Oberholzer C, Efron PA, Scumpia PO, Uchida T, Bahjat K, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Tsai V, Hutchins B, Moldawer LL, Laface D, Clare-Salzler MJ. Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis. Shock. 2005 Jun;23(6):507-15. abstract

Liboni KC, Li N, Scumpia PO, Neu J. Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium. J Nutr. 2005 Feb;135(2):245-51. abstract

Demarco VG, Scumpia PO, Bosanquet JP, Skimming JW.  alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells. Free Radic Res. 2004 Jul;38(7):675-82. abstract

Scumpia PO, Sarcia PJ, Kelly KM, DeMarco VG, Skimming JW.  Hypothermia induces anti-inflammatory cytokines and inhibits nitric oxide and myeloperoxidase-mediated damage in the hearts of endotoxemic rats. Chest. 2004 Apr;125(4):1483-91. abstract

Sarcia PJ, Scumpia PO, Moldawer LL, DeMarco VG, Skimming JW.  Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats. Shock. 2003 Jul;20(1):41-5. abstract

Haque IU, Huang CJ, Scumpia PO, Nasiroglu O, Skimming JW.  Intravascular infusion of acid promotes intrapulmonary inducible nitric oxide synthase activity and impairs blood oxygenation in rats. Crit Care Med. 2003 May;31(5):1454-60. abstract

Skimming JW, Nasiroglu O, Huang CJ, Wood CE, Stevens BR, Haque IU, Scumpia PO, Sarcia PJ.  Dexamethasone suppresses iNOS yet induces GTPCH and CAT-2 mRNA expression in rat lungs. Am J Physiol Lung Cell Mol Physiol. 2003 Aug;285(2):L484-91. Epub 2003 Apr 25. abstract

Scumpia PO, Sarcia PJ, DeMarco VG, Stevens BR, Skimming JW.  Hypothermia attenuates iNOS, CAT-1, CAT-2, and nitric oxide expression in lungs of endotoxemic rats. Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1231-8. Epub 2002 Aug 2. abstract