Jacqueline Sayyah

Advanced Concentration

Physiology & Pharmacology

Mentor

Peter P. Sayeski, Ph.D. 

Department

Physiology & Functional Genomics

Enrolled 

August 2004

Lab Room

M-534

Lab Phone

392-1498

E-mail

sayyahj@ufl.edu

Education

B.S., Biochemistry, University of California, Los Angeles

Dissertation Research

Pharmacological Inhibition of Jak 2 Tyrosine Kinase

Publications

1. Sayyah J and Sayeski PP.  Jak2 inhibitors: Rationale and Role as Novel Therapeutic Agents in Hematologic Malignancies.  Current Oncology Reports, In Press, 2008.

2. Sayyah J, Magis A, Ostrov DA, Allan RW, Braylan RC, and Sayeski PP.  Z3, a Novel Jak2 Tyrosine Kinase Small Molecule Inhibitor that Suppresses Jak2-mediated Pathologic Cell Growth.  Molecular Cancer Therapeutics, In Press, 2008. 

3. Godeny MD, Sayyah J, VonDerLinden D, Johns M, Ostrov DA, Caldwell-Busby J, Sayeski PP.  The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor. Cell Signal. 2007 Mar;19(3):600-9.

4. Tsurutani J, West KA, Sayyah J, Gills JJ, Dennis PA.  Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.  Cancer Res. 2005 Sep 15;65(18):8423-32

5. Laguinge L, Bajenova O, Bowden E, Sayyah J, Thomas P, Juhl H.  Surface expression and CEA binding of hnRNP M4 protein in HT29 colon cancer cells. Anticancer Res. 2005 Jan-Feb;25(1A):23-31.

6. Tsurutani J, Castillo SS, Brognard J, Granville CA, Zhang C, Gills JJ, Sayyah J, Dennis PA.  Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.  Carcinogenesis. 2005 Jul;26(7):1182-95. Epub 2005 Mar 24.

Abstracts Presented at Meetings

1.         T32 Training Grant in Hypertension, University of Florida, College of Medicine, Gainesville Florida. 

2.         Medical Guild Research Incentive Award, 2006

3.         Grinter Fellowship, 2004-2006