Kryslaine O. Lopes

Advanced Concentration

Neuroscience

Mentor

Wolfgang J. Streit, Ph.D. 

Department

Neuroscience

Enrolled 

August 2004

Lab Room

L2-162

Lab Phone

392.9596

E-mail

kolopes@ufl.edu

Education

B.S., Biological Sciences, Illinois State University

Dissertation Research

Lopes KO, Sparks DL, Streit WJ. (2008) Microglial dystrophy in the aged and alzheimer’s disease brain is associated with ferritin immunoreactivity. Glia. 2008 Apr 28. [Epub ahead of print]  abstract

Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Lopes KO, Chen Y, Iwata N, Yin KJ, Lee JM, Parent AT, Saido TC, Li YM, Sisodia SS, Thinakaran G. (2008) Evidence that CD147 modulation of Abeta levels is mediated by extracellular degradation of secreted Abeta. J Biol Chem. 2008 May 5. [Epub ahead of print]  abstract

Streit WJ, Miller KR, Lopes KO, and Njie EG. Microglial degeneration in the aging brain - Bad news for neurons. Front Biosci. 2008 May 1;13:3423-38.  abstract

Streit WJ, Miller KR, and Lopes K (2006) The central nervous system and inflammation: Microglia. In: Glia and Inflammation in Neurodegenerative Disease. Eds. Yenari MA and Giffard RG. Nova Science Publishers, New York, p. 5-23.

Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H.  Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem. 2003 Jan 31;278(5):3446-54.  abstract

Leem JY, Vijayan S, Han P, Cai D, Machura M, Lopes KO, Veselits ML, Xu H, Thinakaran G.  Presenilin 1 is required for maturation and cell surface accumulation of nicastrin. J Biol Chem. 2002 May 24;277(21):19236-40.  abstract

Bergstrom BP, Schertz KE, Weirick T, Nafziger B, Takacs SA, Lopes KO, Massa KJ, Walker QD, Garris PA.  Partial, graded losses of dopamine terminals in the rat caudate-putamen: an animal model for the study of compensatory adaptation in preclinical parkinsonism. J Neurosci Methods. 2001 Mar 30;106(1):15-28.  abstract

Lopes KO, Sparks DL, and Streit WJ (2007) Microglial degeneration increases with age and is associated with ferritin immunoreactivity. Society for Neuroscience Abstracts. San Diego, CA. 685.12

Lopes KO and Streit WJ (2007) Long-term iron storage contributes to microglial degeneration in the aged and Alzheimer’s disease brains. VIII European Meeting on Glial Cells in Health and Disease Abstracts. London, UK. A119

Lopes K and Streit WJ (2006) Ferritin-positive microglia are subject to structural deterioration. Society for Neuroscience Abstracts. Atlanta, GA. 43.2

Lopes K and Devine DP (2004) Elevation of HPA axis activity in response to repeated social defeat stress in rats. Society for Neuroscience Abstracts. San Diego, CA. 426.12

UF Medical Guild Research Incentive Award, 2007

BW Robinson Neuroscience Grant-in-Aid Achievement Award, 2007