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Barry E. Flanary |
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Barry E. Flanary |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2001 |
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Lab Room |
L2-162 |
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Lab Phone |
392-3910 |
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Education |
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B.S., Biological Sciences, Illinois State University |
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M.S., Biological Sciences, Illinois State University |
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Dissertation Research: Analysis of Rat Microglial Cellular Senescence as Determined by Measurements of Telomere Length and Telomerase Activity |
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The current focus of our work is to provide a better understanding of the roles that microglial telomere shortening and senescence plays in normal aging and in the development of AD. This is a novel area of research in AD, and no previous research has been performed in this area. We hypothesize that telomere shortening occurs in microglia over time and with normal aging. This leads to their senescence and contributes indirectly to neuronal cell death. Our short-term goals are to study telomere length and telomerase activity in rat microglia both in vitro (cells grown in a culture dish) and in vivo (cells living within an organism). Our long-term goals are to study telomere length and telomerase activity in human microglia (from non-demented and AD individuals) in vitro and to over-express telomerase in rat microglia in vitro to determine whether this prevents telomere shortening and senescence in these cells. If telomere shortening in microglia can be delayed or prevented, then this may enable these cells to delay or prevent their entry into senescence. Thus, if senescence can be avoided, microglia should be able to live longer than normal and be able to provide additional support to neurons, thereby slowing their death as well. Therefore, if telomere shortening in microglia can be delayed or prevented, then AD may also be delayed or prevented. |
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Publications |
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Flanary BE, Streit WJ. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia. 2004 Jan 1;45(1):75-88. abstract |
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Flanary BE, Streit WJ. Telomeres shorten with age in rat cerebellum and cortex in vivo. J Anti Aging Med. 2003;6(4):299-308. abstract |
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Flanary B. Review of the gerontology literature. J Anti Aging Med. 2003 Spring;6(1):41-3. abstract |
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Van Rhein SL, Flanary BE, Juliano SA. Effects of habitat type and drying on Ascogregarina barretti (Eugregarinida: Lecudinidae) infection in Aedes triseritatus (Diptera: Culicidae). J Med Entomol. 2000 Nov;37(6):950-6. abstract |
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Abstracts Presented at Meetings |
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Honors & Awards |
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last revised
2/24/05
wtm
