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Todd M. Brusko |
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Todd M. Brusko |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2002 |
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Lab Room |
R2-236 |
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Lab Phone |
392-4870 | ||
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Education |
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B.S., Microbiology & Cell Science, University of Florida |
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Dissertation Research |
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Regulatory T cells and mechanisms of immune regulation in type 1 diabetes |
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Publications |
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Araya CE, Wasserfall CH, Brusko TM, Mu W, Segal MS, Johnson RJ, Garin EH. A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol. 2006 Mar 7; [Epub ahead of print] abstract |
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Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene. 2006 Mar 15;369C:134-141. abstract |
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Brusko TM, Wasserfall CH, Agarwal A, Kapturczak MH, Atkinson MA. An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4+CD25+ Regulatory T Cells. J Immunol. 2005 May 1;174(9):5181-6. abstract |
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Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA. Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes. Diabetes. 2005 May;54(5):1407-14. abstract |
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You S, Chen C, Lee WH, Brusko T, Atkinson M, Liu CP. Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice. J Immunol. 2004 Dec 1;173(11):6777-85. abstract |
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Haller MJ, Samyn M, Nichols WW, Brusko T, Wasserfall C, Schwartz RF, Atkinson M, Shuster JJ, Pierce GL, Silverstein JH. Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes. Diabetes Care. 2004 Dec;27(12):2911-7. abstract |
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Kapturczak MH, Wasserfall C, Brusko T, Campbell-Thompson M, Ellis TM, Atkinson MA, Agarwal A. Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol. 2004 Sep;165(3):1045-53. abstract |
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Morales A, Wasserfall C, Brusko T, Carter C, Schatz D, Silverstein J, Ellis T, Atkinson M. Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care. 2004 Aug;27(8):2010-4. abstract |
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Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY. A functional variant of SUMO4, a new IkappaBalpha modifier, is associated with type 1 diabetes. Nat Genet. 2004 Aug;36(8):837-41. abstract |
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Zhang YC, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder RO, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Agarwal A, Ellis TM, Atkinson MA. Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity. Gene Ther. 2004 Feb;11(3):233-40. abstract |
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Goudy KS, Burkhardt BR, Wasserfall C, Song S, Campbell-Thompson ML, Brusko T, Powers MA, Clare-Salzler MJ, Sobel ES, Ellis TM, Flotte TR, Atkinson MA. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion. J Immunol. 2003 Sep 1;171(5):2270-8. abstract |
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Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, Wasserfall C, Goudy K, Zahr E, Poggioli R, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick H, Flotte T, Ellis TM, Ricordi C, Inverardi L, Atkinson MA. Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes. 2003 Mar;52(3):708-16. abstract |
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Goudy K, Wasserfall C, Burkhardt BA, Brusko T, Song S, Ellis T, Flotte T, Atkinson M. Evaluation of mechanism, dose, and time dependency for AAV-IL-10 gene therapy in NOD mice. Diabetes. 2002 Jun;51:1159 Suppl. 2. |
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Abstracts Presented at Meetings |
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Wasserfall C, Schwartz RF, Simon G, Binns SA, Brusko T, Stalvey M, Clare-Salzler M, Song S, Campbell-Thompson M, Flotte T, Atkinson M. A dichotomous role for interleukin-10 in the pathogenesis of type 1 diabetes. DIABETES 54: A24-A24 Suppl. 1 2005 |
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Tang M, Lu Y, Brusko T, Wasserfall C, Zhang B, Campbell-Thompson M, Atkinson MA, Song S. Prevention of type 1 diabetes by AAT gene therapy is dose and time dependent. DIABETES 54: A312-A313 Suppl. 1, 2005 |
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Haller M, Cooper S, Putnam A, Freed B, Brusko T, Chase P, Atkinson M, Schatz D. Autologous cord blood transfusion associated with prolonged honeymoon in a child with type 1 diabetes (T1D). DIABETES 54: A485-A485 Suppl. 1, 2005 |
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Stalvey M, Wasserfall C, Brusko T, Flotte T, Schatz D, Atkinson M. A pro-inflammatory state and hyperglycemia are associated with a cystic fibrosis related diabetes mouse model. DIABETES 54: A645-A645 Suppl. 1, 2005 |
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Todd M. Brusko, Clive H. Wasserfall, Michael J. Clare-Salzler, Desmond A. Schatz, Mark A. Atkinson. 65th Scientific Sessions; Meeting of the American Diabetes Association, 2005. "Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T Cells in Type 1 Diabetes", Abstract Number: 246-OR. |
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Todd M. Brusko, Clive H. Wasserfall, Schatz, Mark A. Atkinson. 65th Scientific Sessions; Meeting of the American Diabetes Association, 2005. "Dynamics of CD4+CD25+ T Cells and Soluble CD25 in Type 1 Diabetes", Abstract Number: 248-OR. |
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Honors & Awards |
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2005 Graduate Fellowship for Outstanding Research, UF College of Medicine |
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last revised 7/24/06 wtm
