GMS 6005 - Spring 2008       

Fundamentals of Developmental Biology
 
Course Director:  Paul Oh, Ph.D.
Lectures:  Mondays, Wednesdays, Fridays at 8:30-9:20 and 9:35-10:25 (LG 110A; McKnight Brain Institute)
Discussions:  Tuesdays and/or Thursdays at 8:30-9:30am (LG 110A; McKnight Brain Institute)
 Seminar:  Thursdays at 4:00-5:00 (LG101A)
Reviews & Exams

Suggested Reading:  The lecturer will provide review articles pertinent to each lecture  (check the "course documents" in the Web CT)

Shown below is a table displaying the tentative dates, titles and instructors for all of the lectures and discussions for Spring 2008.   For course content, registered students should log-in to the core course site at Web CT Vista. 
   
Day Date Room Lecture Title Faculty
L1 Mon 3/24 LG 110A

Introduction / Diverse methods & species used in developmental studies.

B. Harfe
L2 Mon 3/24 LG 110A Genetic approaches in mammalian development.  
L3 Wed 3/26 LG 110A Drosophila – AP patterning L. Zhou
L4 Wed 3/26 LG 110A Drosophila – DV patterning L. Zhou
D1 Thu 3/27 LG 110A

Journal Discussion (1):Nusslein-Volhard and Wieschaus (1980) Mutations affecting segment number and polarity in Drosophila. Nature 287, 795.

 L. Zhou
S Thu 3/27 LG101A IDP Seminar  
L3 Fri 3/28  LG 110A Midblastula transition (switch from maternal to fetal control) J. Resnick
L4 Fri 3/28 LG 110A Gastrulation / (Mesoderm Induction & Organizer) J. Resnick
L5 Mon 3/31 LG 110A

Germ cell differentiation

 J. Resnick
L6 Mon 3/31 LG 110A Urogenital Development/Sex differentiation J. Resnick
D2 Tue 4/1 LG 110A

Journal Discussion (2):

Belaoussoff, M., Farrington, S.M., and Baron, M.H. 1998.

Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling and the mouse embryo. Development 125:5009-5018.

 J. Resnick
L7 Wed 4/2 LG 110A Left-Right Asymmetry S. Paul Oh
L8 Wed 4/2 LG 110A Neural Induction S. Paul Oh
D3 Thu 4/3 LG 110A

Journal Discussion (3)

McGrath, J., et al., 2003 Two Populations of Node Monocilia

Initiate Left-Right Asymmetry in Mouse. Cell, 114, 61-73.

 S. Paul Oh
S Thu 4/3 LG101A IDP Seminar
L9 Fri 4/4  LG 110A Cardiac Development (I) H.Kasahara
L10 Fri 4/4 LG 110A Cardiac Development (II) H. Kasahara
L11 Mon 4/7 LG 110AA Limb patterning (I) B. Harfe
L12 Mon 4/7 LG 110A Limb patterning (II) B. Harfe
  Tue 4/8 LG 110A

Exam 1

  
  Wed 4/9 LG 110A Zdbrzfish as a model system for studying Neural Development K. Epley
D5 Thu 4/10 LG 110A Journal Discussion (5)  
S Thu 4/10 LG101A IDP Seminar
 
L13 Fri 4/11 LG 110A Muscle Development (I) M.Swanson
L14 Fri 4/11 LG 110A Muscle  Development (II) M.Swanson
 
L17 Mon 4/14 LG 110A Somitogenesis  and Vertebral Patterning: Vascular Develepment S. Paul Oh
L18 Mon 4/14 LG 110A Vascular Development S. Paul Oh
D6 Tue 4/15 LG 110A

Journal Discussion (6)

Zhong, T.P., Childs, S., Leu, J.P., and Fishman, M.C. 2001  Gridlock signalling pathway fashions the first embryonic artery.  Nature 414:216-220.

 S. Paul Oh
L19 Wed 4/16 LG 110A External Genitalia Development M. Cohn
L20 Wed 4/16 LG 110A Evolution of developmental mechanisms M. Cohn
D7 Thu 4/17 LG 110A

Journal Discussion (7)

Tarchini, B.  et al., 2006. Control of Hoxd Genes' Collinearity during Early Limb Development Dev. Cell 10, 93-103.

 M. Cohn
S Thu 4/17 LG 110A IDP Seminar
L21 Fri 4/18 LG 110AA Stem Cells in Development and Homeostasis Regeration and Regenerative Medicine N. Terada
L23 Mon 4/21 LG 110AA Hematopoiesis and Leukemia L. Wu
D8 Tue 4/22 LG 110A

Journal Discussion (8)

Calvi, L.M. et al., 2003. Osteoblastic cells regulate the haematopoietic stem cell niche.  Nature 425. 841-846

L. Wu
Wed 4/23 LG 110A Exam (8:30-10:30)  
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