L. Shannon Holliday, Ph.D.
Associate Professor
Orthodontics
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L. Shannon Holliday, Ph.D. |
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Osteoclast activation in bone disease Osteoclasts are highly specialized cells that are adapted to resorb mineralized bone. A major part of that adaptation involves increasing the expression of vacuolar H+-ATPase (V-ATPase) a multisubunit enzyme that serves the essential housekeeping function of acidifying compartments of the endocytic pathway. In osteoclasts, V-ATPase is targeted to the plasma membrane and this is required for bone resorption. We have three projects in the lab. First, we are seeking to understand the mechanism by which osteoclasts target V-ATPase to the plasma membrane. Second, we are examining the development of agents (RNAi, or small molecules) that block this targeting mechanism, with the goal of developing new treatments for osteoclast mediated disease. Third, we are examining the role of microRNAs in regulating the unique gene expression required for osteoclast formation and activity.
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Status: May Be Accepting New Students This Year Contact Information: office: D7-18 lab: D7-16 phone: 352-273-5689 email: sholliday@dental.ufl.edu Biography: Dr. Holliday was born in Boomer, West Virginia, earned a BS in Biology/Business Emphasis from West Virginia Tech, and a Ph.D. in Cell Biology studying the amoeboid movement of nematode sperm with Dr. Thomas M. Roberts at the Florida State University. He did a post doc at the NIH with Dr. Edward D. Korn studying actin biochemistry, and a second post doc with Dr. Stephen L. Gluck at Washington University in St Louis where he became interested in osteoclasts and the vacuolar H+-ATPase. Dr. Holliday came to the University of Florida in 1999 as a Research Assistant Professor in the Division of Nephrology, and joined the Department of Orthodontics in 2001 as an Assistant Professor. He was promoted to Associate Professor in 2006. Dr. Holliday wife Natalia is a native of Russia and works as the Accounting Manager at SynQuest Laboratories in Alachua. They have a daughter Sophia who was born in 1999. |
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