Michael R. Bubb, M.D.
Associate Professor
Medicine
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Michael R. Bubb, M.D. |
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Cell biology and biochemistry of actin-binding proteins involved in apoptosis, angiogenesis, neural plasticity and cancer biology Dr. Bubb's laboratory studies the regulation of actin polymerization in cell motility. We investigate the cell biology and biochemistry of actin-binding proteins specifically as they pertain to such topics as apoptosis, angiogenesis, immunology and cancer biology. We also study pharmacologic agents that affect actin polymerization. We use a variety of biophysical techniques to answer specific questions regarding mechanisms controlling cell motility, including time-dependent fluorescence spectroscopy and analytical ultracentrifugation. Specific ongoing projects include (1) a study of the MARCKS protein as it relates to neurodevelopment, synaptic plasticity & memory, (2) a study of the structure & immunomodulatory properties of thymosin 4, and (3) the development of cancer chemotherapeutic agents that target the actin cytoskeleton, and (4) a study of predicted outcomes and response to therapy in rheumatoid arthritis based on the role of TNF-alpha in cytoskeletal dynamics.
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Status: Inquire About New Students This Year Contact Information: office: Malcom Randall VAMC E376 lab: Malcom Randall VAMC E314-E315 phone: 352-273-5346 email: bubbmr@medicine.ufl.edu Home Page Biography: Fellowship: NIH Bethesda MD Residency: Barnes Hospital, Washington Univ., St. Louis, MO MD: Johns Hopkins (1985) BS Engineering Physics: South Dakota State University (1981) |
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