Hideko Kasahara, M.D., Ph.D.
Associate Professor
Physiology and Functional Genomics
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Hideko Kasahara, M.D., Ph.D. |
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Molecular Cardiology Our current research interest is to understand the function of Nkx2.5; an evolutionarily conserved NK2 class of homeobox transcription factor in mature cardiomyocytes. Within the genomic analysis of cardiovascular diseases, mutations of NKX2.5 (capitals are used for human Nkx2.5) have emerged as a fascinating story both because of the roles this transcription factor plays in formation of the developing heart, as well as in maintenance of the normal heart after birth and through to adulthood. We are particularly interested in a cardiac disorder in adults: progressive AV block and left ventricular dysfunction caused by NKX2.5 mutations. However, the current understanding of the NKX2.5 function is very limited in explaining the molecular mechanisms explaining why the molecular mechanisms of mutations of NKX2.5 cause congenital heart disease. |
Status: Inquire About Students This Year Contact Information: office: Medical Sciences, M540 lab: Medical Sciences, M538, M540, M541 phone: (352) 846-1503 email: hkasahar@phys.med.ufl.edu Home Page Biography: Education: 1985: M.D. Nagoya University Medical School, Japan (Medicine) 1994: Ph.D. Nagoya University Medical School, Japan (Cardiology, Cell Biology) 1991-1994: National Institute for Physiological Sciences, Japan (Cell Biology) Postdoctoral Training: 1994-1997: Postdoctoral Fellow, University of Michigan, Ann Arbor, MI 1997-1998: Postdoctoral Fellow, Beth Israel Deaconess Medical Center / Harvard Medical School, Boston, MA Academic Appointments: 1998-2001: Instructor of Medicine, Harvard Medical School / Beth Israel Deaconess Medical Center 2002- Assistant Professor in the Department of Physiology and Functional Genomics, University of Florida College of Medicine |
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