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Physiology & Pharmacology Alumni |
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Physiology & Pharmacology Alumni |
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Physiology & Pharmacology |
Christopher J. Bowman, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1996 - May 2002 |
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Dissertation Title |
Gene regulation in teleosts by estradiol and estrogen mimics |
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Professional Positions |
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CIIT Centers for Health Research, Research Triangle Park, NC |
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Education |
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B.S., University of Florida |
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Publications |
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Bowman CJ, Barlow NJ, Turner KJ, Wallace DG, Foster PM. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003 Aug;74(2):393-406. abstract |
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Turner KJ, McIntyre BS, Phillips SL, Barlow NJ, Bowman CJ, Foster PM. Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicol Sci. 2003 Jul;74(1):114-28. abstract |
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Bowman CJ, Kroll KJ, Gross TG, Denslow ND. Estradiol-induced gene expression in largemouth bass (Micropterus salmoides). Mol Cell Endocrinol. 2002 Oct 31;196(1-2):67-77. abstract |
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Hemmer MJ, Bowman CJ, Hemmer BL, Friedman SD, Marcovich D, Kroll KJ, Denslow ND. Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol. Aquat Toxicol. 2002 Jul;58(1-2):99-112. abstract |
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Denslow ND, Lee HS, Bowman CJ, Hemmer MJ, Folmar LC. Multiple responses in gene expression in fish treated with estrogen. Comp Biochem Physiol B Biochem Mol Biol. 2001 Jun;129(2-3):277-82. abstract |
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Hemmer MJ, Hemmer BL, Bowman CJ, Kroll KJ, Folmar LC, Marcovich D, Hoglund MD, Denslow ND. Effects of p-nonylphenol, methoxychlor, and endosulfan on vitellogenin induction and expression in sheepshead minnow (Cyprinodon variegatus). Environ Toxicol Chem. 2001 Feb;20(2):336-43. abstract |
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Denslow ND, Bowman CJ, Ferguson RJ, Lee HS, Hemmer MJ, Folmar LC. Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation. Gen Comp Endocrinol. 2001 Mar;121(3):250-60. abstract |
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Bowman CJ, Kroll KJ, Hemmer MJ, Folmar LC, Denslow ND. Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus). Gen Comp Endocrinol. 2000 Dec;120(3):300-13. abstract |
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Funkenstein B, Bowman CJ, Denslow ND, Cardinali M, Carnevali O. Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish, Sparus aurata. Mol Cell Endocrinol. 2000 Sep 25;167(1-2):33-41. abstract |
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Folmar LC, Hemmer M, Hemmer R, Bowman C, Kroll K, Denslow ND. Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay. Aquat Toxicol. 2000 May 1;49(1-2):77-88. abstract |
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Honors & Awards |
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Graduate Fellowship for Outstanding Reseach, UF College of Medicine, 2000 |
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Jonathan D. Bui, M.D., Ph.D. |
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Advanced Concentration |
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Mentor |
M. Ian Phillips, Ph.D. & Stephen J. Blackband, Ph.D. |
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Department |
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Enrolled |
August 1996 - August 2000 (Ph.D.) |
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Dissertation Title |
Quantitative NMR studies of perfused brain slices |
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COS Profile |
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Professional Positions |
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Clinical Fellow, Harvard University, Beth Israel, Medicine |
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Education |
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B.S., Zoology, B.S., Biophysical Chemistry and Molecular Biology, University of Florida |
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Publications |
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Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation. 2000 Feb 15;101(6):682-8. abstract |
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Forder JR, Bui JD, Buckley DL, Blackband SJ. MR imaging measurement of compartmental water diffusion in perfused heart slices. Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1280-5. abstract |
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Hsu EW, Buckley DL, Bui JD, Blackband SJ, Forder JR. Two-component diffusion tensor MRI of isolated perfused hearts. Magn Reson Med. 2001 Jun;45(6):1039-45. abstract |
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Shi J, Bui JD, Yang SH, He Z, Lucas TH, Buckley DL, Blackband SJ, King MA, Day AL, Simpkins JW. Estrogens decrease reperfusion-associated cortical ischemic damage: an MRI analysis in a transient focal ischemia model. Stroke. 2001 Apr;32(4):987-92. abstract |
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Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation. 2000 Feb 15;101(6):682-8. abstract |
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Blackband SJ, Buckley DL, Bui JD, Phillips MI. NMR microscopy--beginnings and new directions. MAGMA. 1999 Dec;9(3):112-6. Review. abstract |
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Bui JD, Zelles T, Lou HJ, Gallion VL, Phillips MI, Tan W. Probing intracellular dynamics in living cells with near-field optics. J Neurosci Methods. 1999 Jul 1;89(1):9-15. abstract |
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Buckley DL, Bui JD, Phillips MI, Blackband SJ. MRI measurement of cell volume fraction in the perfused rat hippocampal slice. Magn Reson Med. 1999 Sep;42(3):603-7. abstract |
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Bui JD, Buckley DL, Phillips MI, Blackband SJ. Nuclear magnetic resonance imaging measurements of water diffusion in the perfused hippocampal slice during N-methyl-D-aspartate-induced excitotoxicity. Neuroscience. 1999;93(2):487-90. abstract |
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Bui JD, Nammari DR, Buckley DL, Inglis BA, Silver XS, Mareci TH, Phillips MI. In vivo dynamics and distribution of intracerebroventricularly administered gadodiamide, visualized by magnetic resonance imaging. Neuroscience. 1999 Mar;90(3):1115-22. abstract |
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Buckley DL, Bui JD, Phillips MI, Zelles T, Inglis BA, Plant HD, Blackband SJ. The effect of ouabain on water diffusion in the rat hippocampal slice measured by high resolution NMR imaging. Magn Reson Med. 1999 Jan;41(1):137-42. abstract |
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Blackband SJ, Bui JD, Buckley DL, Zelles T, Plant HD, Inglis BA, Phillips MI. MR microscopy of perfused brain slices. Magn Reson Med. 1997 Dec;38(6):1012-5. abstract |
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Bui JD, Kimura B, Phillips MI. Losartan potassium, a nonpeptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood-brain barrier. Eur J Pharmacol. 1992 Aug 14;219(1):147-51. abstract |
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Xuefang Cao, Ph.D. |
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Advanced Concentration |
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Mentor |
William Stratford May, Jr., M.D., Ph.D. |
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Department |
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Enrolled |
August 1999 - December 2003 |
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Dissertation Title |
Cleavage of Bas to Pis Bax facilitates stress-induced apoptosis |
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Professional Positions |
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Education |
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Publications |
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Cao X, Deng X, May WS. Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax. Blood. 2003 Oct 1;102(7):2605-14. abstract |
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Shuzhen Chen, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
TGF-beta-1 regulation of chemokine receptors in rat microglia and human macrophages (full text) |
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Professional Positions |
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Postdoctoral Associate, Harvard Medical School |
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Education |
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B.S., College Of Life Sciences, Beijing University |
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Publications |
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Davis CN, Chen S, Boehme SA, Bacon KB, Harrison JK. Chemokine receptor binding and signal transduction in native cells of the central nervous system. Methods. 2003 Apr;29(4):326-34. abstract |
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Chen S, Luo D, Streit WJ, Harrison JK. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. J Neuroimmunol. 2002 Dec;133(1-2):46-55. abstract |
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Harrison JK, Fong AM, Swain PA, Chen S, Yu YR, Salafranca MN, Greenleaf WB, Imai T, Patel DD. Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. J Biol Chem. 2001 Jun 15;276(24):21632-41. abstract |
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Honors & Awards |
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Best Thesis of the Department of Cell Biology and Genetics, Beijing University, 1999 |
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Gangsong Scholarshop, Beijing University, 1998 |
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Xiyue Scholarship, Beijing University, 1997 |
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Tan Jiazhen (C.C. Tan) Life Science Scholarship |
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Christopher N. Davis, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - August 2004 |
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Dissertation Title |
Mammalian and viral chemokines provide insight into the mechanism of chemokine receptor activation (full text) |
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Professional Positions |
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Postdoctoral Associate, Dept. of Neuropharmacology, The Scripps Research Institute, San Diego, CA |
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Education |
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B.S., Neurobiological Sciences and Psychology, University of Florida |
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Publications |
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Streit WJ, Davis CN, Harrison JK. Role of fractalkine (CX3CL1) in regulating neuron-microglia interactions: development of viral-based CX3CR1 antagonists. Curr Alzheimer Res. 2005 Apr;2(2):187-9. abstract |
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Davis CN, Zujovic V, Harrison JK. vMIP-II and fractalkine (CX3CL1) chimeras identify molecular determinants of affinity, efficacy, and selectivity at CX3CR1. Mol Pharmacol. 2004 Dec;66(6):1431-9. abstract |
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Davis CN, Chen S, Boehme SA, Bacon KB, Harrison JK. Chemokine receptor binding and signal transduction in native cells of the central nervous system. Methods. 2003 Apr;29(4):326-34. abstract |
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Ileana Montanez-Clemente Elder, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - August 2004 |
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Dissertation Title |
Kinetic and structural studies on the activation of the proton transfer in catalysis by carbonic anhydrase |
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Professional Positions |
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Education |
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B.S., Industrial Chemistry, University of Puerto Rico |
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Publications |
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Elder I, Han S, Tu C, Steele H, Laipis PJ, Viola RE, Silverman DN. Activation of carbonic anhydrase II by active-site incorporation of histidine analogs. Arch Biochem Biophys. 2004 Jan 15;421(2):283-9. abstract |
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An H, Tu C, Duda D, Montanez-Clemente I, Math K, Laipis PJ, McKenna R, Silverman DN. Chemical rescue in catalysis by human carbonic anhydrases II and III. Biochemistry. 2002 Mar 5;41(9):3235-42. abstract |
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Montanez-Clemente I, Alvira E, Macias M, Ferrer A, Fonceca M, Rodriguez J, Gonzalez A, Barletta G. Enzyme activation in organic solvents: co-lyophilization of subtilisin Carlsberg with methyl-beta-cyclodextrin renders an enzyme catalyst more active than the cross-linked enzyme crystals. Biotechnol Bioeng. 2002 Apr 5;78(1):53-9. abstract |
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Martinez SG, Alvira E, Cordero LV, Ferrer A, Montanes-Clemente I, Barletta G. High initial activity but low storage stability observed for several preparations of subtilisin Carslberg suspended in organic solvents. Biotechnol Prog. 2002 Nov-Dec;18(6):1462-6. abstract |
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Santos AM, Montañez Clemente I, Barletta G, Griebenow K. Activation of serine protease subtilisin Carlsberg in organic solvents: combined effect of methyl-ß-cyclodextrin and water. Biotech Letters. 1999 Dec;21(12):1113-8. |
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Griebenow K, Laureano YD, Santos AM, Clemente IM, Rodriguez L, Vidal MW, Barletta G. Improved enzyme activity and enantioselectivity in organic solvents by methyl--cyclodextrin. J Am Chem Soc. 1999;121(36); 8157-8163. |
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Jenafer Evans, Ph.D. |
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Advanced Concentration |
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Mentor |
C. H. Gelband, Ph.D. |
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Department |
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Enrolled |
August 1996 - May 2001 |
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Dissertation Title |
Angiotensin II modulation of neuronal calcium current (full text) |
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Professional Positions |
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Postdoctoral Associate, Calcium Signals Laboratory (David Yue, M.D., Ph.D.), Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD |
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Education |
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B.S., Chemistry, University of Virginia |
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Publications |
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Evans J, Sumners C, Moore J, Huentelman MJ, Deng J, Gelband CH, Shaw G. Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol. 2002 Feb;87(2):1076-85. abstract |
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Evans J, Gelband CH. A novel Ca2+ channel in vascular smooth muscle? Circ Res. 1999 Oct 1;85(7):651-2. Review. abstract |
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Honors & Awards |
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Outstanding Chemistry Student Award, University of Virginia, 1996 |
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Melissa A. Fleegal, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1997 - August 2002 |
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Dissertation Title |
Angiotensin II modulation of neuronal intracellular signaling cascades regulates short-term and long-term physiological responses (full text) |
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Professional Positions |
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Education |
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B.S., Biology, Lebanon Valley College, PA |
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Publications |
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Fleegal MA, Sumners C. Angiotensin II induction of AP-1 in neurons requires stimulation of PI3-K and JNK. Biochem Biophys Res Commun. 2003 Oct 17;310(2):470-7. abstract |
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Fleegal MA, Sumners C. Drinking behavior elicited by central injection of angiotensin II: roles for protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R632-40. abstract |
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Marcus JS, Karackattu SL, Fleegal MA, Sumners C. Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB. Glia. 2003 Jan 15;41(2):152-60. abstract |
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Sumners C, Fleegal MA, Zhu M. Angiotensin AT1 receptor signalling pathways in neurons. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):483-90. Review. abstract |
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Busche S, Gallinat S, Fleegal MA, Raizada MK, Sumners C. Novel role of macrophage migration inhibitory factor in angiotensin II regulation of neuromodulation in rat brain. Endocrinology. 2001 Nov;142(11):4623-30. abstract |
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Baghdoyan HA, Lydic R, Fleegal MA. M2 muscarinic autoreceptors modulate acetylcholine release in the medial pontine reticular formation. J Pharmacol Exp Ther. 1998 Sep;286(3):1446-52. abstract |
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Roth MT, Fleegal MA, Lydic R, Baghdoyan HA. Pontine acetylcholine release is regulated by muscarinic autoreceptors. Neuroreport. 1996 Nov 25;7(18):3069-72. abstract |
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Honors & Awards |
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Graduate Fellowship for Outstanding Reseach, UF College of Medicine, 2000 |
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Monica L. Gardon, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
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August 1996 - December 2003 |
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Dissertation Title |
Functional remodeling of the renal and cerebral resistance vasculature in hypertensive rats |
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Professional Positions |
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Education |
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Publications |
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Gardon M, Raizada MK, Katovich MJ, Berecek KH, Gelband CH. Gene therapy for hypertension and restenosis. J Renin Angiotensin Aldosterone Syst. 2000 Sep;1(3):211-6. Review. |
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Gardon ML, Gelband CH, Katovich MJ, Raizada MK. The potential use of gene therapy in the control of hypertension. Drugs Today (Barc). 1999 Dec;35(12):925-30. abstract |
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Damian Giroux, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - May 2002 |
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Dissertation Title |
Estrogen influences on fetal CNS cyclooxygenase and nitric oxide synthase isoforms in response to cerebral hypoperfusion |
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Professional Positions |
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Education |
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M.S., University of Florida |
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Publications |
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Wood CE, Giroux D, Gridley K. Fetal brain regional responses to cerebral hypoperfusion: modulation by estrogen. Brain Res. 2003 Dec 12;993(1-2):84-9. abstract |
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Wood CE, Giroux D. Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheep. J Physiol. 2003 Jun 1;549(Pt 2):573-81. abstract |
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Deauseault D, Giroux D, Wood CE. Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus and brainstem. Neuroendocrinology. 2000 May;71(5):287-91. abstract |
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William B. Greenleaf, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
Proton transfer in catalysis by iron and manganese superoxide dismutase |
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Professional Positions |
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Postdoctaral Associate, University of Colorado Health Science Center |
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Education |
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Publications |
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Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Role of hydrogen bonding in the active site of human manganese superoxide dismutase. Biochemistry. 2004 Jun 8;43(22):7038-45. abstract |
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Hearn AS, Fan L, Lepock JR, Luba JP, Greenleaf WB, Cabelli DE, Tainer JA, Nick HS, Silverman DN. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase. J Biol Chem. 2004 Feb 13;279(7):5861-6. abstract |
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Greenleaf WB, Silverman DN. Activation of the proton transfer pathway in catalysis by iron superoxide dismutase. J Biol Chem. 2002 Dec 20;277(51):49282-6. abstract |
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Honors and Awards |
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Alumni Graduate Fellowship, University of Florida |
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Mercz Index Award, Florida State University |
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Phi Beta Kappa, Alpha of Florida Chapter, Florida State University |
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Golden Key National Honor Society, Florida State University |
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National Merit Scholarship, National Merit Corporation, Florida State University |
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National Merit Scholarship, Florida State University |
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Renita Handayani, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - December 2004 |
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Dissertation Title |
Prospective cancer chemoprevention agents: Mechanisms of the effects of soy isoflavone and vitamin E on the regulation of p21 (WAF1/CIP1) gene expression |
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Professional Positions |
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Education |
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B.S., Pharmacy |
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Publications |
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Ason B, Handayani R, Williams CR, Bertram JG, Hingorani MM, O'Donnell M, Goodman MF, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. J Biol Chem. 2003 Mar 21;278(12):10033-40. abstract |
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Amy S. Hearn, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1996 - May 2001 |
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Dissertation Title |
Product inhibition in human manganese superoxide dismutase |
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Professional Positions |
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Postdoctoral Associate, American Lung Association Fellow, Dept. Neuroscience, UF College of Medicine |
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Education |
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B.S., University of Florida |
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Publications |
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Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Role of hydrogen bonding in the active site of human manganese superoxide dismutase. Biochemistry. 2004 Jun 8;43(22):7038-45. abstract |
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Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition. J Biol Chem. 2004 Mar 26;279(13):12769-76. abstract |
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Hearn AS, Fan L, Lepock JR, Luba JP, Greenleaf WB, Cabelli DE, Tainer JA, Nick HS, Silverman DN. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase. J Biol Chem. 2004 Feb 13;279(7):5861-6. abstract |
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Hearn AS, Stroupe ME, Cabelli DE, Ramilo CA, Luba JP, Tainer JA, Nick HS, Silverman DN. Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel. Biochemistry. 2003 Mar 18;42(10):2781-9. abstract |
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Hearn AS, Stroupe ME, Cabelli DE, Lepock JR, Tainer JA, Nick HS, Silverman DN. Kinetic analysis of product inhibition in human manganese superoxide dismutase. Biochemistry. 2001 Oct 9;40(40):12051-8. abstract |
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Cabelli DE, Guan Y, Leveque V, Hearn AS, Tainer JA, Nick HS, Silverman DN. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase. Biochemistry. 1999 Sep 7;38(36):11686-92. abstract |
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Hearn AS, Tu C, Nick HS, Silverman DN. Characterization of the product-inhibited complex in catalysis by human manganese superoxide dismutase. J Biol Chem. 1999 Aug 27;274(35):24457-60. abstract |
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Yi Hua, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - December 2002 |
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Dissertation Title |
Progesterone and corticosteroid interaction during pregnancy in ewes |
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Professional Positions |
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Education |
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Publications |
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Richards EM, Hua Y, Keller-Wood M. Pharmacology and physiology of ovine corticosteroid receptors. Neuroendocrinology. 2003 Jan;77(1):2-14. abstract |
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Matthew J. Huentelman, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - December 2003 |
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Dissertation Title |
HIV-1 based viral vector development for gene transfer to the cardiovascular system (full text) |
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Professional Positions |
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Education |
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B.S., Ohio State University, Columbus, OH |
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Publications |
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Huentelman MJ, Zubcevic J, Hernandez Prada JA, Xiao X, Dimitrov DS, Raizada MK, Ostrov DA. Structure-Based Discovery of a Novel Angiotensin-Converting Enzyme 2 Inhibitor. Hypertension. 2004 Oct 18;44:1-4. abstract |
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Metcalfe BL, Huentelman MJ, Parilak LD, Taylor DG, Katovich MJ, Knot HJ, Sumners C, Raizada MK. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension. 2004 Jun;43(6):1233-8. abstract |
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Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK. Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics. 2003 Feb 6;12(3):221-8. abstract |
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Huentelman MJ, Reaves PY, Katovich MJ, Raizada MK. Large-scale production of retroviral vectors for systemic gene delivery. Methods Enzymol. 2002;346:562-73. |
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Metcalfe BL, Sellers KW, Jeng MJ, Huentelman MJ, Katovich MJ, Raizada MK. Gene therapy for cardiovascular disorders: is there a future? Ann N Y Acad Sci. 2001 Dec;953:31-42. Review. abstract |
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Pachori AS, Huentelman MJ, Francis SC, Gelband CH, Katovich MJ, Raizada MK. The future of hypertension therapy: sense, antisense, or nonsense? Hypertension. 2001 Feb;37(2 Part 2):357-64. Review. abstract |
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Susan E. LeFrancois, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - December 2004 |
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Dissertation Title |
A Structure Activity Investigation of Benzylidene Anabaseine Interactions with the Alpha7 Nicotinic Acetylcholine Receptor |
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Professional Positions |
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Education |
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|
B.S., University of South Florida |
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Publications |
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Kem WR, Wildeboer K, LeFrancois S, Raja M, Marszalec W, Braekman JC. Nicotinic receptor inhibition by Tetraponera ant alkaloids. Cell Mol Neurobiol. 2004 Aug;24(4):535-51. abstract |
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Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol Pharmacol. 2004 Jan;65(1):56-67. abstract |
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Gang Li, Ph.D. |
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Advanced Concentration |
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Mentor |
||
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Department |
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Enrolled |
August 1999 - August 2003 |
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Dissertation Title |
Effects of the melanocortin agonist melanotan II, central pro-opiomelanocortin and interleukin-6 gene therapies on the regulation of body weight and energy homeostasis (full text) |
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Professional Positions |
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Education |
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B.Med., Zhejiang University School of Medicine, P.R. China |
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M.D., Peking Union Medical College, P.R. China |
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Publications |
||
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Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol. 2004 Jul;182(1):123-32. abstract |
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Li G, Mobbs CV, Scarpace PJ. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes. 2003 Aug;52(8):1951-7. abstract |
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Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ. Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience. 2002;115(3):879-89. abstract |
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Lingyun Li, Ph.D. |
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Advanced Concentration |
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Mentor |
||
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Department |
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Enrolled |
August 1996 - December 2000 |
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Dissertation Title |
Studies of the anticancer effects of the vascular targeting agent combretastatin A-4 disodium phosphate (CA4DP) |
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Professional Positions |
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Education |
||
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Publications |
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Rojiani AM, Li L, Rise L, Siemann DW. Activity of the vascular targeting agent combretastatin A-4 disodium phosphate in a xenograft model of AIDS-associated Kaposi's sarcoma. Acta Oncol. 2002;41(1):98-105. abstract |
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Li L, Rojiani AM, Siemann DW. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncol. 2002;41(1):91-7. abstract |
||
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Li L, Rojiani A, Siemann DW. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):899-903. abstract |
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Michelle A. McGarry, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1997 - August 2001 |
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Dissertation Title |
Benzo(A) pyrene-mediated effects on cellular adhesion and signal transduction pathways in endometrial cancer |
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Professional Positions |
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| Resident, Dept. of Pediatrics, University of Chicago | ||
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Medical Student, University of Florida College of Medicine |
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Education |
||
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Publications |
||
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McGarry MA, Charles GD, Medrano T, Bubb MR, Grant MB, Campbell-Thompson M, Shiverick KT. Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell adhesion proteins in human uterine RL95-2 cells. Biochem Biophys Res Commun. 2002 May 31;294(1):101-7. abstract |
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Beverly L. Metcalfe, Ph.D. |
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Advanced Concentration |
||
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
Defining the role of the angiotensin II type 2 receptor in cardiovascular disease |
|
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Professional Positions |
||
|
Postdoctoral Associate, University of Florida College of Medicine, Dept. of Physiology & Functional Genomics |
||
|
Education |
||
|
Publications |
||
|
Metcalfe BL, Huentelman MJ, Parilak LD, Taylor DG, Katovich MJ, Knot HJ, Sumners C, Raizada MK. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension. 2004 Jun;43(6):1233-8. abstract |
||
|
Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK. Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics. 2003 Feb 6;12(3):221-8. Epub 2002 Dec 10. abstract |
||
|
Metcalfe BL, Sellers KW, Jeng MJ, Huentelman MJ, Katovich MJ, Raizada MK. Gene therapy for cardiovascular disorders: is there a future? Ann N Y Acad Sci. 2001 Dec;953:31-42. Review. abstract |
||
|
Metcalfe BL, Raizada M, Katovich MJ. Genetic targeting of the renin-angiotensin system for long-term control of hypertension. Curr Hypertens Rep. 2002 Feb;4(1):25-31. Review. abstract |
||
Hao Pan, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
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Enrolled |
August 2001 - May 2006 |
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|
Dissertation Title |
||
|
Professional Positions |
||
|
Education |
||
|
B.S., Biochemistry, Nanjing University (P.R. China) |
||
|
Publications |
||
|
Grant MB, Afzal A, Spoerri P, Pan H, Shaw LC, Mames RN. The role of growth factors in the pathogenesis of diabetic retinopathy. Expert Opin Investig Drugs. 2004 Oct;13(10):1275-93. abstract |
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|
Pan H, Nguyen NQ, Yoshida H, Bentzien F, Shaw LC, Rentier-Delrue F, Martial JA, Weiner R, Struman I, Grant MB. Molecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2413-9. abstract |
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|
||
|
Abstracts Presented at Meetings Through Graduate Studies |
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Honors & Awards |
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|
|
||
Andon Plazcek, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 2000 - April 2005 |
|
|
Dissertation Title |
Regulation of a7 Nicotinic Acetylcholine Receptor Function and Pharmacology by Amino Acid Sequence in the Second Transmembrane Domain |
|
|
Education |
||
|
B.S., University of South Florida |
||
| Professional Position Postdoctoral Associate, UF Department of Pharmacology & Therapeutics | ||
|
Publications |
||
|
Placzek AN, Grassi F, Papke T, Meyer EM, Papke RL. A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors. Mol Pharmacol. 2004 Jul;66(1):169-77. abstract |
||
|
Tan J, Town T, Abdullah L, Wu Y, Placzek A, Small B, Kroeger J, Crawford F, Richards D, Mullan M. CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker of Alzheimer's disease. J Neuroimmunol. 2002 Nov;132(1-2):164-72. abstract |
||
|
Papke RL, Horenstein BA, Placzek AN. Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics. Mol Pharmacol. 2001 Dec;60(6):1365-74. abstract |
||
|
Suo Z, Su G, Placzek A, Kundtz A, Humphrey J, Crawford F, Mullan M. A beta vasoactivity in vivo. Ann N Y Acad Sci. 2000 Apr;903:156-63. abstract |
||
|
Tan J, Town T, Placzek A, Kundtz A, Yu H, Mullan M. Bcl-X(L) inhibits apoptosis and necrosis produced by Alzheimer's beta-amyloid1-40 peptide in PC12 cells. Neurosci Lett. 1999 Sep 3;272(1):5-8. abstract |
||
|
Tan J, Town T, Paris D, Placzek A, Parker T, Crawford F, Yu H, Humphrey J, Mullan M. Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosis. J Neuroimmunol. 1999 Jun 1;97(1-2):77-85. abstract |
||
|
Suo Z, Humphrey J, Kundtz A, Sethi F, Placzek A, Crawford F, Mullan M. Soluble Alzheimers beta-amyloid constricts the cerebral vasculature in vivo. Neurosci Lett. 1998 Nov 27;257(2):77-80. abstract |
||
|
Suo Z, Tan J, Placzek A, Crawford F, Fang C, Mullan M. Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: the roles of cytokines and CD40. Brain Res. 1998 Oct 5;807(1-2):110-7. abstract |
||
|
Abstracts Presented at Meetings |
||
|
Meeting Society for Neuroscience 29th Annual Meeting, "CD45 isoform alterations in CD4+ T cells as a potential diagnostic marker of Alzheimers Disease", Miami Beach, FL |
||
Sharon K. Reimsnider, Ph.D. |
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|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 1997 - December 2003 |
|
|
Dissertation Title |
Does cyclooxygenase modulate the fetal hypothalamic-pituitary-adrenal axis? |
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|
Professional Positions |
||
|
Education |
||
|
Publications |
||
|
Reimsnider SK, Wood CE. Co-localisation of prostaglandin endoperoxide synthase and immunoreactive adrenocorticotrophic hormone in ovine foetal pituitary. J Endocrinol. 2004 Feb;180(2):303-10. abstract |
||
|
Reimsnider SK, Eckenrode SE, Marron MP, Muir A, She JX. IL4 and IL4Ralpha genes are not linked or associated with type 1 diabetes. Pediatr Res. 2000 Feb;47(2):246-9. abstract |
||
Tara Sabo-Attwood, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 1998 - August 2003 |
|
|
Dissertation Title |
Characterization of estrogen receptors and estrogen receptor-regulated genes in largemouth bass |
|
|
Professional Positions |
||
|
Education |
||
|
Publications |
||
|
Sabo-Attwood T, Kroll KJ, Denslow ND. Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol. Mol Cell Endocrinol. 2004 Apr 15;218(1-2):107-18. abstract |
||
|
Larkin P, Sabo-Attwood T, Kelso J, Denslow ND. Analysis of gene expression profiles in largemouth bass exposed to 17-beta-estradiol and to anthropogenic contaminants that behave as estrogens. Ecotoxicology. 2003 Dec;12(6):463-8. abstract |
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|
Larkin P, Sabo-Attwood T, Kelso J, Denslow ND. Gene expression analysis of largemouth bass exposed to estradiol, nonylphenol, and p,p'-DDE. Comp Biochem Physiol B Biochem Mol Biol. 2002 Dec;133(4):543-57. abstract |
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Von G. Samedi, Ph.D. |
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|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 1997 - August 2001 |
|
|
Dissertation Title |
Antiproliferative effects of isoflavonoids on prostate cancer cells and antitumorigenic effects in xenograft nude mice |
|
|
Professional Positions |
||
|
Medical Student, University of Florida College of Medicine |
||
|
Education |
||
|
Publications |
||
|
Rice L, Samedi VG, Medrano TA, Sweeney CA, Baker HV, Stenstrom A, Furman J, Shiverick KT. Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts. Prostate. 2002 Aug 1;52(3):201-12. abstract |
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Eric M. Sandberg, Ph.D. |
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|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 2000 - August 2004 (degree conferred December 2004) |
|
|
Dissertation Title |
Jak2 tyrosine kinase: New insights regarding structure, function, and pharmacology |
|
|
Professional Positions |
||
|
Postdoctoral Associate, Winship Cancer Center, Emory University, Atlanta, GA |
||
|
Education |
||
|
B.S., Microbiology & Cell Science, University of Florida |
||
|
Publications |
||
|
Sandberg EM, Ma X, VonDerLinden D, Godeny MD, Sayeski PP. Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1. J Biol Chem. 2004 Jan 16;279(3):1956-67. abstract |
||
|
VonDerLinden D, Ma X, Sandberg EM, Gernert K, Bernstein KE, Sayeski PP. Mutation of glutamic acid residue 1046 abolishes Jak2 tyrosine kinase activity. Mol Cell Biochem. 2002 Dec;241(1-2):87-94. abstract |
||
|
Sandberg EM, Sayeski PP. Jak2 Tyrosine Kinase Mediates Oxidative Stress-induced Apoptosis in Vascular Smooth Muscle Cells. J Biol Chem. 2004 Aug 13;279(33):34547-52. abstract |
||
|
Sandberg EM, Wallace TA, Godeny MD, VonDerLinden D, Sayeski PP. (2004) Jak2 tyrosine kinase: A true Jak of all trades? (Invited review) Cell Biochem Biophys. In Press. |
||
|
Sandberg EM, VonDerLinden D, Ostrov DA, Sayeski PP. (2004) Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction. Mol Cell Biochem. In Press. |
||
|
Abstracts Presented at Meetings during Graduate Studies |
||
|
Sandberg EM, VonDerLinden D, Ostrov DA, Sayeski PP. Identification of a biochemical interaction between Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 that is essential for angiotensin II-dependent activation of the Jak-STAT signaling pathway. (2003) Experimental Biology, San Diego, CA (Abstract) |
||
|
Sandberg EM, Ostrov DA, Sayeski PP. Structural analysis and ligand docking identifies a novel, potent small molecule inhibitor of Jak2 tyrosine kinase. (2004). Jaks and STATs: Development to Disease, British Colombia, Canada (Abstract) |
||
|
Sandberg EM, Sayeski PP. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. (2004) St. Jude's National Graduate Student Symposium, Memphis, TN (Oral Presentation) |
||
|
Sandberg EM, Sayeski PP. Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells. (June, 2004) European Society of Hypertension, Paris, France (Oral Presentation) |
||
|
Honors & Awards |
||
|
Professional memberships: Alpha Zeta Professional Fraternity, Golden Key National Honor Society, American Physiological Society |
||
|
2000: University of Florida Grinter Fellowship, $2000/year for 3 years |
||
|
2002: University of Florida Medical Guild Research Grant, $500 |
||
|
2003: American Heart Association Predoctoral Fellowship, $19,000/year for 2 years |
||
|
2004: Medical Guild Graduate Student Research Competition, 1st place in Physiology & Pharmacology, 3rd place overall |
||
|
2004: 14th Meeting of the European Society of Hypertension Accommodation Grant |
||
Kathleen W. Sellers, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 2000 - December 2004 |
|
|
Dissertation Title |
Role of brain soluble epoxide hydrolase on blood pressure regulation |
|
|
Professional Positions |
||
|
Education |
||
|
B.S., Biology, Winthrop University |
||
|
Publications |
||
|
Veerasingham SJ, Sellers KW, Raizada MK. Related Articles, Links Functional genomics as an emerging strategy for the investigation of central mechanisms in experimental hypertension. Prog Biophys Mol Biol. 2004 Feb-Apr;84(2-3):107-23. abstract |
||
|
Yang H, Francis SC, Sellers K, DeBarros M, Sun C, Sumners C, Ferrario CM, Katovich MJ, Muro AF, Raizada MK. Hypertension-linked decrease in the expression of brain gamma-adducin. Circ Res. 2002 Oct 4;91(7):633-9. abstract |
||
|
Metcalfe BL, Sellers KW, Jeng MJ, Huentelman MJ, Katovich MJ, Raizada MK. Gene therapy for cardiovascular disorders: is there a future? Ann N Y Acad Sci. 2001 Dec;953:31-42. abstract |
||
|
Sellers KW, Katovich MJ, Gelband CH, Raizada MK. Gene therapy to control hypertension: current studies and future perspectives. Am J Med Sci. 2001 Jul;322(1):1-6. abstract |
||
|
Honors & Awards |
||
|
American Heart Association Florida/Puerto Rico Affiliate Predoctoral Fellowship, 2003-2005 |
||
|
University of Florida Alumni Graduate Fellowship, 2000-2004 |
||
|
Honorary Mention, Beta Beta Beta Student Research Presentations, 2000 |
||
|
Trustees’ Scholarship, Winthrop University, 1996-2000 |
||
|
Abstracts Presented at Meetings Through Graduate Studies |
||
|
Sun C, Sellers KW, Raizada MK, Sumners C. Angiotensin II-induced increases in neuronal firing and blood pressure: Role of ROS. 2004 Gordon Research Conference on Angiotensin. |
||
|
Sellers KW, Veerasingham SJ, Francis SC, Raizada MK. Increased expression of soluble epoxide hydrolase in the brain of the spontaneously hypertensive rat. APS Meeting. 2003 FASEB J. 17: A1290, 823.5. (oral presentation) |
||
|
Sellers KW, Yang H, Boehlein SK, Schuster S, Ferrario C.M, Raizada, MK. Gene profiling reveals hypertension-associated decrease of Na+-K+-ATPase @ mRNA expression in the brain. APS Meeting. 2001 FASEB J. 632.6. (oral presentation) |
||
Nilanjana Sengupta, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 2001 - April 2005 |
|
|
Dissertation Title |
|
|
|
Education |
||
|
B.S., Biology, University of South Carolina |
||
| Professional Position Postdoctoral Fellow, Department of Ophthalmology, UF | ||
|
Publications |
||
|
Sengupta N, Caballero S, Mames RN, Timmers AM, Saban D, Grant MB. Preventing stem cell incorporation into choroidal neovascularization by targeting homing and attachment factors. Invest Ophthalmol Vis Sci. 2005 Jan;46(1):343-8. abstract |
||
|
Sengupta N, Caballero S. Mouse models of visual deficits. Nat Med. 2004;10:663; author reply 663. |
||
|
Caballero S, Sengupta N, Crafoord S, Lund R, Kruse FE, Young M, Grant MB. The many possible roles of stem cells in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2004 Jan;242(1):85-90. abstract |
||
|
Sengupta N, Caballero S, Mames RN, Butler JM, Scott EW, Grant MB. The role of adult bone marrow-derived stem cells in choroidal neovascularization. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):4908-13. abstract |
||
|
Abstracts Presented at Meetings |
||
|
Grant MB, Caballero S, Sengupta N, Mames RN, Scott EW. Stem cell recruitment and participation in choroidal neovascularization following rupture of Bruch's membrane. In: First Workshop on Cell Transplantation in Age-Related Macular Degeneration. Cologne, Germany: Graefes Arch Clin Exp Ophthalmol; 2004:54-55. |
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|
Grant MB, Sengupta N, Caballero S, Mames RN, Guthrie SM, Scott EW. Hemangioblast activity of stem cells as promoted by injury and modulated by nitric oxide in a model of retinal neovascularization. In: 63rd Scientific Sessions of the American Diabetes Association. New Orleans, LA: Diabetes; 2003:A20. |
||
|
Caballero S, Sengupta N, Mames RN, Scott EW, Grant MB. Stem cell recruitment and participation in choroidal neovascularization following rupture to Bruch’s membrane. Invest Ophthalmol Vis Sci 2003;44:ARVO Abstract 546. |
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|
Sengupta N, Caballero S, Scott EW, Mames RN, Guthrie, SM, Grant MB. Hemangioblast activity of stem cells as promoted by injury and modulated by nitric oxide in a model of retinal neovascularization. Invest Ophthalmol Vis Sci 2003;44:ARVO Abstract 2096. |
||
|
Sengupta N, Caballero S, Mames RN, Scott EW, Grant MB. Preventing stem cell incorporation into aberrant ocular neovascularization. Keystone Symposia (Stem Cells), January 2004, Keystone, CO. Abstract 129. |
||
|
Caballero S, Sengupta N, Mames RN, Scott EW, Grant MB. Hematopoietic stem cell contribution to rubeosis iridus. Keystone Symposia (Stem Cells), January 2004, Keystone, CO. Abstract 413. |
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|
Caballero S, Sengupta N, Mames RN, Scott EW, Grant MB. Hematopoietic Stem Cell Contribution to Neovascularization of the Iris. Invest Ophthalmol Vis Sci 2004;45:ARVO Abstract 502. |
||
|
Sengupta N, Caballero S, Mames RN, Scott EW, Grant MB. Preventing Stem Cell Incorporation into Choroidal Neovascularization. Invest Ophthalmol Vis Sci 2004;45:ARVO Abstract 2233. |
||
|
Honors & Awards |
||
|
National Eye Institute Travel Grant ($700) to attend and present a paper at the Annual Meeting (2004) of the Association for Research in Vision and Ophthalmology (ARVO). |
||
Wenyin Shi, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 1998 - August 2002 |
|
|
Dissertation Title |
Modulation of tumor angiogenesis through the use of antisense oligodeoxynucleotides targeted to VEGF and BFGF |
|
|
Professional Positions |
||
|
Postdoctoral Associate, University of Florida College of Medicine, Radiation Oncology |
||
|
Education |
||
|
Publications |
||
|
Brazelle WD, Shi W, Siemann DW. VEGF-associated tyrosine kinase inhibition increases the tumor response to single and fractionated dose radiotherapy. Int J Radiat Oncol Biol Phys. 2006 Jul 1;65(3):836-41. abstract |
||
|
Shi W, Siemann DW. S imultaneous targeting of VEGF message and VEGF receptor signaling as a therapeutic anticancer approach. Anticancer Res. 2004 Jan-Feb;24(1):213-8. abstract |
||
|
Shi W, Teschendorf C, Muzyczka N, Siemann DW. Gene therapy delivery of endostatin enhances the treatment efficacy of radiation. Radiother Oncol. 2003 Jan;66(1):1-9. abstract |
||
|
Siemann DW, Shi W. Targeting the tumor blood vessel network to enhance the efficacy of radiation therapy. Semin Radiat Oncol. 2003 Jan;13(1):53-61. Review. abstract |
||
|
Shi W, Siemann DW. Inhibition of renal cell carcinoma angiogenesis and growth by antisense oligonucleotides targeting vascular endothelial growth factor. Br J Cancer. 2002 Jul 1;87(1):119-26. abstract |
||
|
Shi W, Teschendorf C, Muzyczka N, Siemann DW. Adeno-associated virus-mediated gene transfer of endostatin inhibits angiogenesis and tumor growth in vivo. Cancer Gene Ther. 2002 Jun;9(6):513-21. abstract |
||
|
Honors & Awards |
||
|
Graduate Fellowship for Outstanding Reseach, UF College of Medicine, 2001 |
||
Yi Tang, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
M. Ian Phillips, Ph.D. |
|
|
Department |
||
|
Enrolled |
August 1999 - May 2003 |
|
|
Dissertation Title |
Vigilant vector: A
hypoxia inducible and heart-specific double vector system for
cardioprotection |
|
|
Professional Positions |
||
|
Education |
||
|
B.Med., Clinical Medicine, Shanghai Medical University, Shanghai, P.R. China |
||
|
Residency training, Department of Cardiology, Zhongshan Hospital, Shanghai Medical University, Shanghai, P.R. China |
||
|
Publications |
||
|
Tang YL, Tang Y, Zhang YC, Qian K, Shen L, Phillips MI. Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension. 2004 Apr;43(4):746-51. abstract |
||
|
Tang YL, Zhao Q, Zhang YC, Cheng L, Liu M, Shi J, Yang YZ, Pan C, Ge J, Phillips MI. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept. 2004 Jan 15;117(1):3-10. abstract |
||
|
Tang Y, Schmitt-Ott K, Qian K, Kagiyama S, Phillips MI. Vigilant vectors: adeno-associated virus with a biosensor to switch on amplified therapeutic genes in specific tissues in life-threatening diseases. Methods. 2002 Oct;28(2):259-66. abstract |
||
|
Tang Y, Jackson M, Qian K, Phillips MI. Hypoxia inducible double plasmid system for myocardial ischemia gene therapy. Hypertension. 2002 Feb;39(2 Pt 2):695-8. abstract |
||
|
Phillips MI, Tang Y, Schmidt-Ott K, Qian K, Kagiyama S. Vigilant vector: heart-specific promoter in an adeno-associated virus vector for cardioprotection. Hypertension. 2002 Feb;39(2 Pt 2):651-5. abstract |
||
|
Honors & Awards |
||
|
Graduate Fellowship for Outstanding Reseach, UF College of Medicine, 2002 |
||
David G. Taylor, Ph.D. |
||
|
Advanced Concentration |
||
|
Mentor |
||
|
Department |
||
|
Enrolled |
August 1999 - August 2004 |
|
|
Dissertation Title |
Roles of sarcoplasmic reticular Ca(2+) ATPase and action potential duration in normal and hypertrophied rat myocardium |
|
|
Professional Positions |
||
|
Postdoctoral Associate, Dept. of Pharmacology & Therapeutics, UF College of Medicine |
||
|
Education |
||
|
B.S., Biological Sciences, University of Southern Mississippi |
||
|
Publications |
||
|
Metcalfe BL, Huentelman MJ, Parilak LD, Taylor DG, Katovich MJ, Knot HJ, Sumners C, Raizada MK. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension. 2004 Jun;43(6):1233-8. abstract |
||
|
Taylor DG, Parilak LD, LeWinter MM, Knot HJ. Quantification of the rat left ventricle force and Ca(2+)-frequency relationships: similarities to dog and human. Cardiovasc Res. 2004 Jan 1;61(1):77-86. abstract |
||
|
Walls SC, Taylor DG, Wilson CM. Interspecific differences in susceptibility to competition and predation in a species-pair of larval amphibians. Herpetologica. 2002;58(1):104-118. |
||
|
Abstracts Presented at Meetings Through Graduate Studies |
||
|
Parilak LD, Taylor DG, Song E, Knot HJ. From hypertrophy to heart failure: Key events emerging from a parallel study in humasn and rats. American Heart Association, 2003. |
||
|
Taylor DG, Parilak LD, Knot HJ. Quantification of calcium and force frequency in rat heart compared to humans and dogs. FASEB 2003. |
||
|
Taylor DG, Parilak LD, Knot HJ. Effects of cardiac hypertrophy without systemic hypertension on cardiac contractility in rat and human. FASEB 2003. |
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Parilak LD, Taylor DG, Knot HJ. Effects of aging and hypertension on cardiac contractility. FASEB 2003. |
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Honors & Awards |
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American Heart Association Predoctoral Fellowship, 2003-2005 |
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Alumni Fellowship, 1999-2003 |
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Outstanding Senior in Biology, Beta Beta Beta Biological Honor Society, University of Southern Mississippi, 2000 |
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Honorable Mention, Graduate Research Fellowship, National Sciecne Foundation, 1999 |
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Presidential Fellowship, University of Southern Mississippi, 1995-1999 |
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National Merit Finalist, 1995 |
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J. Keith Tolson, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1997 - August 2004 (degree conferred December 2004) |
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Dissertation Title |
Heat shock proteins and protection from hepatotoxicity |
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Professional Positions |
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Senior Toxicologist, Geosyntec |
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Education |
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B.S., Food Science, University of Florida |
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Publications |
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Halmes NC, Roberts SM, Tolson JK, Portier CJ. Reevaluating cancer risk estimates for short-term exposure scenarios. Toxicol Sci. 2000 Nov;58(1):32-42. abstract |
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Tolson JK, Moye HA, Toth JP. Effect of temperature and humidity on the formation of dibutylurea in benlate fungicide. J Agric Food Chem. 1999 Mar;47(3):1217-22. abstract |
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Hart CM, Tolson JK, Block ER. Quantitative fatty acid analyses in cultured porcine pulmonary artery endothelial cells: the combined effects of fatty acid supplementation and oxidant exposure. J Cell Physiol. 1992 Oct;153(1):76-87. abstract |
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Bhat GB, Tinsley SB, Tolson JK, Patel JM, Block ER. Hypoxia increases the susceptibility of pulmonary artery endothelial cells to hydrogen peroxide injury. J Cell Physiol. 1992 May;151(2):228-38. abstract |
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Hart CM, Tolson JK, Block ER. Supplemental fatty acids alter lipid peroxidation and oxidant injury in endothelial cells. Am J Physiol. 1991 Jun;260(6 Pt 1):L481-8. abstract |
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Hart CM, Tolson JK, Block ER. Fatty acid supplementation protects pulmonary artery endothelial cells from oxidant injury. Am J Respir Cell Mol Biol. 1990 Nov;3(5):479-89. abstract |
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Tiffany Wallace, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2001 - December 2005 |
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Dissertation Title |
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Professional Positions |
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Education B.S., Biology, Monmouth College |
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Publications |
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Wallace TA, Sayeski PP. Jak2 tyrosine kinase: a mediator of both housekeeping and ligand-dependent gene expression? Cell Biochem Biophys. 2006;44(2):213-22. abstract |
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Sandberg EM, Wallace TA, Godeny MD, Vonderlinden D, Sayeski PP. Jak2 tyrosine kinase: a true jak of all trades? Cell Biochem Biophys. 2004;41(2):207-32. abstract |
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Wallace TA, VonDerLinden D, He K, Frank SJ, Sayeski PP. Microarray analyses identify JAK2 tyrosine kinase as a key mediator of ligand-independent gene expression. Am J Physiol Cell Physiol. 2004 Oct;287(4):C981-91. Epub 2004 Jun 9. abstract |
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Fei Wang, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2001 - December 2005 | |
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Dissertation Title |
Acceleration of Murine Systemic Lupus Erythematosus (SLE) by Exposure to the Organochlorine Pesticide Chlordecone |
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Professional Positions |
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Education |
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B.S., Science, Shanghai Jiao Tong University |
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Publications |
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Sobel ES, Wang F, Butfiloski E, Croker B, Roberts SM. Comparison of chlordecone effects on autoimmunity in (NZBxNZW) F(1) and BALB/c mice. Toxicology. 2006 Feb 1;218(2-3):81-9. Epub 2005 Nov 22. abstract |
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Ketcham C, Wang F, Fisher SZ, Ercan A, Van Der Wel H, Locke RD, Ud-Doulah k S, Matta KL, West CM. Specificity of a soluble UDP-galactose:fucoside a1,3 galactosyltransferase that modifies the cytoplasmic glycoprotein Skp1 in dictyostelium. J Biol Chem. 2004 May 3 (in press) |
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Wang F, Metcalf T, van der Wel H, West CM. Initiation of mucin-type O-glycosylation in dictyostelium is homologous to the corresponding step in animals and is important for spore coat function. J Biol Chem. 2003 Dec 19;278(51):51395-407. abstract |
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Abstracts Presented at Meetings Through Graduate Studies |
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Honors & Awards |
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| Lupus Foundation of America, Gina Finzi Memorial Student Summer Fellowship Award, 2004 | ||
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American Society of Pharmacology and Experimental Therapeutics, Graduate Student Travel Award 2004 |
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Jared T. Wilsey, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - August 2003 |
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Dissertation Title |
Potent anorexic and lipopenic effects of central leptin gene therapy are blocked by diet-induced obesity: Evidence for impaired leptin receptor expression/signal transduction in obesity and reversal by caloric restriction (full text) |
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Professional Positions |
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Research Health Scientist, VA Medical Center, Gainesville, FL |
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Education |
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B.S., Nutritional Chemistry, Cornell University, Ithaca, NY |
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Publications |
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Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol. 2004 Jul;182(1):123-32. abstract |
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Wilsey J, Scarpace PJ. Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression. J Endocrinol. 2004 May;181(2):297-306. abstract |
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Wilsey J, Zolotukhin S, Prima V, Scarpace PJ. Central leptin gene therapy fails to overcome leptin resistance associated with diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2003 Nov;285(5):R1011-20. abstract |
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Wilsey J, Zolotukhin S, Prima V, Shek EW, Matheny MK, Scarpace PJ. Hypothalamic delivery of doxycycline-inducible leptin gene allows for reversible transgene expression and physiological responses. Gene Ther. 2002 Nov;9(22):1492-9. abstract |
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Zhang Y, Wilsey JT, Frase CD, Matheny MM, Bender BS, Zolotukhin S, Scarpace PJ. Peripheral but not central leptin prevents the immunosuppression associated with hypoleptinemia in rats. J Endocrinol. 2002 Sep;174(3):455-61. abstract |
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Honors & Awards |
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University of Florida Presidential and Alumni Fellowships |
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Ethan Sims Young Investigator Award Finalist, North American Association for the Study of Obesity, 2001 |
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University of Florida Medical Guild Graduate Student Research Competition, First Place, 2003 |
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Yuan C. Zhang, Ph.D. |
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Advanced Concentration |
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Mentor |
M. Ian Phillips, Ph.D. |
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Department |
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Enrolled |
August 1996 - August 2000 |
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Dissertation Title |
A Novel B1- blocker based on antisense oligonucleotides: A new gene therapy approach in hypertension, cardiac hypertrophy and myocardial ischemia |
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Professional Positions |
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Education |
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Publications |
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Tang YL, Tang Y, Zhang YC, Qian K, Shen L, Phillips MI. Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension. 2004 Apr;43(4):746-51. abstract |
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Tang YL, Zhao Q, Zhang YC, Cheng L, Liu M, Shi J, Yang YZ, Pan C, Ge J, Phillips MI. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept. 2004 Jan 15;117(1):3-10. abstract |
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Kagiyama S, Eguchi S, Frank GD, Inagami T, Zhang YC, Phillips MI. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation. 2002 Aug 20;106(8):909-12. abstract |
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Chen H, Zhang YC, Li D, Phillips MI, Mehta P, Shi M, Mehta JL. Protection against myocardial dysfunction induced by global ischemia-reperfusion by antisense-oligodeoxynucleotides directed at beta(1)-adrenoceptor mRNA. J Pharmacol Exp Ther. 2000 Aug;294(2):722-7. abstract |
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Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation. 2000 Feb 15;101(6):682-8. abstract |
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Tang X, Mohuczy D, Zhang YC, Kimura B, Galli SM, Phillips MI. Intravenous angiotensinogen antisense in AAV-based vector decreases hypertension. Am J Physiol. 1999 Dec;277(6 Pt 2):H2392-9. abstract |
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Phillips MI, Zhang YC. Basic principles of using antisense oligonucleotides in vivo. Methods Enzymol. 2000;313:46-56. abstract |
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Li DY, Zhang YC, Philips MI, Sawamura T, Mehta JL. Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation. Circ Res. 1999 May 14;84(9):1043-9. abstract |
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Yang BC, Phillips MI, Zhang YC, Kimura B, Shen LP, Mehta P, Mehta JL. Critical role of AT1 receptor expression after ischemia/reperfusion in isolated rat hearts: beneficial effect of antisense oligodeoxynucleotides directed at AT1 receptor mRNA. Circ Res. 1998 Sep 7;83(5):552-9. abstract |
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last revised 11/3/06 wtm
