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Physiology & Pharmacology Alumni |
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Physiology & Pharmacology Alumni |
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Physiology & Pharmacology |
Christopher J. Bowman, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1996 - May 2002 |
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Dissertation Title |
Gene regulation in teleosts by estradiol and estrogen mimics |
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Professional Positions |
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CIIT Centers for Health Research, Research Triangle Park, NC |
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Education |
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B.S., University of Florida |
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Publications |
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Bowman CJ, Barlow NJ, Turner KJ, Wallace DG, Foster PM. Effects of in utero exposure to finasteride on androgen-dependent reproductive development in the male rat. Toxicol Sci. 2003 Aug;74(2):393-406. abstract |
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Turner KJ, McIntyre BS, Phillips SL, Barlow NJ, Bowman CJ, Foster PM. Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron. Toxicol Sci. 2003 Jul;74(1):114-28. abstract |
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Bowman CJ, Kroll KJ, Gross TG, Denslow ND. Estradiol-induced gene expression in largemouth bass (Micropterus salmoides). Mol Cell Endocrinol. 2002 Oct 31;196(1-2):67-77. abstract |
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Hemmer MJ, Bowman CJ, Hemmer BL, Friedman SD, Marcovich D, Kroll KJ, Denslow ND. Vitellogenin mRNA regulation and plasma clearance in male sheepshead minnows, (Cyprinodon variegatus) after cessation of exposure to 17 beta-estradiol and p-nonylphenol. Aquat Toxicol. 2002 Jul;58(1-2):99-112. abstract |
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Denslow ND, Lee HS, Bowman CJ, Hemmer MJ, Folmar LC. Multiple responses in gene expression in fish treated with estrogen. Comp Biochem Physiol B Biochem Mol Biol. 2001 Jun;129(2-3):277-82. abstract |
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Hemmer MJ, Hemmer BL, Bowman CJ, Kroll KJ, Folmar LC, Marcovich D, Hoglund MD, Denslow ND. Effects of p-nonylphenol, methoxychlor, and endosulfan on vitellogenin induction and expression in sheepshead minnow (Cyprinodon variegatus). Environ Toxicol Chem. 2001 Feb;20(2):336-43. abstract |
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Denslow ND, Bowman CJ, Ferguson RJ, Lee HS, Hemmer MJ, Folmar LC. Induction of gene expression in sheepshead minnows (Cyprinodon variegatus) treated with 17beta-estradiol, diethylstilbestrol, or ethinylestradiol: the use of mRNA fingerprints as an indicator of gene regulation. Gen Comp Endocrinol. 2001 Mar;121(3):250-60. abstract |
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Bowman CJ, Kroll KJ, Hemmer MJ, Folmar LC, Denslow ND. Estrogen-induced vitellogenin mRNA and protein in sheepshead minnow (Cyprinodon variegatus). Gen Comp Endocrinol. 2000 Dec;120(3):300-13. abstract |
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Funkenstein B, Bowman CJ, Denslow ND, Cardinali M, Carnevali O. Contrasting effects of estrogen on transthyretin and vitellogenin expression in males of the marine fish, Sparus aurata. Mol Cell Endocrinol. 2000 Sep 25;167(1-2):33-41. abstract |
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Folmar LC, Hemmer M, Hemmer R, Bowman C, Kroll K, Denslow ND. Comparative estrogenicity of estradiol, ethynyl estradiol and diethylstilbestrol in an in vivo, male sheepshead minnow (Cyprinodon variegatus), vitellogenin bioassay. Aquat Toxicol. 2000 May 1;49(1-2):77-88. abstract |
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Honors & Awards |
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Graduate Fellowship for Outstanding Reseach, UF College of Medicine, 2000 |
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Jonathan D. Bui, M.D., Ph.D. |
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Advanced Concentration |
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Mentor |
M. Ian Phillips, Ph.D. & Stephen J. Blackband, Ph.D. |
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Department |
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Enrolled |
August 1996 - August 2000 (Ph.D.) |
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Dissertation Title |
Quantitative NMR studies of perfused brain slices |
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COS Profile |
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Professional Positions |
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Clinical Fellow, Harvard University, Beth Israel, Medicine |
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Education |
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B.S., Zoology, B.S., Biophysical Chemistry and Molecular Biology, University of Florida |
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Publications |
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Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation. 2000 Feb 15;101(6):682-8. abstract |
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Forder JR, Bui JD, Buckley DL, Blackband SJ. MR imaging measurement of compartmental water diffusion in perfused heart slices. Am J Physiol Heart Circ Physiol. 2001 Sep;281(3):H1280-5. abstract |
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Hsu EW, Buckley DL, Bui JD, Blackband SJ, Forder JR. Two-component diffusion tensor MRI of isolated perfused hearts. Magn Reson Med. 2001 Jun;45(6):1039-45. abstract |
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Shi J, Bui JD, Yang SH, He Z, Lucas TH, Buckley DL, Blackband SJ, King MA, Day AL, Simpkins JW. Estrogens decrease reperfusion-associated cortical ischemic damage: an MRI analysis in a transient focal ischemia model. Stroke. 2001 Apr;32(4):987-92. abstract |
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Zhang YC, Bui JD, Shen L, Phillips MI. Antisense inhibition of beta(1)-adrenergic receptor mRNA in a single dose produces a profound and prolonged reduction in high blood pressure in spontaneously hypertensive rats. Circulation. 2000 Feb 15;101(6):682-8. abstract |
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Blackband SJ, Buckley DL, Bui JD, Phillips MI. NMR microscopy--beginnings and new directions. MAGMA. 1999 Dec;9(3):112-6. Review. abstract |
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Bui JD, Zelles T, Lou HJ, Gallion VL, Phillips MI, Tan W. Probing intracellular dynamics in living cells with near-field optics. J Neurosci Methods. 1999 Jul 1;89(1):9-15. abstract |
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Buckley DL, Bui JD, Phillips MI, Blackband SJ. MRI measurement of cell volume fraction in the perfused rat hippocampal slice. Magn Reson Med. 1999 Sep;42(3):603-7. abstract |
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Bui JD, Buckley DL, Phillips MI, Blackband SJ. Nuclear magnetic resonance imaging measurements of water diffusion in the perfused hippocampal slice during N-methyl-D-aspartate-induced excitotoxicity. Neuroscience. 1999;93(2):487-90. abstract |
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Bui JD, Nammari DR, Buckley DL, Inglis BA, Silver XS, Mareci TH, Phillips MI. In vivo dynamics and distribution of intracerebroventricularly administered gadodiamide, visualized by magnetic resonance imaging. Neuroscience. 1999 Mar;90(3):1115-22. abstract |
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Buckley DL, Bui JD, Phillips MI, Zelles T, Inglis BA, Plant HD, Blackband SJ. The effect of ouabain on water diffusion in the rat hippocampal slice measured by high resolution NMR imaging. Magn Reson Med. 1999 Jan;41(1):137-42. abstract |
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Blackband SJ, Bui JD, Buckley DL, Zelles T, Plant HD, Inglis BA, Phillips MI. MR microscopy of perfused brain slices. Magn Reson Med. 1997 Dec;38(6):1012-5. abstract |
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Bui JD, Kimura B, Phillips MI. Losartan potassium, a nonpeptide antagonist of angiotensin II, chronically administered p.o. does not readily cross the blood-brain barrier. Eur J Pharmacol. 1992 Aug 14;219(1):147-51. abstract |
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Xuefang Cao, Ph.D. |
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Advanced Concentration |
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Mentor |
William Stratford May, Jr., M.D., Ph.D. |
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Department |
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Enrolled |
August 1999 - December 2003 |
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Dissertation Title |
Cleavage of Bas to Pis Bax facilitates stress-induced apoptosis |
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Professional Positions |
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Education |
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Publications |
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Cao X, Deng X, May WS. Cleavage of Bax to p18 Bax accelerates stress-induced apoptosis, and a cathepsin-like protease may rapidly degrade p18 Bax. Blood. 2003 Oct 1;102(7):2605-14. abstract |
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Shuzhen Chen, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
TGF-beta-1 regulation of chemokine receptors in rat microglia and human macrophages (full text) |
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Professional Positions |
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Postdoctoral Associate, Harvard Medical School |
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Education |
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B.S., College Of Life Sciences, Beijing University |
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Publications |
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Davis CN, Chen S, Boehme SA, Bacon KB, Harrison JK. Chemokine receptor binding and signal transduction in native cells of the central nervous system. Methods. 2003 Apr;29(4):326-34. abstract |
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Chen S, Luo D, Streit WJ, Harrison JK. TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. J Neuroimmunol. 2002 Dec;133(1-2):46-55. abstract |
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Harrison JK, Fong AM, Swain PA, Chen S, Yu YR, Salafranca MN, Greenleaf WB, Imai T, Patel DD. Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. J Biol Chem. 2001 Jun 15;276(24):21632-41. abstract |
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Honors & Awards |
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Best Thesis of the Department of Cell Biology and Genetics, Beijing University, 1999 |
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Gangsong Scholarshop, Beijing University, 1998 |
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Xiyue Scholarship, Beijing University, 1997 |
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Tan Jiazhen (C.C. Tan) Life Science Scholarship |
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Christopher N. Davis, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - August 2004 |
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Dissertation Title |
Mammalian and viral chemokines provide insight into the mechanism of chemokine receptor activation (full text) |
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Professional Positions |
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Postdoctoral Associate, Dept. of Neuropharmacology, The Scripps Research Institute, San Diego, CA |
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Education |
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B.S., Neurobiological Sciences and Psychology, University of Florida |
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Publications |
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Streit WJ, Davis CN, Harrison JK. Role of fractalkine (CX3CL1) in regulating neuron-microglia interactions: development of viral-based CX3CR1 antagonists. Curr Alzheimer Res. 2005 Apr;2(2):187-9. abstract |
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Davis CN, Zujovic V, Harrison JK. vMIP-II and fractalkine (CX3CL1) chimeras identify molecular determinants of affinity, efficacy, and selectivity at CX3CR1. Mol Pharmacol. 2004 Dec;66(6):1431-9. abstract |
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Davis CN, Chen S, Boehme SA, Bacon KB, Harrison JK. Chemokine receptor binding and signal transduction in native cells of the central nervous system. Methods. 2003 Apr;29(4):326-34. abstract |
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Ileana Montanez-Clemente Elder, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - August 2004 |
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Dissertation Title |
Kinetic and structural studies on the activation of the proton transfer in catalysis by carbonic anhydrase |
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Professional Positions |
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Education |
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B.S., Industrial Chemistry, University of Puerto Rico |
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Publications |
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Elder I, Han S, Tu C, Steele H, Laipis PJ, Viola RE, Silverman DN. Activation of carbonic anhydrase II by active-site incorporation of histidine analogs. Arch Biochem Biophys. 2004 Jan 15;421(2):283-9. abstract |
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An H, Tu C, Duda D, Montanez-Clemente I, Math K, Laipis PJ, McKenna R, Silverman DN. Chemical rescue in catalysis by human carbonic anhydrases II and III. Biochemistry. 2002 Mar 5;41(9):3235-42. abstract |
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Montanez-Clemente I, Alvira E, Macias M, Ferrer A, Fonceca M, Rodriguez J, Gonzalez A, Barletta G. Enzyme activation in organic solvents: co-lyophilization of subtilisin Carlsberg with methyl-beta-cyclodextrin renders an enzyme catalyst more active than the cross-linked enzyme crystals. Biotechnol Bioeng. 2002 Apr 5;78(1):53-9. abstract |
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Martinez SG, Alvira E, Cordero LV, Ferrer A, Montanes-Clemente I, Barletta G. High initial activity but low storage stability observed for several preparations of subtilisin Carslberg suspended in organic solvents. Biotechnol Prog. 2002 Nov-Dec;18(6):1462-6. abstract |
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Santos AM, Montañez Clemente I, Barletta G, Griebenow K. Activation of serine protease subtilisin Carlsberg in organic solvents: combined effect of methyl-ß-cyclodextrin and water. Biotech Letters. 1999 Dec;21(12):1113-8. |
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Griebenow K, Laureano YD, Santos AM, Clemente IM, Rodriguez L, Vidal MW, Barletta G. Improved enzyme activity and enantioselectivity in organic solvents by methyl--cyclodextrin. J Am Chem Soc. 1999;121(36); 8157-8163. |
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Jenafer Evans, Ph.D. |
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Advanced Concentration |
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Mentor |
C. H. Gelband, Ph.D. |
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Department |
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Enrolled |
August 1996 - May 2001 |
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Dissertation Title |
Angiotensin II modulation of neuronal calcium current (full text) |
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Professional Positions |
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Postdoctoral Associate, Calcium Signals Laboratory (David Yue, M.D., Ph.D.), Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD |
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Education |
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B.S., Chemistry, University of Virginia |
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Publications |
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Evans J, Sumners C, Moore J, Huentelman MJ, Deng J, Gelband CH, Shaw G. Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol. 2002 Feb;87(2):1076-85. abstract |
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Evans J, Gelband CH. A novel Ca2+ channel in vascular smooth muscle? Circ Res. 1999 Oct 1;85(7):651-2. Review. abstract |
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Honors & Awards |
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Outstanding Chemistry Student Award, University of Virginia, 1996 |
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Melissa A. Fleegal, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1997 - August 2002 |
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Dissertation Title |
Angiotensin II modulation of neuronal intracellular signaling cascades regulates short-term and long-term physiological responses (full text) |
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Professional Positions |
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Education |
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B.S., Biology, Lebanon Valley College, PA |
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Publications |
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Fleegal MA, Sumners C. Angiotensin II induction of AP-1 in neurons requires stimulation of PI3-K and JNK. Biochem Biophys Res Commun. 2003 Oct 17;310(2):470-7. abstract |
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Fleegal MA, Sumners C. Drinking behavior elicited by central injection of angiotensin II: roles for protein kinase C and Ca2+/calmodulin-dependent protein kinase II. Am J Physiol Regul Integr Comp Physiol. 2003 Sep;285(3):R632-40. abstract |
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Marcus JS, Karackattu SL, Fleegal MA, Sumners C. Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB. Glia. 2003 Jan 15;41(2):152-60. abstract |
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Sumners C, Fleegal MA, Zhu M. Angiotensin AT1 receptor signalling pathways in neurons. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):483-90. Review. abstract |
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Busche S, Gallinat S, Fleegal MA, Raizada MK, Sumners C. Novel role of macrophage migration inhibitory factor in angiotensin II regulation of neuromodulation in rat brain. Endocrinology. 2001 Nov;142(11):4623-30. abstract |
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Baghdoyan HA, Lydic R, Fleegal MA. M2 muscarinic autoreceptors modulate acetylcholine release in the medial pontine reticular formation. J Pharmacol Exp Ther. 1998 Sep;286(3):1446-52. abstract |
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Roth MT, Fleegal MA, Lydic R, Baghdoyan HA. Pontine acetylcholine release is regulated by muscarinic autoreceptors. Neuroreport. 1996 Nov 25;7(18):3069-72. abstract |
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Honors & Awards |
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Graduate Fellowship for Outstanding Reseach, UF College of Medicine, 2000 |
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Monica L. Gardon, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
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August 1996 - December 2003 |
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Dissertation Title |
Functional remodeling of the renal and cerebral resistance vasculature in hypertensive rats |
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Professional Positions |
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Education |
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Publications |
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Gardon M, Raizada MK, Katovich MJ, Berecek KH, Gelband CH. Gene therapy for hypertension and restenosis. J Renin Angiotensin Aldosterone Syst. 2000 Sep;1(3):211-6. Review. |
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Gardon ML, Gelband CH, Katovich MJ, Raizada MK. The potential use of gene therapy in the control of hypertension. Drugs Today (Barc). 1999 Dec;35(12):925-30. abstract |
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Damian Giroux, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - May 2002 |
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Dissertation Title |
Estrogen influences on fetal CNS cyclooxygenase and nitric oxide synthase isoforms in response to cerebral hypoperfusion |
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Professional Positions |
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Education |
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M.S., University of Florida |
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Publications |
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Wood CE, Giroux D, Gridley K. Fetal brain regional responses to cerebral hypoperfusion: modulation by estrogen. Brain Res. 2003 Dec 12;993(1-2):84-9. abstract |
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Wood CE, Giroux D. Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheep. J Physiol. 2003 Jun 1;549(Pt 2):573-81. abstract |
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Deauseault D, Giroux D, Wood CE. Ontogeny of immunoreactive prostaglandin endoperoxide synthase isoforms in ovine fetal pituitary, hypothalamus and brainstem. Neuroendocrinology. 2000 May;71(5):287-91. abstract |
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William B. Greenleaf, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
Proton transfer in catalysis by iron and manganese superoxide dismutase |
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Professional Positions |
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Postdoctaral Associate, University of Colorado Health Science Center |
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Education |
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Publications |
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Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Role of hydrogen bonding in the active site of human manganese superoxide dismutase. Biochemistry. 2004 Jun 8;43(22):7038-45. abstract |
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Hearn AS, Fan L, Lepock JR, Luba JP, Greenleaf WB, Cabelli DE, Tainer JA, Nick HS, Silverman DN. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase. J Biol Chem. 2004 Feb 13;279(7):5861-6. abstract |
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Greenleaf WB, Silverman DN. Activation of the proton transfer pathway in catalysis by iron superoxide dismutase. J Biol Chem. 2002 Dec 20;277(51):49282-6. abstract |
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Honors and Awards |
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Alumni Graduate Fellowship, University of Florida |
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Mercz Index Award, Florida State University |
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Phi Beta Kappa, Alpha of Florida Chapter, Florida State University |
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Golden Key National Honor Society, Florida State University |
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National Merit Scholarship, National Merit Corporation, Florida State University |
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National Merit Scholarship, Florida State University |
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Renita Handayani, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - December 2004 |
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Dissertation Title |
Prospective cancer chemoprevention agents: Mechanisms of the effects of soy isoflavone and vitamin E on the regulation of p21 (WAF1/CIP1) gene expression |
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Professional Positions |
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Education |
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B.S., Pharmacy |
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Publications |
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Ason B, Handayani R, Williams CR, Bertram JG, Hingorani MM, O'Donnell M, Goodman MF, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. J Biol Chem. 2003 Mar 21;278(12):10033-40. abstract |
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Amy S. Hearn, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1996 - May 2001 |
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Dissertation Title |
Product inhibition in human manganese superoxide dismutase |
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Professional Positions |
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Postdoctoral Associate, American Lung Association Fellow, Dept. Neuroscience, UF College of Medicine |
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Education |
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B.S., University of Florida |
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Publications |
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Greenleaf WB, Perry JJ, Hearn AS, Cabelli DE, Lepock JR, Stroupe ME, Tainer JA, Nick HS, Silverman DN. Role of hydrogen bonding in the active site of human manganese superoxide dismutase. Biochemistry. 2004 Jun 8;43(22):7038-45. abstract |
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Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition. J Biol Chem. 2004 Mar 26;279(13):12769-76. abstract |
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Hearn AS, Fan L, Lepock JR, Luba JP, Greenleaf WB, Cabelli DE, Tainer JA, Nick HS, Silverman DN. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase. J Biol Chem. 2004 Feb 13;279(7):5861-6. abstract |
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Hearn AS, Stroupe ME, Cabelli DE, Ramilo CA, Luba JP, Tainer JA, Nick HS, Silverman DN. Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel. Biochemistry. 2003 Mar 18;42(10):2781-9. abstract |
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Hearn AS, Stroupe ME, Cabelli DE, Lepock JR, Tainer JA, Nick HS, Silverman DN. Kinetic analysis of product inhibition in human manganese superoxide dismutase. Biochemistry. 2001 Oct 9;40(40):12051-8. abstract |
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Cabelli DE, Guan Y, Leveque V, Hearn AS, Tainer JA, Nick HS, Silverman DN. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase. Biochemistry. 1999 Sep 7;38(36):11686-92. abstract |
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Hearn AS, Tu C, Nick HS, Silverman DN. Characterization of the product-inhibited complex in catalysis by human manganese superoxide dismutase. J Biol Chem. 1999 Aug 27;274(35):24457-60. abstract |
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Yi Hua, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - December 2002 |
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Dissertation Title |
Progesterone and corticosteroid interaction during pregnancy in ewes |
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Professional Positions |
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Education |
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Publications |
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Richards EM, Hua Y, Keller-Wood M. Pharmacology and physiology of ovine corticosteroid receptors. Neuroendocrinology. 2003 Jan;77(1):2-14. abstract |
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Matthew J. Huentelman, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - December 2003 |
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Dissertation Title |
HIV-1 based viral vector development for gene transfer to the cardiovascular system (full text) |
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Professional Positions |
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Education |
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B.S., Ohio State University, Columbus, OH |
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Publications |
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Huentelman MJ, Zubcevic J, Hernandez Prada JA, Xiao X, Dimitrov DS, Raizada MK, Ostrov DA. Structure-Based Discovery of a Novel Angiotensin-Converting Enzyme 2 Inhibitor. Hypertension. 2004 Oct 18;44:1-4. abstract |
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Metcalfe BL, Huentelman MJ, Parilak LD, Taylor DG, Katovich MJ, Knot HJ, Sumners C, Raizada MK. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension. 2004 Jun;43(6):1233-8. abstract |
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Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK. Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics. 2003 Feb 6;12(3):221-8. abstract |
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Huentelman MJ, Reaves PY, Katovich MJ, Raizada MK. Large-scale production of retroviral vectors for systemic gene delivery. Methods Enzymol. 2002;346:562-73. |
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Metcalfe BL, Sellers KW, Jeng MJ, Huentelman MJ, Katovich MJ, Raizada MK. Gene therapy for cardiovascular disorders: is there a future? Ann N Y Acad Sci. 2001 Dec;953:31-42. Review. abstract |
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Pachori AS, Huentelman MJ, Francis SC, Gelband CH, Katovich MJ, Raizada MK. The future of hypertension therapy: sense, antisense, or nonsense? Hypertension. 2001 Feb;37(2 Part 2):357-64. Review. abstract |
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Susan E. LeFrancois, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - December 2004 |
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Dissertation Title |
A Structure Activity Investigation of Benzylidene Anabaseine Interactions with the Alpha7 Nicotinic Acetylcholine Receptor |
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Professional Positions |
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Education |
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|
B.S., University of South Florida |
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Publications |
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Kem WR, Wildeboer K, LeFrancois S, Raja M, Marszalec W, Braekman JC. Nicotinic receptor inhibition by Tetraponera ant alkaloids. Cell Mol Neurobiol. 2004 Aug;24(4):535-51. abstract |
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Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol Pharmacol. 2004 Jan;65(1):56-67. abstract |
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Gang Li, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - August 2003 |
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Dissertation Title |
Effects of the melanocortin agonist melanotan II, central pro-opiomelanocortin and interleukin-6 gene therapies on the regulation of body weight and energy homeostasis (full text) |
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Professional Positions |
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Education |
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B.Med., Zhejiang University School of Medicine, P.R. China |
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M.D., Peking Union Medical College, P.R. China |
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Publications |
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Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol. 2004 Jul;182(1):123-32. abstract |
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Li G, Mobbs CV, Scarpace PJ. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes. 2003 Aug;52(8):1951-7. abstract |
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Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ. Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience. 2002;115(3):879-89. abstract |
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Lingyun Li, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1996 - December 2000 |
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Dissertation Title |
Studies of the anticancer effects of the vascular targeting agent combretastatin A-4 disodium phosphate (CA4DP) |
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Professional Positions |
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Education |
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Publications |
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Rojiani AM, Li L, Rise L, Siemann DW. Activity of the vascular targeting agent combretastatin A-4 disodium phosphate in a xenograft model of AIDS-associated Kaposi's sarcoma. Acta Oncol. 2002;41(1):98-105. abstract |
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Li L, Rojiani AM, Siemann DW. Preclinical evaluations of therapies combining the vascular targeting agent combretastatin A-4 disodium phosphate and conventional anticancer therapies in the treatment of Kaposi's sarcoma. Acta Oncol. 2002;41(1):91-7. abstract |
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Li L, Rojiani A, Siemann DW. Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: effects on radiation therapy. Int J Radiat Oncol Biol Phys. 1998 Nov 1;42(4):899-903. abstract |
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Michelle A. McGarry, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1997 - August 2001 |
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Dissertation Title |
Benzo(A) pyrene-mediated effects on cellular adhesion and signal transduction pathways in endometrial cancer |
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Professional Positions |
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| Resident, Dept. of Pediatrics, University of Chicago | ||
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Medical Student, University of Florida College of Medicine |
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Education |
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Publications |
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McGarry MA, Charles GD, Medrano T, Bubb MR, Grant MB, Campbell-Thompson M, Shiverick KT. Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell adhesion proteins in human uterine RL95-2 cells. Biochem Biophys Res Commun. 2002 May 31;294(1):101-7. abstract |
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Beverly L. Metcalfe, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
Defining the role of the angiotensin II type 2 receptor in cardiovascular disease |
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Professional Positions |
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Postdoctoral Associate, University of Florida College of Medicine, Dept. of Physiology & Functional Genomics |
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Education |
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Publications |
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Metcalfe BL, Huentelman MJ, Parilak LD, Taylor DG, Katovich MJ, Knot HJ, Sumners C, Raizada MK. Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer. Hypertension. 2004 Jun;43(6):1233-8. abstract |
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Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK. Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics. 2003 Feb 6;12(3):221-8. Epub 2002 Dec 10. abstract |
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Metcalfe BL, Sellers KW, Jeng MJ, Huentelman MJ, Katovich MJ, Raizada MK. Gene therapy for cardiovascular disorders: is there a future? Ann N Y Acad Sci. 2001 Dec;953:31-42. Review. abstract |
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Metcalfe BL, Raizada M, Katovich MJ. Genetic targeting of the renin-angiotensin system for long-term control of hypertension. Curr Hypertens Rep. 2002 Feb;4(1):25-31. Review. abstract |
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Hao Pan, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2001 - May 2006 |
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Dissertation Title |
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Professional Positions |
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Education |
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B.S., Biochemistry, Nanjing University (P.R. China) |
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Publications |
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Grant MB, Afzal A, Spoerri P, Pan H, Shaw LC, Mames RN. The role of growth factors in the pathogenesis of diabetic retinopathy. Expert Opin Investig Drugs. 2004 Oct;13(10):1275-93. abstract |
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Pan H, Nguyen NQ, Yoshida H, Bentzien F, Shaw LC, Rentier-Delrue F, Martial JA, Weiner R, Struman I, Grant MB. Molecular targeting of antiangiogenic factor 16K hPRL inhibits oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2413-9. abstract |
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Abstracts Presented at Meetings Through Graduate Studies |
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