Biochemistry & Molecular Biology

Immunology & Microbiology

Neuroscience

Genetics

Molecular Cell Biology

Physiology & Pharmacology

Amici

Beck

Browd

Carrigan

Chokas

Coleman

Dhillon

Ellis

Flanary

Fortun

Haire

Herlihy

James

Jezzini

Larkin

Larner

Martin

Peden

Presti

Rau

Rhinehart

Ringger

Rodrigues

Roux

Shepherd

Smith

Tester

Turner

Wildeboer

Zhang

Stephanie Amici, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Lucia Notterpek, Ph.D. 

Department

Neuroscience

Enrolled

August 2000 - May 2006

Dissertation Title

Peripheral Myelin Protein 22 (Pmp22) is in a Complex with Alpha6 Beta4 Integrin and the Absence of Pmp22 Affects Schwann Cell Adhesion and Migration

Professional Positions

Publications

Amici SA, Dunn WA Jr, Murphy AJ, Adams NC, Gale NW, Valenzuela DM, Yancopoulos GD, Notterpek L.  Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.  J Neurosci. 2006 Jan 25;26(4):1179-89. abstract

Fortun J, Go JC, Li J, Amici SA, Dunn WA Jr, Notterpek L. Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression.  Neurobiol Dis. 2006 Apr;22(1):153-64. abstract

Roux KJ, Amici SA, Fletcher BS, Notterpek L. Modulation of epithelial morphology, monolayer permeability, and cell migration by gas3/PMP22. Mol Biol Cell. 2005 Mar;16(3):1142-51.  abstract

Roux KJ, Amici SA, Notterpek L.  The temporospatial expression of peripheral myelin protein 22 at the developing blood-nerve and blood-brain barriers. J Comp Neurol. 2004 Jul 5;474(4):578-88.  abstract

Dinculescu A, McDowell JH, Amici SA, Dugger DR, Richards N, Hargrave PA, Smith WC.  Insertional mutagenesis and immunochemical analysis of visual arrestin interaction with rhodopsin.  J Biol Chem. 2002 Apr 5;277(14):11703-8. Epub 2002 Jan 24. abstract

Notterpek L, Roux KJ, Amici SA, Yazdanpour A, Rahner C, Fletcher BS. Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc Natl Acad Sci USA. 2001 Dec 4;98(25):14404-9.  abstract

Abstracts Presented at Meetings

Roux KJ, Amici SA, Notterpek L. Peripheral myelin protein 22 is a constituent of the BBB with a poteintial involvement in junctional permeability. Sixth Symposium: Signal Transduction in the Blood-Brain Barriers. Szeged, Hungary. September 18-21, 2003, L5 p. 13.

Roux KJ, Amici SA, Notterpek L. The localization of PMP22 at intercellular junctions of the developing blood-brain barrier. Program No. 448.1. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.

Dinculescu A, McDowell JH, Amici S, Dugger D, Richards N, Hargrave PA, Smith WC. An insertional mutagenesis and immunochemical analysis of visual arrestin interaction with rhodopsin. Invest. Ophthalmol. Vis. Sci. 2002 43: E-Abstract 1391.

Kem W, Michalski S, Wildeboer K, Amici S, Soti F. Hoplonemertine pyridyl alkaloids: Interactions with nicotinic receptors. 7th Symposium: Pan American Section of the International Society on Toxinology on Animal, Plant and Microbial Toxins, Charlottesville, VA. 2001 p. 17.

Honors & Awards

1996  Alpha Lambda Delta National Honor Society

1998  Golden Key National Honor Society

2000  Alumni Graduate Fellowship, UF College of Medicine

2003  Bryan W. Robinson Neurological Foundation Grant-in-Aid Achievement award (competitive)

2005  Silver Medal Finalist, Medical Guild Graduate Student Research Competition

2005  First Place, Neuroscience Advanced Concentration, Medical Guild Graduate Student Research Concentration

Ray D. Beck, Ph.D.

Advanced Concentration

Neuroscience

Mentor

John M. Petitto, M.D. 

Department

Neuroscience

Enrolled

August 1998 - August 2004

Dissertation Title

Alterations of septohippocampal structure in interleukin-2 knockout mice

Professional Positions

Publications

Beck RD Jr, King MA, Huang Z, Petitto JM. Alterations in septohippocampal cholinergic neurons resulting from interleukin-2 gene knockout. Brain Res. 2002 Nov 15;955(1-2):16-23.  abstract

Petitto JM, Huang Z, Lo J, Beck RD, Rinker C, Hartemink DA. Relationship between the development of autoimmunity and sensorimotor gating in MRL-lpr mice with reduced IL-2 production. Neurosci Lett. 2002 Aug 16;328(3):304-8.  abstract

Petitto JM, Huang Z, Hartemink DA, Beck R Jr. IL-2/15 receptor-beta gene deletion alters neurobehavioral performance. Brain Res. 2002 Mar 8;929(2):218-25.  abstract

Sara A. Berens, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Robert P. Yezierski, Ph.D. 

Department

Neuroscience

Enrolled 

August 2002 - August 2006

Dissertation Title

Professional Positions

Education

B.S., Chemistry, University of Florida

Publications

Berens SA, Colvin DC, Yu CG, Yezierski RP, Mareci TH.  Evaluation of the pathologic characteristics of excitotoxic spinal cord injury with MR imaging. AJNR Am J Neuroradiol. 2005 Aug;26(7):1612-22.  abstract

Abstracts Presented at Meetings

Samuel R. Browd, M.D., Ph.D.

Advanced Concentration

Neuroscience

Mentor

Christiana M. Leonard, Ph.D.

Department

Neuroscience

Enrolled

August 1998 - May 2000

Dissertation Title

Can imagined motor practice change cortical representations?

Professional Positions

Resident, University of Utah

Publications

Crosson B, Cato MA, Sadek JR, Gokcay D, Bauer RM, Fischler IS, Maron L, Gopinath K, Auerbach EJ, Browd SR, Briggs RW.  Semantic monitoring of words with emotional connotation during fMRI: contribution of anterior left frontal cortex. J Int Neuropsychol Soc. 2002 Jul;8(5):607-22.  abstract

Crosson B, Radonovich K, Sadek JR, Gokcay D, Bauer RM, Fischler IS, Cato MA, Maron L, Auerbach EJ, Browd SR, Briggs RW.  Left-hemisphere processing of emotional connotation during word generation. Neuroreport. 1999 Aug 20;10(12):2449-55.  abstract

Crosson B, Sadek JR, Bobholz JA, Gokcay D, Mohr CM, Leonard CM, Maron L, Auerbach EJ, Browd SR, Freeman AJ, Briggs RW.  Activity in the paracingulate and cingulate sulci during word generation: an fMRI study of functional anatomy. Cereb Cortex. 1999 Jun;9(4):307-16.  abstract

Helveston W, Gilmore R, Roper S, Mastin S, Quisling R, Drane W, Eikman E, Leonard C, Browd S, Childress D.  Intractable temporal lobe epilepsy: comparison of positron emission tomography with qualitative and quantitative MR. AJNR Am J Neuroradiol. 1996 Sep;17(8):1515-21.  abstract

Mastin ST, Drane WE, Gilmore RL, Helveston WR, Quisling RG, Roper SN, Eikman EA, Browd SR.  Prospective localization of epileptogenic foci: comparison of PET and SPECT with site of surgery and clinical outcome. Radiology. 1996 May;199(2):375-80.  abstract

Matthew A. Carrigan, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Steven A. Benner, Ph.D.

Department

Neuroscience;  Chemistry

Enrolled

August 1997 - December 2002

Dissertation Title

Searching molecular landscapes for the evolution of primal catalysts:  in vitro selection of DNA-based ribonucleases

Professional Positions

Postdoctoral Associate, Dept. Chemistry, University of Florida

Education

B.S., Biomedical Science, University of Florida

Publications

Ricardo A, Carrigan MA, Olcott AN, Benner SA.  Borate minerals stabilize ribose. Science. 2004 Jan 9;303(5655):196.  abstract

Honors & Awards

Environmental Category (2nd Place) 1989, Environmental Category (1991) 3rd Place

UF Grinter Graduate Student Honors Scholarship, 1997-2000

UF Neuroscience Department, Graduate Travel Grant Award, 1999

UF Undergraduate Research Symposium Excellence in Research - 1st Place, 1997

UF IFAS Science Scholarship Award, 1994, 1995, 1996

Barry Goldwater National Science Scholarship Award, 1995, 1996, 1997

Ann L. Chokas, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Harry S. Nick, Ph.D.

Department

Neuroscience

Enrolled

August 1999 - December 2004

Dissertation Title

Identification of trans-acting factors that mediate the manganese superoxide dismutase enhancer functions

Professional Positions

Education

Publications

Kuo S, Chokas AL, Rogers RJ, Nick HS. PIN*POINT analysis on the endogenous MnSOD promoter: specific demonstration of Sp1 binding in vivo. Am J Physiol Cell Physiol. 2003 Feb;284(2):C528-34.  abstract

Honors & Awards

Abstracts Presented at Meetings Through Graduate Studies

Jason E. Coleman, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Susan L. Semple-Rowland, Ph.D.

Department

Neuroscience

Enrolled

August 1998 - May 2003

Dissertation Title

Efficient transduction and targeted expression of lentiviral vector transgenes in the developing retina  Full text

Professional Positions

Postdoctoral Associate, Dept. of Neuroscience, UF College of Medicine

Postdoctoral Associate, Picower Center for Learning & Memory, Massachussetts Institute of Technology

Publications

Coleman JE, Zhang Y, Brown GA, Semple-Rowland SL. Related Articles, Links Cone Cell Survival and Downregulation of GCAP1 Protein in the Retinas of GC1 Knockout Mice. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3397-403.  abstract

Zhang Y, Coleman JE, Fuchs GE, Semple-Rowland SL.  Circadian oscillator function in embryonic retina and retinal explant cultures. Brain Res Mol Brain Res. 2003 May 26;114(1):9-19.  abstract

Coleman JE, Huentelman MJ, Kasparov S, Metcalfe BL, Paton JF, Katovich MJ, Semple-Rowland SL, Raizada MK.  Efficient large-scale production and concentration of HIV-1-based lentiviral vectors for use in vivo. Physiol Genomics. 2003 Feb 6;12(3):221-8.  abstract

Coleman JE, Fuchs GE, Semple-Rowland SL.  Analyses of the guanylate cyclase activating protein-1 gene promoter in the developing retina. Invest Ophthalmol Vis Sci. 2002 May;43(5):1335-43.  abstract

Semple-Rowland SL, Tepedino M, Coleman JE.  Pinopsin mRNA levels are significantly elevated in the pineal glands of chickens carrying a null mutation in guanylate cyclase-1. Brain Res Mol Brain Res. 2001 Dec 16;97(1):51-8.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Coleman JE, Chang L-J and Semple-Rowland SL (2001) Retrovirus- and lentivirus-mediated transgene expression in chicken retina: In vivo analyses. Invest. Ophthalmol. Vis. Sci. 1860, B110.

Coleman JE and Semple-Rowland SL (2001) Lentivirus-mediated analyses of the GCAP1 gene promoter in developing chicken retina. Fifth Annual Vision Research Conference on Animal Models of Retinal Degeneration, April 27-28, Fort Lauderdale, FL.

Semple-Rowland SL and Coleman JE (2000) Strategies for rescue of photoreceptor function in the GUCY1*B chicken model of Leber congenital amaurosis-type 1 (LCA-1). Invited seminar at XIV International Congress of Eye Research, Oct. 15-20, Santa Fe, New Mexico.

Coleman JE, Voisin V, and Semple-Rowland SL (2000) Analyses of the chicken guanylate cyclase activating protein-1 (GCAP1) promoter in primary chicken retinal and human WERI Rb-1 cultures. Inv. Ophthalmol. Vis. Sci. 41, S390.

Semple-Rowland SL, Coleman JE, Vaughn J, Larkin P, Nykamp K, Baehr W and Chang L-J (1999) Lentiviral vector-mediated gene therapy for rescue of the rd chicken. FASEB Conference on the Biology and Chemistry of Vision, June 13-18, Copper Mountain, CO.

Coleman JE, Jones HC, Paiva M (1997) Neurotrophic activity is altered in the striatum and hippocampus of the hydrocephalic H-Tx rat. Soc. Neurosci. Abstr. 23, 49.

Honors & Awards

1996 Bryan W. Robinson Neurological Foundation Neuroscience Grant in Aid

1996 University of Florida Medical Guild Minigrant

Graduate Fellowship for Outstanding Research, UF College of Medicine, 2002

Jessica Conde, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Wolfgang J. Streit, Ph.D.

Department

Neuroscience

Enrolled 

August 1999 - April 2005

Dissertation Title

Effects of aging on microglial activation in response to neuronal injury

Professional Positions

Student, UF College of Nursing MS Program

Education

B.S. Microbiology and Cell Science, University of Florida, 1999

Publications

Conde JR, Streit WJ.  Effect of Aging on the Microglial Response to Peripheral Nerve Injury.  Neurobiol Aging. (submitted)

Striet WJ, Conde JR, Fendrick SE, Flanary BE, Mariani CL.  Role of Microglia in the CNS Immune Response.  Neurol Res. (submitted)

Streit WJ, Conde JR, Fendrick SE, Flanary BE, Mariani CL.  Role of microglia in the central nervous system's immune response. Neurol Res. 2005 Oct;27(7):685-91. Review.  abstract

Streit WJ, Conde JR, Harrison JK. Chemokines and Alzheimer's disease. Neurobiol Aging. 2001 Nov-Dec;22(6):909-13.  abstract

Abstracts Presented at Meetings

Conde JR, Miller KR, Streit WJ.  Effect of aging on the proliferative response of microglia to facial nerve axotomy.  Program no. 450.7.  2004 Abstract Viewer/Itinerary Planner.  Society for Neuroscience, Washington, DC, 2004.  Online.

Conde JR, Streit WJ.  Effects of aging on microglial activation in response to neuronal injury.  University of Florida Graduate Student Council Forum, 2005.

Honors & Awards

2004 University of Florida Graduate Student Council Travel Award

2002 University of Florida Medical Guild Minigrant

2001 Bryan W. Robinson Neurological Foundation Grant-in-Aid Achievement award (competitive)

1999-2003 University of Florida Graduate Alumni Fellowship

Harveen Dhillon, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Pushpa S. Kalra, Ph.D.

Department

Physiology & Functional Genomics

Enrolled

August 1996 - December 2000

Dissertation Title

Effects of recombinant adeno-associated virus encoding leptin on body weight regulation and energy homeostasis   Full text

Professional Positions

Postdoctoral Associate in laboratory of Professor Bradford Lowell, Division of Endocrinology, Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, MA

Education

B.S., University of Arizona

Publications

Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB.  betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science. 2002 Aug 2;297(5582):843-5.  abstract

Beretta E, Dhillon H, Kalra PS, Kalra SP.  Central LIF gene therapy suppresses food intake, body weight, serum leptin and insulin for extended periods. Peptides. 2002 May;23(5):975-84.  abstract

Dube MG, Beretta E, Dhillon H, Ueno N, Kalra PS, Kalra SP.  Central leptin gene therapy blocks high-fat diet-induced weight gain, hyperleptinemia, and hyperinsulinemia: increase in serum ghrelin levels. Diabetes. 2002 Jun;51(6):1729-36.  abstract

Dhillon H, Kalra SP, Kalra PS.  Dose-dependent effects of central leptin gene therapy on genes that regulate body weight and appetite in the hypothalamus. Mol Ther. 2001 Aug;4(2):139-45.  abstract

Dhillon H, Kalra SP, Prima V, Zolotukhin S, Scarpace PJ, Moldawer LL, Muzyczka N, Kalra PS.  Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study. Regul Pept. 2001 Jun 15;99(2-3):69-77.  abstract

Dhillon H, Ge Y, Minter RM, Prima V, Moldawer LL, Muzyczka N, Zolotukhin S, Kalra PS, Kalra SP.  Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change. Regul Pept. 2000 Aug 25;92(1-3):97-105.  abstract

Pu S, Dhillon H, Moldawer LL, Kalra PS, Kalra SP.  Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor. J Neuroendocrinol. 2000 Sep;12(9):827-32.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Dhillon H, YL Ge, PJ Scarpace, V Prima, S Zolotukhin, SP Kalra and PS Kalra. Central leptin therapy reveals differential dose-dependent effects on body weight (bw) gain, energy intake and expenditure. Society for Neuroscience Abstract, 2000 (Oral Presentation).

Beretta E, V Prima, H Dhillon, L Moldawer, N Muzyczka, S Zolotukhin, P Kalra, S Kalra. Long-term Suppression of Weight Gain and Obesity by rAAV-LIF Therapy. Abstract submitted to the 3 rd Annual American Society for Gene Therapy Meeting, June 1-5, 2000.

Beretta E, M Dube, H Dhillon, V Prima, S Zolotukhin, N Muzyczka, PS Kalra and SP Kalra. Leptin Gene Therapy Reduces Food Intake and Body Weight Without Affecting Onset of Puberty and Reproductive Cycles. Submitted to the Society for the Study for Reproduction Annual Meeting, 2000.

Zolotukhin S, H Dhillon, E Beretta, V Prima, L Moldawer, PS Kalra, N Muzyczka and SP Kalra. Control of body weight in lean and obese rodent models using centrally delivered recombinant adeno-associated virus (rAAV) vectors encoding cytokines leptin, CNTF and LIF. Abstract submitted to the Keystone Symposia Feb 2000.

Activation of STAT-dependent signaling in rat hypothalamus by leptin, CNTF and LIF transgenes delivered centrally via recombinant adeno-associated (rAAV) vectors. Y Sautin, H Dhillon, E Beretta, V Prima, N Muzyczka, PS Kalra, SP Kalra. Abstract submitted to the Keystone Symposia Feb 2000.

Dhillon H, Dube MG, Kalra SP and Kalra PS. Site specific upregulation of NPY receptors in hyperphagic rats. Society for Neuroscience abstract 1998. Oral Presentation.

Dhillon H, RM Minter, D Topping, V Prima, LL Moldawer, N Muzyczka, PS Kalra, SP Kalra and S Zolotukhin. Long-term correction of obesity using centrally delivered rAAV encoding anorexigenic cytokines. Abstract submitted to the American Society for Gene Therapy Meeting, June 9-13 1999. Poster Presentation.

Dhillon H, S Zolotukhin, SP Kalra and PS Kalra. Sexual Dimorphism in the response to leptin gene therapy via a recombinant adeno-associated virus (rAAV) vector. 214.3 Society for Neuroscience Abstract, 1999. Oral Presentation.

Honors & Awards

University of Florida Medical Guild Research Award 2000

Department of Neuroscience Graduate Student Research Award, 2000

Outstanding International Student Award, UF College of Medicine, 2000

Bryan W Robinson Memorial Endowment for the Neuroscience's Grant 1999

Department of Neuroscience Graduate Student Research Award 1999

University of Florida medical guild research mini-grant 1998

Grinter Academic Merit Scholarship at the University of Florida 1996-1999

Cowden Academic Scholarship at the University of Arizona 1994-95

National Junior Research Fellowship awarded by the Government of India, 1992-1994

Rebecca C. Ellis, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Douglas K. Anderson, Ph.D.

Department

Neuroscience

Enrolled

August 1998 - December 2004

Dissertation Title

Characterization of cathepsin B mRNA and protein expression, enzymatic activity and cellular localization following contusion spinal cord injury in rats

Professional Positions

Education

Publications

Ellis RC, Earnhardt JN, Hayes RL, Wang KK, Anderson DK. Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats. J Neurochem. 2004 Feb;88(3):689-697.  abstract

Bitran D, Dugan M, Renda P, Ellis R, Foley M. Anxiolytic effects of the neuroactive steroid pregnanolone (3 alpha-OH-5 beta-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum. Brain Res. 1999 Dec 11;850(1-2):217-24.  abstract

Honors & Awards

Fine Scientific Tools Travel Award (2002)

Brain and Spinal Cord Injury Rehabilitation Trust Fund (2002)

ASN Young Investigator Education Enhancement Award (2002)

Brain and Spinal Cord Injury Rehabilitation Trust Fund (2001)

Department of Neuroscience Travel Award (2001)

University of Florida Graduate Student Council Travel Award (2001)

Brain and Spinal Cord Injury Rehabilitation Trust Fund (1999)

College of the Holy Cross Compton Gold Medal of Excellence in Science (1998)

Abstracts Presented at Meetings Through Graduate Studies

Bitran D, Klibansky D, Solano S, Dowd S, Ellis RC, and Renda P. Effects of pregnanolone microinjections in the amygdala on behaviors in three animal models of anxiety. Northeast Undergraduate Research on Neuroscience (N.E.U.R.O.N.), Hartford, CT, May 1, 1997.

Bitran D, Dugan M, Renda P, Solano S, Dowd S, Klibansky D, Ellis RC and Rausch E. Behavior in animal models of anxiety after intracranial microinjection of pregnanolone in hippocampus, lateral septum, and basolateral amydgala. Society for Neuroscience, New Orleans, LA, October 25-30, 1997.

Ellis RC, Bitran D. Picrotoxin blocks the anxiolytic effect of pregnanolone in hippocampus and in the lateral septum, but flumazenil, a central benzodiazepine receptor antagonist, and PK11195, a peripheral benzodiazepine receptor antagonist, do not. Northeast Undergraduate Research on Neuroscience (N.E.U.R.O.N.), Hartford, CT, May 3, 1998.

Bitran D, Ellis RC, and Foley M. Intrahippocampal injection of FGIN1-27, a mitochondrial benzodiazepine receptor (MBR) agonist, elicits does-dependent anxiolytic effects that are blocked by picrotoxin, a GABAA receptor-gated Cl- channel blocker, and are attenuated by PK11195, an MBR antagonist. Society for Neuroscience, Miami, FL, October 23-38, 1999.

Ellis RC, Earnhardt JN, Nick HS, Hayes RL, Tolentino PJ, O'Steen WA, Shaw G, Anderson DK. Changes in cathepsin B gene and protein expression following acute spinal cord injury. Society for Neuroscience, San Diego, CA. November 10-15, 2001.

Ellis RC, Earnhardt JN, Nick HS, Hayes RL, Anderson DK. Characterization of cathepsin B expression following contusion spinal cord injury (SCI). American Society for Neurochemistry, Palm Beach, FL, June 22-26, 2002.

Ellis RC, Earnhardt JN, Hayes RL, O'Steen WA, Anderson DK. Contusion Spinal Cord Injury (SCI) Induced Changes in Cathepsin B Gene and Protein Expression. National and International Neurotrauma Societies, Tampa, FL, October 27-November 1, 2002.

Sarah E. Fendrick, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Wolfgang J. Streit, Ph.D.

Department

Neuroscience

Enrolled 

August 2002 - August 2006

Dissertation Title

Professional Positions

Education

B.S., Genetics, University of Wisconsin

Publications

Streit WJ, Conde JR, Fendrick SE, Flanary BE, Mariani CL.  Role of microglia in the central nervous system's immune response. Neurol Res. 2005 Oct;27(7):685-91. Review.  abstract

Fendrick SE, Miller KR, Streit WJ.  Minocycline does not inhibit microglia proliferation or neuronal regeneration in the facial nucleus following crush injury. Neurosci Lett. 2005 Sep 16;385(3):220-3.  abstract

Barry Flanary, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Wolfgang J. Streit, Ph.D.

Department

Neuroscience

Enrolled 

August 2001 - April 2005

Dissertation Title

Analysis of Rat Microglial Cellular Senescence as Determined by Measurements of Telomere Length and Telomerase Activity

Education

B.S., Biological Sciences, Illinois State University

M.S., Biological Sciences, Illinois State University

Professional Positions 

Publications

Streit WJ, Conde JR, Fendrick SE, Flanary BE, Mariani CL.  Role of microglia in the central nervous system's immune response. Neurol Res. 2005 Oct;27(7):685-91. Review.  abstract

Flanary BE, Streit WJ. Progressive telomere shortening occurs in cultured rat microglia, but not astrocytes. Glia. 2004 Jan 1;45(1):75-88.  abstract

Flanary BE, Streit WJ.  Telomeres shorten with age in rat cerebellum and cortex in vivo. J Anti Aging Med. 2003;6(4):299-308.  abstract

Flanary B. Review of the gerontology literature. J Anti Aging Med. 2003 Spring;6(1):41-3.  abstract

Van Rhein SL, Flanary BE, Juliano SA. Effects of habitat type and drying on Ascogregarina barretti (Eugregarinida: Lecudinidae) infection in Aedes triseritatus (Diptera: Culicidae). J Med Entomol. 2000 Nov;37(6):950-6.  abstract

Jenny Fortun, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Lucia Notterpek, Ph.D.

Department

Neuroscience

Enrolled 

August 2000 - April 2005

Dissertation Title

Protein Aggregation In Peripheral Myelin Protein 22 (PMP22)-Associated Neuropathies

Education

B.S., Biochemistry

Professional Position  

Postdoctoral Fellow, University of Miami, Department of Neuroscience

Publications

Fortun J, Go JC, Li J, Amici SA, Dunn WA Jr, Notterpek L. Alterations in degradative pathways and protein aggregation in a neuropathy model based on PMP22 overexpression.  Neurobiol Dis. 2006 Apr;22(1):153-64. abstract

Fortun J, Li J, Go J, Fenstermaker A, Fletcher BS, Notterpek L.  Impaired proteasome activity and accumulation of ubiquitinated substrates in a hereditary neuropathy model. J Neurochem. 2005 Mar;92(6):1531-41. abstract

Fortun J, Dunn WA Jr, Joy S, Li J, Notterpek L. Emerging role for autophagy in the removal of aggresomes in Schwann cells. J Neurosci. 2003 Nov 19;23(33):10672-80.  abstract

Abstracts Presented at Meetings

Notterpek, L., Fortun, J. & Fergurson, T.A. (2002). Aggregation of peripheral myelin protein 22 in the Trembler J neuropathy nerves. Journal of Neurochemistry 81 (Suppl.1), p77.

Fortun, J. & Nottepek, L. (2003). Aggresomes are transient structures in Schwann cells. Journal of Neurochemistry 85 (suppl.1) p85.
Fortun J., Dunn, W.J., Joy S., & Notterpek, L. (2003). Emerging role for autophagy in the removal of aggresomes. Society for Neuroscience meeting, 2003.

Li J., Fortun J., & Notterpek, L. (2003) Impairment of the ubiquitin-proteasome pathway in Trembler J nerves. Society for Neuroscience meeting, 2003.

Honors & Awards

Alumni Graduate Fellowship, University of Florida

2003 Bryan W. Robinson Neurological Foundation Grant-in-Aid (competitive), Achievement award, Tallahassee, Florida

Shannon Haire,  Ph.D.

Advanced Concentration

Neuroscience

Mentor

Susan L. Semple-Rowland, Ph.D.

Department

Neuroscience

Enrolled

August 2001 - May 2006

Dissertation Title

Gene Therapy Restores Function to Cone Cells in an Animal Model of Leber Congenital Amaurosis (LCA-1)

Professional Positions  

Post-doctoral Fellow, University of Florida Dept of Ophthalmology, May 2006

Education

B.S., Marine Biology, Fairleigh Dickinson University, Edward Williams College

Publications

Pang J, Cheng M, Haire SE, Planelles V, Blanks JC.  Efficiency of lentiviral transduction during development in normal and rd mice.  2006.  Molecular Vision (in press)

Williams M, Coleman JE, Haire S, Aleman TS, Cideciyan AV, Jacobson SG , SL Semple-Rowland SL.  Lentiviral Vector Mediated Expression of GC1 Restores Vision in the GUCY1*B Avian Model of Leber Congenital Amaurosis (LCA).  2006.  PLOS (in press)

Abstracts Presented at Meetings Through Graduate Studies

Boye SL1, Peterson JJ1, Petrs-Silva H2, Min SH1, Pang JJ1, Haire SE3, Li Q1, Chiodo VA1, Ding M1, Hauswirth WW1.  Transduction and Tropism of an Abbreviated form of CMV-Chicken beta-actin Promoter (CBA) with AAV in Mouse Retina. Dept. Ophthalmology University of Florida, Gainesville, FL1; Instituto de Biofisica Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil2; Dept. Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL3 (ARVO, Ft. Lauderdale, FL 2006)

SL Semple-Rowland1, M Williams1, JE Coleman1, S Haire1, TS Aleman2, AV Cideciyan2, SG Jacobson2.  Lentiviral Vector Mediated Expression of GC1 Restores Vision in the GUCY1*B Avian Model of Leber Congenital Amaurosis (LCA). 1Dept. Neuroscience, University of Florida McKnight Brain Institute, Gainesville, FL and 2Dept. Ophthalmology, University of Pennsylvania, Philadelphia, PA (Ocular Cell & Molecular Biology. Sarasota, FL 2005)

Haire SE1, Pang J2, Robinson A1, Boye SL2, Sokal I3, Craft CM4, Palczewski K3, Hauswirth WW2, Semple-Rowland SL.  AAV-GC1 restores subcellular distribution of cone arrestin in the GC1 KO mouse.  Dept. Neuroscience, McKnight Brain Institute1, Dept. Opthalmology2 University of Florida, Gainesville, FL; Dept. Opthalmology3, University of Washington, Seattle, WA; Dept. Ophthalmology 4, USC Keck Med. Sch, Los Angeles, CA. Oral presentation at at Ocular Cell & Molecular Biology Meeting, Sarasota, FL, September 2005

S.E. Haire, I.A. Elder, D.R. Saban, J.J. Janssen, A.M. M. Timmers.  Optimization of Lentiviral Gene Delivery to the Retinal Pigment Epithelium in vivo. Dept. Ophthalmology, University of Florida, Gainesville, FL; Dept. Ophthalmology, University of Nijmegen, Nijmegen, Netherlands. (ARVO, Ft. Lauderdale, FL 2003)

A.M. Timmers, T.B. Nguyen, S.E. Haire, I.A. Elder, M.P. Popp.  CNTF Induced Gene Expression in Rat Retina. Dept. Ophthalmology, ICBR, University of Florida College of Medicine, Gainesville, FL (ARVO, Ft. Lauderdale, FL 2003)

Linser, P.J., J.D. Ochrietor, H.K. Lehman, A. Kohn, M. Dasher, S. Haire, and M.D.P. Corena.  Cellular Heterogeneity of the larval mosquito gut epithelium. [American Society for Cell Biology Abstract]. Molec. Biol. Cell 2000, 11 (supplement): 297a. Abstract 1546. (American Society for Cell Biology, San Fransisco, CA 2000)

John-David Herlihy, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Harry S. Nick, Ph.D.

Department

Neuroscience

Enrolled 

August 1999 - August 2006

Dissertation Title

Professional Positions

Education

B.S., Biology, University of Vermont

Publications

Muller C, Braag SA, Herlihy JD, Wasserfall CH, Chesrown SE, Nick HS, Atkinson MA, Flotte TR.  Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice.  Lab Invest. 2006 Feb;86(2):130-40. abstract

Virella-Lowell I, Herlihy JD, Liu B, Lopez C, Cruz P, Muller C, Baker HV, Flotte TR.  Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line. Mol Ther. 2004 Sep;10(3):562-73. abstract

Zhainazarov AB, Doolin R, Herlihy JD, Ache BW. Odor-stimulated phosphatidylinositol 3-kinase in lobster olfactory receptor cells. J Neurophysiol. 2001 Jun;85(6):2537-44.  abstract

G. Andrew James, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Yijun Liu, Ph.D.

Department

Neuroscience

Enrolled

August 2000 - December 2005

Dissertation Title

Modeling age-related learning deficits with functional neuroimaging connectivity analysis

Professional Positions  

Post-doctorial trainee, Emory University/Georgia Institute of Technology, Atlanta, GA

Education

B.S., Chemistry;  B.S., Psychology;  Georgia Institute of Technology

Publications

James GA, He G, Liu Y.  A full-size MRI-compatible keyboard response system. Neuroimage. 2005 Mar;25(1):328-31. Epub 2005 Jan 20. abstract

Shapira NA, Lessig MC, He AG, James GA, Driscoll DJ, Liu Y.  Satiety dysfunction in Prader-Willi syndrome demonstrated by fMRI. J Neurol Neurosurg Psychiatry. 2005 Feb;76(2):260-2. abstract

James GA, Gold MS, Liu Y. Interaction of satiety and reward response to food stimulation. J Addictive Dis. 2004; 23(3), 23-37.

Shapira NA, Liu Y, He AG, Bradley MM, Lessig MC, James GA, Stein DJ, Lang PJ, Goodman WK. Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry. 2003 Oct 1;54(7):751-6.  abstract

He AG, Tan LH, Tang Y, James GA, Wright P, Eckert MA, Fox PT, Liu Y. Modulation of neural connectivity during tongue movement and reading. Hum Brain Mapp. 2003 Mar;18(3):222-32.  abstract

James GA, Guo W, Liu Y. Imaging in vivo brain-hormone interaction in the control of eating and obesity. Diabetes Technol Ther. 2001 Winter;3(4):617-22.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Liu Y, Frost-Pineda K, James GA, Gold MS. Functional MRI Detection of Brain Changes Related to the Effectiveness of Novel Pharmacological Treatments for Obesity. Biol Psych. 55 (8S) 37S #128, 2004.

James, G.A., He, G., Tang, Y., & Liu, Y. (2004). Comparing patterns of implicit and explicit motor learning with a behavior driven functional connectivity analysis method. Presented at the 10th International conference on Functional Mapping of the Human Brain, June 13-17, 2004, Budapest, Hungary. Available on CD-Rom in Neuroimage, 22 (1).

James, G.A., Tang, Y., & Liu, Y. (2003). Comparing two serial response time implicit motor learning designs. Program No. 400.16. 2003 Abstracts Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003. CD-ROM.

James, G.A., Tang, Y., & Liu, Y. (2003). Brain activation by typing movement with an MRI-compatible keyboard [abstract]. Presented at the 9th International Conference on Functional Mapping of the Human Brain, June 19-22, 2003, New York, NY. Available on CD-Rom in Neuroimage, Vol 19, No. 2.

James, G.A., He, G., Eckert, M., & Liu, Y. (2003). An MRI-compatible keyboard recording system for functional investigation of complex motor behaviors. Eleventh Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine.

James, G.A., He, G., Miller, A.W., Taeb, Y. & Liu, Y. (2002). MRI of hunger and insula activation during a fasting paradigm. Tenth Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine.

James, G.A.; Leonard, C.M.; Maron, L.; Grudnik, J.; Eckert, M.A.; Mahoney, B.; Ricciuti, N.; DeBose, C.; Kuldau, J.M. Anatomical Risk Factors and Cognition in Schizophrenia. Soc. Neurosci. Abstr., Vol. 27, Program No. 572.14, 2001.

Honors & Awards

2005 Graduate Fellowship for Outstanding Research, UF College of Medicine

2003 ISMRM Educational Stipend for Students

2002 ISMRM Educational Stipend for Students

Sami Jezzini, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Leonid L. Moroz, Ph.D.

Department

Neuroscience

Enrolled

August 2000 - May 2006

Dissertation Title

Genomic approaches to neuronal identity:  Nitregic neurons and their targets in Aphysia californica

Professional Positions

Education 

A.A., Liberal Arts, Valencia Community College;  B.S., Neuroscience and Behavioral Biology, Emory University

Publications

Lovell P, Jezzini SH, Moroz LL.  Electroporation of neurons and growth cones in Aplysia californica. J Neurosci Methods. 2005 Sep 17 abstract

Sami H. Jezzini, Michaela Bodnarova, and Leonid L. Moroz. Two-Color In situ hybridization in the CNS of Aplysia californica. J Neuroscience Methods, In press

Timothy Drake, Sami Jezzini, Peter Lovell, Leonid L Moroz, and Weihong Tan. High-throughput Single Cell Glutamate Analysis: Aplysia Pleural Sensory Neurons. J Neuroscience Methods (2005), In press, available online Jan 2005.

Jezzini SH, Moroz LL.  Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica. Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):27-38. abstract

Jezzini SH, Hill AA, Kuzyk P, Calabrese RL. A detailed model of intersegmental coordination in the timing network of the leech heartbeat central pattern generator. J Neurophysiol. 2004 Feb;91(2):958-77.  abstract

Abstracts Presented at Meetings

S.H. Jezzini, M. Bodnarova, T. Ha, L.L. Moroz. Transmitter and electrophysiological mapping of synaptic connections in cerebro-buccal networks of Aplysia californica. Program No. 497.5. 2004 Abstract viewer/itinerary Planner. Washington, DC: Society for Neuroscience

S.H. Jezzini, J. Edwards, M. Bodnorova, Y. Panchin, E.R. Kandel, J. Ju, S. Kalachikov, L.L.Moroz. Microarray analysis of gene expression in single identified neurons of Aplysia californica. Program No. 92.23. 2003 Abstract viewer/itinerary Planner. Washington, DC: Society for Neuroscience

S.H. Jezzini, M. Bodnorova, P. Lovell and L.L Moroz. Modulation and distribution of K+ leak channels in molluscan neurons. Program No. 335.3. 2002 Abstract viewer/itinerary Planner. Washington, DC: Society for Neuroscience

S.H. Jezzini, A.A.V. Hill, and R.L. Calabrese. Dynamic activity of a coordinating fiber with two initiation sites. (2000) Society for Neuroscience Program No. 164.1.

Honors & Awards

UF Alumni Graduate Fellowship, 2000-2004

Erik A. Johnson, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Ronald L. Hayes, Ph.D. 

Department

Neuroscience

Enrolled

August 1999 - December 2004

Dissertation Title

Survivin Expression After Traumatic Brain Injury:  Potential Roles in Neuroprotection

Professional Positions

Education

Publications

Johnson EA, Svetlov SI, Pike BR, Tolentino PJ, Shaw G, Wang KK, Hayes RL, Pineda JA.  Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. J Neurotrauma. 2004 Sep;21(9):1183-95.  abstract

Fan T, Yang SH, Johnson E, Osteen B, Hayes R, Day AL, Simpkins JW. 17beta-Estradiol extends ischemic thresholds and exerts neuroprotective effects in cerebral subcortex against transient focal cerebral ischemia in rats. Brain Res. 2003 Dec 12;993(1-2):10-7.  abstract

Pike BR, Flint J, Dutta S, Johnson E, Wang KK, Hayes RL. Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats. J Neurochem. 2001 Sep;78(6):1297-306.  abstract

Honors & Awards

Abstracts Presented at Meetings Through Graduate Studies

Christopher D. King, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Robert P. Yezierski, Ph.D.

Department

Neuroscience

Enrolled 

August 2001- August 2006

Dissertation Title

Professional Positions

Education

B.S., Biology, Geneva College

Publications

Nakatsuka T, Chen M, Takeda D, King C, Ling J, Xing H, Ataka T, Vierck C, Yezierski R, Gu JG. Substance P-driven feed-forward inhibitory activity in the mammalian spinal cord. Mol Pain. 2005 Jun 29;1:20. abstract

King CD, Devine DP, Vierck CJ, Rodgers J, Yezierski RP. Differential effects of stress on escape and reflex responses to nociceptive thermal stimuli in the rat. Brain Res. 2003 Oct 17;987(2):214-22.  abstract

Caudle RM, Perez FM, King C, Yu CG, Yezierski RP. N-methyl-D-aspartate receptor subunit expression and phosphorylation following excitotoxic spinal cord injury in rats. Neurosci Lett. 2003 Sep 25;349(1):37-40.  abstract

Patrick M. Larkin, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Susan Semple-Rowland, Ph.D.

Department

Neuroscience

Enrolled

August 1996 - December 2000

Dissertation Title

The GUCY1*B chicken as a model for studying properties of light entrainment of photoreceptor circadian oscillators

Professional Positions

Postdoctoral Associate, Dept. Biochemistry & Molecular Biology, (Nancy Denslow, Ph.D.), UF College of Medicine, Gainesville, FL

Vice President for Research & Development, EcoArray, Alachua, FL

Publications

Larkin P, Sabo-Attwood T, Kelso J, Denslow ND.  Analysis of gene expression profiles in largemouth bass exposed to 17-beta-estradiol and to anthropogenic contaminants that behave as estrogens. Ecotoxicology. 2003 Dec;12(6):463-8.  abstract

Larkin P, Knoebl I, Denslow ND.  Differential gene expression analysis in fish exposed to endocrine disrupting compounds. Comp Biochem Physiol B Biochem Mol Biol. 2003 Oct;136(2):149-61.  abstract

Larkin P, Folmar LC, Hemmer MJ, Poston AJ, Denslow ND.  Expression profiling of estrogenic compounds using a sheepshead minnow cDNA macroarray. EHP Toxicogenomics. 2003 Jan;111(1T):29-36.  abstract

Larkin P, Sabo-Attwood T, Kelso J, Denslow ND.  Gene expression analysis of largemouth bass exposed to estradiol, nonylphenol, and p,p'-DDE. Comp Biochem Physiol B Biochem Mol Biol. 2002 Dec;133(4):543-57.  abstract

Larkin P, Folmar LC, Hemmer MJ, Poston AJ, Lee HS, Denslow ND.  Array technology as a tool to monitor exposure of fish to xenoestrogens. Mar Environ Res. 2002 Sep-Dec;54(3-5):395-9.  abstract

Larkin P, Semple-Rowland SL.  A null mutation in guanylate cyclase-1 alters the temporal dynamics and light entrainment properties of the iodopsin rhythm in cone photoreceptor cells. Brain Res Mol Brain Res. 2001 Aug 15;92(1-2):49-57.  abstract

Semple-Rowland SL, Larkin P, Bronson JD, Nykamp K, Streit WJ, Baehr W.  Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal. Mol Vis. 1999 Jul 28;5:14.  abstract

Larkin P, Baehr W, Semple-Rowland SL.  Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina. Brain Res Mol Brain Res. 1999 Jul 5;70(2):253-63.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Larkin P, and Semple-Rowland S L, The absence of phototransduction in GUCY1* photoreceptor cells disrupts the ability of the photoreceptor circadian oscillators to entrain to changes in the light cycle, Invest. Ophthalmol. Vis. Sci., (2000). Abstr. Nr 133 (poster presentation).

Semple-Rowland S L, Larkin P, and Tepedino M, A light transduction cascade involving Guanylate Cyclase-1 (GC1) regulates transcript levels of the light-driven pinopsin gene in chicken pineal, Invest. Ophthalmol. Vis. Sci., (2000). Abstr. Nr 134 (poster presentation).

Larkin P, Nykamp K, Baehr W, and Semple-Rowland S L, Analysis of the onset of GC1, GCAP1, PDEa', iodopsin, and rhodopsin gene expression in embryonic chicken retina, Invest. Ophthalmol. Vis. Sci., 40 (1999) S9393. Abstr. Nr 4957 (poster presentation).

Semple-Rowland S L, Coleman J E, Vaughn J, Larkin P, Nykamp, K., Baehr, W., and Chang, L-J., Lentiviral vector-mediated gene therapy for rescue of the rd chicken, FASEB conference on the Biology and Chemistry of Vision, (1999) Copper Mountain, CO.

Larkin P, Baehr W, and Semple-Rowland S L, Cloning and expression of the chicken clock gene in normal and rd/rd chicken retina, Invest. Ophthalmol. Vis. Sci., 39 (1998) S236. Abstr. Nr 1077 (oral presentation).

Semple-Rowland S L, Larkin P, Bronson D, and Baehr W, Characterization and analysis of the chicken GCAP1/GCAP2 genes and expression of GCAPs and GC1 in pineal gland, Invest. Ophthalmol. Vis. Sci., 39 (1998) S952. Abstr. Nr 4386 (poster presentation).

Honors & Awards

Medical Guild Graduate Research Competition Finalist, Neuroscience, 2000

Neurobiological Sciences Fellowship, 1999-2000

Golden Key National Honor Society Nominee, 1995, 1996

Stephen F. Larner, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Ronald L. Hayes, Ph.D.

Department

Neuroscience

Enrolled

August 1999 - August 2004

Dissertation Title

Up-regulation and activation of caspase-12 and caspase-7 following traumatic brain injury in rats

Professional Positions

Postdoctoral Associate, Dept. of Neuroscience, UF College of Medicine

Education

B.S., Biology, Seattle Pacific University

M.S., Neuroscience, University of Washington

Publications

Cousin SL, Luna VA, Larner S, and Roberts MC. Fluoroquinolone resistance mutations in Streptococcus pneumoniae's DNA gyrase and topoisomerase IV proteins selected by grepafloxacin. J Antimicrobial Chemotherapy. (Submitted)

Warren MW, Zheng W, Kobeissy FH, Cheng Liu M, Hayes RL, Gold MS, Larner SF, Wang KK.  Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure. Int J Neuropsychopharmacol. 2006 Aug 2;:1-11 [Epub ahead of print]  abstract

Larner SF, Hayes RL, McKinsey DM, Pike BR, Wang KK. Increased expression and processing of caspase-12 after traumatic brain injury in rats. J Neurochem. 2004 Jan;88(1):78-90.  abstract

Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J Cell Biol. 2000 Jul 24;150(2):335-47.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Larner SF, R.L. Hayes, D.M. McKinsey, B.R. Pike, and K.K.W. Wang. Increased expression and processing of caspase-12 after traumatic brain injury in rats. The 21st Annual National Neurotrauma Society Symposium and the Society for Neuroscience 33rd Annual Meeting (2003).

Larner SF, Pike BR, McKinsey DM, and Hayes RL. Effects of injury severity on regional and temporal caspase-12 mRNA and protein expression levels after traumatic brain injury in rats. First Joint Symposium of the National and International Neurotrauma Societies (2002).

N.C. Ringger, T.M Shepherd, E.A. Johnson, Larner SF, M.F. West, R.L. Hayes, and B.R. Pike (2001) Comparison of calpain and caspase-3 activation during necrosis, apoptosis, and endoplasmic reticulum stress. Society for Neuroscience 31st Annual Meeting (2001).

Honors & Awards

2000 Bryan W. Robinson Neurological Foundation Grant-in-Aid (competitive), Achievement award, Tallahassee, Florida

Fredric Manfredsson, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Ronald J. Mandel, Ph.D. 

Department

Neuroscience

Enrolled 

August 2001 - August 2006

Dissertation Title

Professional Positions

Education

B.S., Microbiology, Arizona State University

Publications

Mandel RJ, Manfredsson FP, Foust KD, Rising A, Reimsnider S, Nash K, Burger C.  Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Mol Ther. 2006 Mar;13(3):463-83.  abstract

Eugene Martin, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Purvis H. Bedenbaugh, III, Ph.D.

Department

Neuroscience

Enrolled 

August 1998 - April 2005

Dissertation Title

Lemniscal and Non-Lemniscal Responses to Ongoing Noises and Transient Probes in the Auditory Thalamus

Education

B.A., Biology & Psychology, Franklin & Marshall College

Publications

Martin EM, West MF, Bedenbaugh PH.  Masking and scrambling in the auditory thalamus of awake rats by Gaussian and modulated noises. Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14961-5.  abstract

Abstracts Presented at Meetings

Martin, E M, Cheung, S, Nagarajan S, Schreiner, C, Bedenbaugh, PB. Stimulus-reponse coherence for stretched and compressed vocalizations in squirrel monkey (Saimiri sciureus). Presented as a poster at the year 2000 Association for Research in Otolaryngology conference. Abstract# 301.

Carmen S. Peden, (M.D./Ph.D.)

Advanced Concentration

Neuroscience

Mentor

Ronald J. Mandel, Ph.D.

Department

Neuroscience

Enrolled

August 2000 - May 2004

Dissertation Title

Characterization of the immune response to recombinant adeno-associated viral vectors in the brain (abstract)

Professional Positions

Medical Student (M.D./Ph.D. program), UF College of Medicine

Education

Publications

Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N.  Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Mol Ther. 2004 Aug;10(2):302-17.  abstract

Peden CS, Burger C, Muzyczka N, Mandel RJ.  Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. J Virol. 2004 Jun;78(12):6344-59.  abstract

Matalon R, Surendran S, Rady PL, Quast MJ, Campbell GA, Matalon KM, Tyring SK, Wei J, Peden CS, Ezell EL, Muzyczka N, Mandel RJ.  Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease. Mol Ther. 2003 May;7(5 Pt 1):580-7.  abstract

Michael F. Presti, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Mark H. Lewis, Ph.D.

Department

Neuroscience

Enrolled

August 1998 - August 2004

Dissertation Title

Progress in identifying the neural substrates of abnormal repetitive behavior

Professional Positions

Medical Student, UF College of Medicine

Education

B.S., Behavioral Neurobiology, University of Florida

Publications

Presti MF, Watson CJ, Kennedy RT, Yang M, Lewis MH.  Behavior-related alterations of striatal neurochemistry in a mouse model of stereotyped movement disorder. Pharmacol Biochem Behav. 2004 Mar;77(3):501-7.  abstract

Presti MF, Gibney BC, Lewis MH. Effects of intrastriatal administration of selective dopaminergic ligands on spontaneous stereotypy in mice. Physiol Behav. 2004 Jan;80(4):433-9.  abstract

Presti MF, Mikes HM, Lewis MH. Selective blockade of spontaneous motor stereotypy via intrastriatal pharmacological manipulation. Pharmacol Biochem Behav. 2003 Mar;74(4):833-9.  abstract

Presti MF, Powell SB, Lewis MH. Dissociation between spontaneously emitted and apomorphine-induced stereotypy in Peromyscus maniculatus bairdii. Physiol Behav. 2002 Mar;75(3):347-53.  abstract

Turner CA, Presti MF, Newman HA, Bugenhagen P, Crnic L, Lewis MH. Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice. Behav Genet. 2001 Jul;31(4):393-400.  abstract

Kristofer Rau, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Richard D. Johnson, Ph.D. & Brian Y. Cooper, Ph.D.

Department

Neuroscience

Enrolled

August 1999 - May 2006

Dissertation Title

Characterization of sensory afferents innervating visceral tissue

Professional Positions

Faculty Associate - UF Dept of Oral & Maxillofacial Surgery and Diagnostic Sciences - Neuroscience Division, June 2006

Education

B.S., Microbiology, Auburn University

Publications

Jiang N, Rau KK, Johnson RD, Cooper BY.  Proton sensitivity Ca2+ permeability and molecular basis of Acid-sensing ion channels expressed in glabrous and hairy skin afferents. J Neurophysiol. 2006 Apr;95(4):2466-78.  abstract

Rau KK, Caudle RM, Cooper BY, Johnson RD.  Diverse immunocytochemical expression of opioid receptors in electrophysiologically defined cells of rat dorsal root ganglia. J Chem Neuroanat. 2005 Jun;29(4):255-64.  abstract

Rau KK, Johnson RD, Cooper BY.  Nicotinic AChR in subclassified capsaicin-sensitive and -insensitive nociceptors of the rat DRG. J Neurophysiol. 2005 Mar;93(3):1358-71.  abstract

Cooper BY, Johnson RD, Rau KK.  Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell. Neuroscience. 2004;129(1):209-24.  abstract

Hubscher CH, Petruska JC, Rau KK, Johnson RD. Co-expression of P2X receptor subunits on rat nodose neurons that bind the isolectin GS-I-B4. Neuroreport. 2001 Sep 17;12(13):2995-7.  abstract

Petruska JC, Cooper BY, Gu JG, Rau KK, Johnson RD. Distribution of P2X1, P2X2, and P2X3 receptor subunits in rat primary afferents: relation to population markers and specific cell types. J Chem Neuroanat. 2000 Nov;20(2):141-62.  abstract

Publications

Rau KK, Cooper BY, Johnson RD. Heat Reactivity and TRP Expression in Capsaicin Sensitive and Insensitive Subclassified Sensory Cells of the Rat DRG. SFN Abstracts (poster presentation), New Orleans (2003).

Rau KK, Cooper BY, Johnson RD, and Caudle RM. Differential Expression of Opioid Receptors in Subclassified Cells of Rat DRG. SFN Abstracts (poster presentation), Orlando (2002).

Rau KK, Cooper BY, and Johnson RD. Responses of sub-classified sacral DRG cells to capsaicin, pH, and ATP. SFN Abstracts (poster presentation), San Diego (2001).

Erin Keen Rhinehart, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Pushpa S. Kalra, Ph.D.

Department

Physiology & Functional Genomics

Enrolled

August 1998 - August 2003

Dissertation Title

Professional Positions

Postodoctoral Associate, Georgia State University, Atlanta, GA

Education

B.S., Behavioral Neuroscience, Lehigh University, Bethlehem, PA

Publications

German I, Roper MG, Kalra SP, Rhinehart E, Kennedy RT.  Capillary liquid chromatography of multiple peptides with on-line capillary electrophoresis immunoassay detection. Electrophoresis. 2001 Oct;22(17):3659-67.  abstract

N. Clair Ringger, D.V.M., Ph.D.

Advanced Concentration

Neuroscience

Mentor

Ronald L. Hayes, Ph.D

Department

Neuroscience

Enrolled

August 1998 - August 2004

Dissertation Title

A novel biomarker for traumatic brain injury: CSF II-spectrin breakdown product levels

Professional Positions

Clinical Instructor, Large Animal Internal Medicine, Atlantic Veterinary School, University of Prince Edward Island, Canada

Education

B.A., Rhodes College

M.S., Southern Illinois University

D.V.M., University of Georgia

Internal Medicine Residency, University of Florida College of Veterinary Medicine

Publications

Ringger NC, O'Steen B, Brabham JG, Silver X, Pineda J, Wang KKW, Hayes RL. A novel marker of traumatic brain injury: CSF aII-spectrin breakdown product levels are associated with injury magnitude and lesion size. J Neurotrauma  (Accepted for publication)

Ringger NC, Tolentino PJ, McKinsey DM, Pike BR, Wang KK, Hayes RL.  Effects of injury severity on regional and temporal mRNA expression levels of calpains and caspases after traumatic brain injury in rats. J Neurotrauma. 2004 Jul;21(7):829-41.  abstract

Zhao X, Bausano B, Pike BR, Newcomb-Fernandez JK, Wang KK, Shohami E, Ringger NC, DeFord SM, Anderson DK, Hayes RL. TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures. J Neurosci Res. 2001 Apr 15;64(2):121-31.  abstract

Ringger NC, Brown MP, Kohlepp SJ, Gronwall RR, Merritt K. Pharmacokinetics of ceftriaxone in neonatal foals. Equine Vet J. 1998 Mar;30(2):163-5.  abstract

Ringger NC, Edens L, Bain P, Raskin RE, Larock R. Acute myelogenous leukaemia in a mare. Aust Vet J. 1997 May;75(5):329-31.  abstract

Ringger NC, Lester GD, Neuwirth L, Merritt AM, Vetro T, Harrison J. Effect of bethanechol or erythromycin on gastric emptying in horses. Am J Vet Res. 1996 Dec;57(12):1771-5.  abstract

Ringger NC, Pearson EG, Gronwall R, Kohlepp SJ. Pharmacokinetics of ceftriaxone in healthy horses. Equine Vet J. 1996 Nov;28(6):476-9.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Ringger NC, O'Steen BE, Silver X, Wang KKW, Hayes RL. Comparison of biomarkers aII-spectrin, breakdown products, S100ß, and tau after traumatic brain injury. Journal of Neurotrauma Abstracts, (2003) October 20(10):1072.  Poster presented at the 21st Annual National Neurotrauma Society Symposium, Biloxi, MS.

Ringger NC, Silver X, O'Steen B, Brabham JG, DeFord SM, Pike BR, Hayes RL. CSF accumulation of calpain-specific aII-spectrin breakdown products are associated with injury magnitude and lesion volume after traumatic brain injury in rats. Journal of Neurotrauma Abstracts, (2002) October 19(10):1302.  Poster presented at the 20th Annual National Neurotrauma Society Symposium and The Sixth International Neurotrauma Symposium, Tampa, FL.

Ringger NC, Shepherd TM, Johnson EA, Larner SF, West MF, Hayes RL, Pike BR. Comparison of calpain and caspase-3 activation during necrosis, apoptosis, and endoplasmic reticulum stress. Society for Neuroscience Abstracts, (2001) November 27(1):566.  Poster presented at the Society for Neuroscience 31st Annual Meeting, San Diego, CA.

Ringger NC, Lester GD, Neuwirth L, Merritt AM, Vetro T, Harrison J. The effect of bethanechol or erythromycin on equine gastric emptying. ACVIM Forum, San Antonio, TX, May 1996.

Honors & Awards

B.W. Robinson Research Award, Tallahassee Memorial Hospital Foundation, 2003.

Anthony Rodrigues, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Andre Mauderli, Ph.D.

Department

Prosthodontics;  Neuroscience

Enrolled 

August 2000 - August 2005

Dissertation Title

Characteristics of somatic pain sensitizarion in irritable bowel syndrome (PDF)

Professional Positions

Education

B.A., Biology, Assumption College

Publications

Rodrigues AC, Nicholas Verne G, Schmidt S, Mauderli AP.  Hypersensitivity to cutaneous thermal nociceptive stimuli in irritable bowel syndrome. Pain. 2005 May;115(1-2):5-11.  abstract

Mauderli AP, Vierck CJ Jr, Cannon RL, Rodrigues A, Shen C. Relationships between skin temperature and temporal summation of heat and cold pain. J Neurophysiol. 2003 Jul;90(1):100-9.  abstract

Abstracts Presented at Meetings

Honors & Awards

pre-doctoral fellowship from National Institute of Neurological Disorders and Stroke.

Edgardo Rodriguez, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Ronald J. Mandel, Ph.D.

Department

Neuroscience

Enrolled 

August 1999 - August 2005

Dissertation Title

Characterization of the effects of reduced mutant huntingtin in the r6/1 model of huntington's disease  (PDF)

Education

B.S., Biology, University of Central Florida

Honors & Awards

Pre-doctoral Fellowship, National Institute of Neurological Disorders and Stroke

Kyle J. Roux, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Lucia Notterpek, Ph.D.

Department

Neuroscience

Enrolled

August 1999 - August 2004

Dissertation Title

Peripheral myelin protein 22 is a novel constituent of intercellular junctions  (PDF)

Professional Positions

Postdoctoral Associate, Dept.of Anatomy & Cell Biology, UF College of Medicine

Education

B.S., Biological Anthropology & Human Biology, Emory University

Publications

Johnson JS, Roux KJ, Fletcher BS, Fortun J, Notterpek L.  Molecular alterations resulting from frameshift mutations in peripheral myelin protein 22: implications for neuropathy severity. J Neurosci Res. 2005 Dec 15;82(6):743-52.  abstract

Roux KJ, Amici SA, Fletcher BS, Notterpek L.  Modulation of epithelial morphology, monolayer permeability, and cell migration by growth arrest specific 3/peripheral myelin protein 22. Mol Biol Cell. 2005 Mar;16(3):1142-51.  abstract

Roux KJ, Amici SA, Notterpek L.  The temporospatial expression of peripheral myelin protein 22 at the developing blood-nerve and blood-brain barriers. J Comp Neurol. 2004 Jul 5;474(4):578-88.  abstract

Notterpek L, Roux KJ, Amici SA, Yazdanpour A, Rahner C, Fletcher BS. Peripheral myelin protein 22 is a constituent of intercellular junctions in epithelia. Proc Natl Acad Sci USA. 2001 Dec 4;98(25):14404-9.  abstract

Rasmussen SA, Overman J, Thomson SA, Colman SD, Abernathy CR, Trimpert RE, Moose R, Virdi G, Roux K, Bauer M, Rojiani AM, Maria BL, Muir D, Wallace MR.  Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. Genes Chromosomes Cancer. 2000 Aug;28(4):425-31.  abstract

Zhang J, Kumar A, Roux K, Williams CA, Wallace MR. Elastin region deletions in Williams syndrome. Genet Test. 1999;3(4):357-9.  abstract

Messiaen LM, Callens T, Roux KJ, Mortier GR, De Paepe A, Abramowicz M, Pericak-Vance MA, Vance JM, Wallace MR. Exon 10b of the NF1 gene represents a mutational hotspot and harbors a recurrent missense mutation Y489C associated with aberrant splicing. Genet Med. 1999 Sep-Oct;1(6):248-53.  abstract

Honors & Awards

UF Alumni Fellowship, 1999-2003

Timothy M. Shepherd, M.D., Ph.D.

Advanced Concentration

Neuroscience

Mentor

Stephen J. Blackband, Ph.D.

Department

Neuroscience

Enrolled

August 1998 - August 2003

Dissertation Title

Diffusion magnetic resonance imaging in a rat hippocampal slice model of acute brain injury

Professional Positions

Medical Student, UF College of Medicine

Education

B.S., Biochemistry, Florida State University, Tallahassee, FL

Publications

Shepherd TM, Thelwall PE, Blackband SJ, Pike BR, Hayes RL, Wirth ED 3rd.  Diffusion magnetic resonance imaging study of a rat hippocampal slice model for acute brain injury. J Cereb Blood Flow Metab. 2003 Dec;23(12):1461-70.  abstract

Shepherd TM, Wirth ED 3rd, Thelwall PE, Chen HX, Roper SN, Blackband SJ.  Water diffusion measurements in perfused human hippocampal slices undergoing tonicity changes. Magn Reson Med. 2003 May;49(5):856-63.  abstract

Shepherd TM, Blackband SJ, Wirth ED 3rd.  Simultaneous diffusion MRI measurements from multiple perfused rat hippocampal slices. Magn Reson Med. 2002 Sep;48(3):565-9.  abstract

Honors & Awards

2002 ISMRM Student Travel Stipend

2001 Murray Goldstein Student Poster Competition Award (Neurotrauma Symposium)

2001 Neurotrama Student Travel Award

1998 American Heart Association Medical Student Research Fellowship

1995 Phi Beta Kappa

1994 Golden Key Honor Society

1993 Departmental Chemistry Award

1993 National Foundation for the Advancement of the Arts (NFAA) Writing Award

James L. Smith, Ph.D., M.B.A.

Advanced Concentration

Neuroscience

Mentor

Arthur S. Edison, Ph.D.

Department

Biochemistry & Molecular Biology

Enrolled

August 1986 - August 2002

Dissertation Title

Structural and functional characterization of the lantibiotic mutacin 1140   Full text

Professional Positions

Now working in a biotechnology company at the University of Florida Biotechnology Incubator, Alachua, Florida

Education

B.S., Biological Sciences, Secondary Math & Science Teaching, Florida State University, Tallahassee, FL

Publications

Smith L, Zachariah C, Thirumoorthy R, Rocca J, Novak J, Hillman JD, Edison AS.  Structure and dynamics of the lantibiotic mutacin 1140. Biochemistry. 2003 Sep 9;42(35):10372-84.  abstract

Green T, Perry K, Smith L, Phylip LH, Logan TM, Hagen SJ, Dunn BM, Edison A.  Ia 3, a yeast proteinase a inhibitor, is intrinsically unstructured in solution. Scientific World Journal. 2002 Jan 2;2(1 Suppl 2):99-101.  abstract

Smith L, Novak J, Rocca J, McClung S, Hillman JD, Edison AS.  Covalent structure of mutacin 1140 and a novel method for the rapid identification of lantibiotics. Eur J Biochem. 2000 Dec;267(23):6810-6.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Smith L, Hillman J D, Rocca J, and Edison A S. "Covalent and Initial Three-Dimensional Structure of the Lantibiotic Mutacin 1140" South East Magnetic Resonance Conference, Tallahassee, Florida, p49-102, (1999).

Smith L, Hillman J D, Novak J, Segura E, Rocca J, and Edison A S. "Probing Structural Heterogeneity in Mutacin 1140, a Novel Lantibiotic" 40th International Experimental Nuclear Magnetic Resonance Conference, Orlando, Florida, p034-73, (1999).

Green T, Smith L, Edison A S, Perry K, Zachariah C, Phylip L, Kay J, and Dunn B M. "Structure-Function Studies of IA3, A Potent Inhibitor of Yeast Proteinase A" 2nd International Conference on Proteinase Inhibitors, Gainesville, Florida, (1999).

Green T, Smith L, Edison A S, Perry K, Zachariah C, Phylip L, Kay J, and Dunn M. "Structure-Function Studies of IA3, A Potent Inhibitor of Yeast Proteinase A" 8th International Aspartic Proteinase Conference, Funchal, Maderia, Portugal, (1999).

Evans J H, and Smith L. "Strontium can be Substituted for Calcium in the Chlamydomonas reinhardtii Flagellar Regeneration System" Mol. Biol. Cell 5:35a, (1994).

Nicole Tester, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Dena R. Howland, Ph.D.

Department

Neuroscience

Enrolled

August 1999 - May 2006

Dissertation Title

Use of chondroitinase ABC following spinal cord injury in the adult cat:  Enzyme thermostability and the effects of CS-GAG degradation on locomotor recovery

Professional Positions

Publications

Vierck CJ, Acosta-Rua A, Nelligan R, Tester N, Mauderli A. Low dose systemic morphine attenuates operant escape but facilitates innate reflex responses to thermal stimulation. J Pain. 2002 Aug;3(4):309-19.  abstract

Abstracts Presented at Meetings Through Graduate Studies

N.J. Tester and M. H. Rowe (1999) Summation of retinal signals in visual cortical receptive fields. The 217th American Chemical Society National Meeting, Abstr. Nr. 434 (Poster Presentation). 

N.J. Tester, T. Mareci, D.K. Anderson, and D.R. Howland (2001) Locomotor recovery following spinal cord compression in the adult cat. SouthEast Nerve Net Meeting, (Poster Presentation). 

N.J. Tester, S.A. Germain, T.H. Mareci, and D.R. Howland (2001) Recovery of specific locomotor characteristics in cats with spinal compressions. Society for Neuroscience, (Poster Presentation). 

N.J. Tester, A.H. Plaas, and D.R. Howland (2002) Chondroitin sulfate glycosaminoglycan composition in the developing, mature, and injured rat spinal cord. Society for Neuroscience, (Poster Presentation). 

N.J. Tester, E.W. Neeley, A.H. Plaas, and D.R. Howland (2003) Can chondroitinase treatment stop the GAG order on growth? SouthEast Nerve Net Meeting, (Poster Presentation). 

N.J. Tester, A.H. Plaas, and D.R. Howland (2003) The effects of chondroitinase ABC in spinal cord injured cats. National Neurotrauma Society Symposium, (Poster Presentation). 

N.J. Tester, A.H. Plaas, and D.R. Howland (2003) Chondroitin sulfate glycosaminoglycans and the effects of chondroiitnase ABC on behavioral and anatomical recovery following spinal cord injury in the adult cat. Society for Neuroscience, (Poster Presentation). 

N.J. Tester, A.H. Plaas, and D.R. Howland (2004) Motor recovery following chondroitinase ABC application to the acutely injured cat spinal cord. Society for Neuroscience, (Abstract Submitted, Poster Presentation).

Honors & Awards

American Chemical Society Award in Analytical Chemistry, 1998 

Scovill Award at Millikin University, 1998 

Women Chemists' Travel Award (ACS National Meeting), 1999 

AccuScan Travel Fellowship, Honorable Mention, 2001 

SouthEast Nerve Net Poster Award for Excellence, 2003 

National Neurotrauma Society Travel Grant supported by the National Institutes of Health (NIH), 2003 

Pre-Doctoral Fellowship (supported by NIH) in Neuromuscular Plasticity in Rehabilitation, 2003-2004

Cortney A. Turner, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Mark H. Lewis, Ph.D.

Department

Neuroscience;  Psychiatry

Enrolled

August 1998 - May 2003

Dissertation Title

Prevention of stereotyped behavior by environmental enrichment:  neurobiological mechanisms

Professional Positions

Postdoctoral Associate, Univ. Michigan, Ann Arbor, MI

Education

B.S., Neuroscience, Bowling Green State University, Firelands College, OH

Publications

Turner CA, Lewis MH.  Environmental enrichment: effects on stereotyped behavior and neurotrophin levels. Physiol Behav. 2003 Nov;80(2-3):259-66.  abstract

Turner CA, Lewis MH, King MA.  Environmental enrichment: effects on stereotyped behavior and dendritic morphology. Dev Psychobiol. 2003 Jul;43(1):20-7.  abstract

Panksepp J, Burgdorf J, Turner C, Gordon N.  Modeling ADHD-type arousal with unilateral frontal cortex damage in rats and beneficial effects of play therapy. Brain Cogn. 2003 Jun;52(1):97-105.  abstract

Turner CA, Yang MC, Lewis MH.  Environmental enrichment: effects on stereotyped behavior and regional neuronal metabolic activity. Brain Res. 2002 May 31;938(1-2):15-21.  abstract

Turner CA, Presti MF, Newman HA, Bugenhagen P, Crnic L, Lewis MH.  Spontaneous stereotypy in an animal model of Down syndrome: Ts65Dn mice. Behav Genet. 2001 Jul;31(4):393-400.  abstract

Turner C, Panksepp J, Bekkedal M, Borkowski C, Burgdorf J.  Paradoxical effects of serotonin and opioids in pemoline-induced self-injurious behavior. Pharmacol Biochem Behav. 1999 Jul;63(3):361-6.  abstract

Turner CA, Cooper S, Pulakat L.  Role of the His273 located in the sixth transmembrane domain of the angiotensin II receptor subtype AT2 in ligand-receptor interaction. Biochem Biophys Res Commun. 1999 Apr 21;257(3):704-7.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Panksepp J, Burgdorf J, Turner C, and Walter M. A new animal model for ADHD: unilateral frontal lobe damage in neonatal rats. 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA. 23(1):571 (1997)

Burgdorf J, Walter M, Turner C, Borkowski, M, Bekkedal M, Secor A, Hennessey M and Panksepp J. Developmental effects of central oxytocin on the neonatal rat. 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA. 23(1):1845 (1997)

Gordon N, Panksepp J, Secor A, Burgdorf J, Turner C, and Bingman V. Peripherally administered kainic acid induced brain damage effects on social and non social behaviors. 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA. (1998)

Turner C, Cooper S, Gavini N and Pulakat L. Studies on the role of His273 in the agonist binding and activation of rat angiotensin II receptor subtype AT2. The Ohio Journal of Science 98(1):A-43 (1998)

Lewis M, Powell S, Turner C, Newman P, Bugenhagen P, Gendreau P and Crnic L. Spontaneous stereotypy in an animal model of Down syndrome (TS65DN mice). 29th Annual Meeting of the Society for Neuroscience, Miami, FL. (1999)

Lewis M, Powell S, Turner C, Presti M, Newman H, Bugenhagen P. Spontaneous stereotypy in an animal model of Down syndrome (Ts65Dn mice) 30th Annual Meeting of Behavioral Genetics, Int'l Ts65Dn Symposium, VT. (2000)

Panksepp J, Burgdorf J, Turner C, and Walter M. A new animal model for ADHD: unilateral frontal lobe damage in neonatal rats. 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA. 23(1):571 (1997)

Burgdorf J, Walter M, Turner C, Borkowski, M, Bekkedal M, Secor A, Hennessey M and Panksepp J. Developmental effects of central oxytocin on the neonatal rat. 27th Annual Meeting of the Society for Neuroscience, New Orleans, LA. 23(1):1845 (1997)

Gordon N, Panksepp J, Secor A, Burgdorf J, Turner C, and Bingman V. Peripherally administered kainic acid induced brain damage effects on social and non social behaviors. 28th Annual Meeting of the Society for Neuroscience, Los Angeles, CA. (1998)

Turner C, Cooper S, Gavini N and Pulakat L. Studies on the role of His273 in the agonist binding and activation of rat angiotensin II receptor subtype AT2. The Ohio Journal of Science 98(1):A-43 (1998)

Lewis M, Powell S, Turner C, Newman P, Bugenhagen P, Gendreau P and Crnic L. Spontaneous stereotypy in an animal model of Down syndrome (TS65DN mice). 29th Annual Meeting of the Society for Neuroscience, Miami, FL. (1999)

Lewis M, Powell S, Turner C, Presti M, Newman H, Bugenhagen P. Spontaneous stereotypy in an animal model of Down syndrome (Ts65Dn mice) 30th Annual Meeting of Behavioral Genetics, Int'l Ts65Dn Symposium, VT. (2000)

David C. Wang, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Floyd J. Thompson, Ph.D.

Department

Neuroscience;  Physiological Sciences

Enrolled

 August 1998 - May 2002

Dissertation Title

Quantitative study of intrathecal baclofen therapy (ITB) upon velocity dependent stretch reflexes and rate modulation of spinal reflexes

Professional Positions

Postdoctoral Associate, Dept. Neuroscience (Dena Howland, Ph.D.), UF, Gainesville, FL, Sept. 2002 - Aug. 2003

Medical Student, University of Miami Medical School, Fall 2003 - present

Publications

Wang DC, Bose P, Parmer R, Thompson FJ.  Chronic intrathecal baclofen treatment and withdrawal:  I. Changes in ankle torque and hind limb posture in normal rats. J Neurotrauma. 2002 Jul;19(7):875-86.  abstract

Thompson FJ, Parmer R, Reier PJ, Wang DC, Bose P.  Scientific basis of spasticity:  insights from a laboratory model. J Child Neurol. 2001 Jan;16(1):2-9.  abstract

Juzwin SJ, Wang DC, Anderson NJ, Wong FA.  The determination of RWJ-38705 (tramadol N-oxide) and its metabolites in preclinical pharmacokinetic studies using LC-MS/MS. J Pharm Biomed Anal. 2000 Apr;22(3):469-80.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Wang DC, Bose P, Wiley RG, Thompson FJ. Monoamine Modulation of Spinal Reflex Excitability: I.T. Infusion of anti-DBH Saporin- Timecourse for Neurophysiology. SFN abstracts, San Diego 2001.

Bose P, Wang DC, Parmer R, Wiley RG, Thompson FJ. Monoamine Modulation of Reflex Excitability: IT Infusion of anti-DBH Saporin- Timecourse for Behavior. SFN abstracts, San Diego 2001.

Thompson FJ, Wang DC, Parmer R, Bose P. Investigation of Intrathecal Baclofen Treatment (ITB) in a rat model of velocity dependent spasticity. SFN Abstracts, San Diego 2001.

Wang DC, Bose P, Parmer R, Thompson FJ. Chronic Treatment and Withdrawal of Intrathecal Baclofen Treatment: Changes in Ankle Torque and Gait in Normal Rats. SFN Abstracts, New Orleans 2000.

Matthew W. Warren (M.D., Ph.D. in 2008)

Advanced Concentration

Neuroscience

Mentor

Mark S. Gold, M.D.

Department

Psychiatry

Enrolled 

August 2001 - August 2006 (PhD program)

Dissertation Title

Professional Positions

UF Medical Student

Education

B.S., Biochemistry and Statistics, University of North Carolina at Chapel Hill

Publications

Warren MW, Zheng W, Kobeissy FH, Cheng Liu M, Hayes RL, Gold MS, Larner SF, Wang KK.  Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure. Int J Neuropsychopharmacol. 2006 Aug 2;:1-11 [Epub ahead of print]  abstract

Warren MW, Kobeissy FH, Liu MC, Hayes RL, Gold MS, Wang KK. Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury. Life Sci. 2005 Dec 5;78(3):301-9. Epub 2005 Aug 25.  abstract

Warren M, Frost-Pineda K, Gold M.  Body mass index and marijuana use.  J. Addict. Disease.  2005: 24(3):  95-100.

Gold M, Melker R, Frost-Pineda K, Morey T, Warren M, Dunn D.  Second-hand Exposure to Propofol and Fentanyl in the Operating Room:  Anesthesiologists; Occupational Opiate Addiction.  Quoted in Science:  "Anesthesia's Addiction Problem", by John Travis.  2004 306 (Nov 12):  1126-1127.  

Fuehrlein BS, Rutenberg MS, Silver JN, Warren MW, Theriaque DW, Duncan GE, Stacpoole PW, Brantly ML.  Differential metabolic effects of saturated versus polyunsaturated fats in ketogenic diets. J Clin Endocrinol Metab. 2004 Apr;89(4):1641-5.  abstract

Martin C, Warren M, Gold MS.  Methamphetamine.  Law Enforce. Exec. Forum.  2003; 3(5):  59-170.  

Vaisman A, Warren MW, Chaney SG. The effect of DNA structure on the catalytic efficiency and fidelity of human DNA polymerase beta on templates with platinum-DNA adducts. J Biol Chem. 2001 Jun 1;276(22):18999-9005.  abstract

Abstracts Presented at Meetings

American Associate for Addiction Psychiatry (Scottsdale, AZ, December 2005)

Society for Neuroscience (Washington, DC, November 2005)

American Society of Addiction Medicine (Dallas, TX, April 2005)

Guze Symposium on Alcoholism Comorbidity (St. Louis, MO, Feburary 2005)

American Society of Anesthesiologists (Las Vegas, NV, October 2004)

Society for Neuroscience (San Diego, CA, October 2004)

Society for Ingestive Behavior (Cincinati, OH, July 2004)

National MD/PhD Student Conference (Keystone, CO, July 2004)

College on Problems of Drug Dependence (San Juan, PR, June 2004)

Academy of Psychosomatic Medicine (San Diego, CA, November 2003)

Society for Neuroscience (New Orleans, LA, October 2003)

Clinical Research (Baltimore, MD, March 2003)

Honors & Awards

American Association of Addiction Psychiatry Travel Award, 2005

American Society of Addiction Medicine Young Investigator Award, 2005

Guze Symposium on Alcoholism Comorbidity Travel Award, 2005

University of Florida Alumni Fellow, 2003

Emmitt Rand Scholarship for the top UNC pre-medical undergraduate studying Chemistry, 2001

National Starch and Chemical Company Scholarship for Excellence in Undergraduate Research, 1999

Phi Beta Kappa, Fall 1999

Kristin Wildeboer, Ph.D.

Advanced Concentration

Neuroscience

Mentor

William R. Kem, Ph.D. 

Department

Neuroscience

Enrolled

August 2000 - December 2005

Dissertation Title

Structure activity relationship of nicotine analogs and erythrina alkaloids on the alpha-4 beta-2 Nicotinic acetylcholine receptor

Professional Positions

Post-doctoral Fellow - Dept. of Pharmcology and Therapeutics, University of Florida

Education

B.S., Stetson University

Publications

Kem WR, Wildeboer K, LeFrancois S, Raja M, Marszalec W, Braekman JC.  Nicotinic receptor inhibition by Tetraponera ant alkaloids. Cell Mol Neurobiol. 2004 Aug;24(4):535-51.  abstract

Kem WR, Mahnir VM, Prokai L, Papke RL, Cao X, LeFrancois S, Wildeboer K, Prokai-Tatrai K, Porter-Papke J, Soti F. Hydroxy metabolites of the Alzheimer's drug candidate 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (GTS-21): their molecular properties, interactions with brain nicotinic receptors, and brain penetration. Mol Pharmacol. 2004 Jan;65(1):56-67.  abstract

Abstracts Presented at Meetings Through Graduate Studies

Honors & Awards

Yan Zhang, Ph.D.

Advanced Concentration

Neuroscience

Mentor

Susan L. Semple-Rowland, Ph.D. 

Department

Neuroscience

Enrolled

August 1999 - May 2004

Dissertation Title

Effects of gap junction blockers on circadian regulation of iodopsin expression in embryonic retinal explant cultures

Professional Positions

Postdoctoral Associate, University of Houston

Education

Publications

Coleman JE, Zhang Y, Brown GA, Semple-Rowland SL.  Cone Cell Survival and Downregulation of GCAP1 Protein in the Retinas of GC1 Knockout Mice. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3397-403.  abstract

Zhang Y, Coleman JE, Fuchs GE, Semple-Rowland SL.  Circadian oscillator function in embryonic retina and retinal explant cultures. Brain Res Mol Brain Res. 2003 May 26;114(1):9-19.  abstract

Honors & Awards

Graduate Fellowship for Outstanding Research, UF College of Medicine, 2003

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