Biochemistry & Molecular Biology

Immunology & Microbiology

Neuroscience

Genetics

Molecular Cell Biology

Physiology & Pharmacology

Bahjat K

Bahjat R

Burkhardt

Casp

Cha

Clemente

Coberley C

Gao

Gary

Gussow

He

Jurgens

Seifert K

Seifert T

Sirninger

Starks

Tran

Whittaker

Wu W

Wu Y

Zeng

Keith S. Bahjat, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Michael J. Clare-Salzler, M.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1997 - August 2001

Dissertation Title

Dendritic cell development and distribution in type I diabetes:  Overcoming genetic defects and establishing tolerance via pharmacotherapeutic manipulation of dendritic cell populations in vivo

Professional Positions

Manager of Applications Development, Cytomation, Inc., Ft. Collins, CO

Education

B.S., Oklahoma State University, Stillwater, OK

Publications

Litherland SA, She JX, Schatz D, Fuller K, Hutson AD, Peng RH, Li Y, Grebe KM, Whittaker DS, Bahjat K, Hopkins D, Fang Q, Spies PD, North K, Wasserfall C, Cook R, Dennis MA, Crockett S, Sleasman J, Kocher J, Muir A, Silverstein J, Atkinson M, Clare-Salzler MJ. Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset. Pediatr Diabetes. 2003 Mar;4(1):10-8.  abstract

Oberholzer A, Oberholzer C, Bahjat KS, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Abouhamze Z, Tsai V, LaFace D, Hutchins B, Moldawer LL, Clare-Salzler MJ.  Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells. J Immunol. 2002 Apr 1;168(7):3412-8.  abstract

Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y, Balk SB, Strominger JL, Clare-Salzer M, Wilson SB.  Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13838-43.  abstract

Whittaker DS, Bahjat KS, Moldawer LL, Clare-Salzler MJ.  Autoregulation of human monocyte-derived dendritic cell maturation and IL-12 production by cyclooxygenase-2-mediated prostanoid production. J Immunol. 2000 Oct 15;165(8):4298-304.  abstract

Schowengerdt KO, Fricker FJ, Bahjat KS, Kuntz ST.  Increased expression of the lymphocyte early activation marker CD69 in peripheral blood correlates with histologic evidence of cardiac allograft rejection. Transplantation. 2000 May 27;69(10):2102-7.  abstract

Ottendorfer E, Ellis TM, Bahjat KS, Clare-Salzler M, Atkinson MA.  No alteration in T lymphocyte expression of CD40 ligand (CD154) in individuals with or at increased risk for insulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1999 Nov;84(11):4068-72.  abstract

Frances Rena Bahjat, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Michael J. Clare-Salzler, M.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1998 - August 2002

Dissertation Title

Characterization and genetic analysis of the resistance of nonobese diabetic mice to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and lethality

Professional Positions

Research Scientist, Nereus Pharmaceuticals, San Diego, CA

Education

B.S., Biology, Benedictine University, Lisle, IL

Publications

Blenman KR, Bahjat FR, Moldawer LL, Morel L.  Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse. Clin Immunol. 2004 Feb;110(2):124-33.  abstract

Palladino MA, Bahjat FR, Theodorakis EA, Moldawer LL. Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov. 2003 Sep;2(9):736-46.  abstract

Lam T, Ling T, Chowdhury C, Chao TH, Bahjat FR, Lloyd GK, Moldawer LL, Palladino MA, Theodorakis EA. Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3217-21.  abstract

Dharnidharka VR, Van Patten Y, Bahjat FR, Clare-Salzler M. Fas stimulation results in selective islet infiltrate apoptosis in situ and reversal of diabetes. Ann N Y Acad Sci. 2002 Apr;958:160-2.  abstract

Oberholzer A, Oberholzer C, Bahjat KS, Ungaro R, Tannahill CL, Murday M, Bahjat FR, Abouhamze Z, Tsai V, LaFace D, Hutchins B, Moldawer LL, Clare-Salzler MJ. Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells. J Immunol. 2002 Apr 1;168(7):3412-8.  abstract

Oberholzer A, Oberholzer C, Bahjat FR, Edwards CK 3rd, Moldawer LL. Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality. J Endotoxin Res. 2001;7(5):375-80.  abstract

Oberholzer C, Oberholzer A, Bahjat FR, Minter RM, Tannahill CL, Abouhamze A, LaFace D, Hutchins B, Clare-Salzler MJ, Moldawer LL. Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11503-8.  abstract

Minter RM, Ferry MA, Murday ME, Tannahill CL, Bahjat FR, Oberholzer C, Oberholzer A, LaFace D, Hutchins B, Wen S, Shinoda J, Copeland EM 3rd, Moldawer LL. Adenoviral delivery of human and viral IL-10 in murine sepsis. J Immunol. 2001 Jul 15;167(2):1053-9.  abstract

Minter RM, Ferry MA, Rectenwald JE, Bahjat FR, Oberholzer A, Oberholzer C, La Face D, Tsai V, Ahmed CM, Hutchins B, Copeland EM 3rd, Ginsberg HS, Moldawer LL. Extended lung expression and increased tissue localization of viral IL-10 with adenoviral gene therapy. Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):277-82.  abstract

Bahjat FR, Dharnidharka VR, Fukuzuka K, Morel L, Crawford JM, Clare-Salzler MJ, Moldawer LL. Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality. J Immunol. 2000 Dec 1;165(11):6559-67.  abstract

Nowak M, Gaines GC, Rosenberg J, Minter R, Bahjat FR, Rectenwald J, MacKay SL, Edwards CK 3rd, Moldawer LL. LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1202-9.  abstract

Josephs MD, Bahjat FR, Fukuzuka K, Ksontini R, Solorzano CC, Edwards CK 3rd, Tannahill CL, MacKay SL, Copeland EM 3rd, Moldawer LL. Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand. Am J Physiol Regul Integr Comp Physiol. 2000 May;278(5):R1196-201.  abstract

Honors & Awards

T32 NIH Training Grant Pre-doctoral Fellowship (2000-2001)

Freshman Chemistry Award from Indiana University (1994)

Award for Excellence in the field of Biology from Benedictine University (all semesters)

St. Benedict Award and scholarship for academic achievements (all semesters)

Benedictine University Dean’s list (all semesters)

Kim Blenman, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Laurence Morel, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled 

August 2000 - April 2005

Education

B.S., Chemistry, University of Florida

Dissertation Research

Apoptosis and inflammation in a mouse model of systemic lupus erythematosus

Publications

Morel L, Blenman KR, Croker BP, Wakeland EK. The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes. Proc Natl Acad Sci USA. 2001 Feb 13;98(4):1787-92.  abstract

Morel L, Croker BP, Blenman KR, Mohan C, Huang G, Gilkeson G, Wakeland EK. Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains. Proc Natl Acad Sci USA. 2000 Jun 6;97(12):6670-5.  abstract

Morel L, Yu Y, Blenman KR, Caldwell RA, Wakeland EK. Production of congenic mouse strains carrying genomic intervals containing SLE-susceptibility genes derived from the SLE-prone NZM2410 strain. Mamm Genome. 1996 May;7(5):335-9.  abstract

Honors & Awards

University Women's Club Scholarship for Graduate Students, 2004

Todd M. Brusko, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Mark Atkinson, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 2002 - August 2006

Dissertation Title

Professional Positions

Education

B.S., Microbiology & Cell Science, University of Florida

Publications

Araya CE, Wasserfall CH, Brusko TM, Mu W, Segal MS, Johnson RJ, Garin EH. A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol. 2006 Mar 7; [Epub ahead of print] abstract

Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA.  PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene. 2006 Mar 15;369C:134-141.  abstract

Brusko TM, Wasserfall CH, Agarwal A, Kapturczak MH, Atkinson MA.  An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4⁺CD25⁺ Regulatory T Cells. J Immunol. 2005 May 1;174(9):5181-6.  abstract

Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA.  Functional Defects and the Influence of Age on the Frequency of CD4⁺CD25⁺ T-Cells in Type 1 Diabetes. Diabetes. 2005 May;54(5):1407-14.  abstract

You S, Chen C, Lee WH, Brusko T, Atkinson M, Liu CP.  Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice. J Immunol. 2004 Dec 1;173(11):6777-85.  abstract

Haller MJ, Samyn M, Nichols WW, Brusko T, Wasserfall C, Schwartz RF, Atkinson M, Shuster JJ, Pierce GL, Silverstein JH.  Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes. Diabetes Care. 2004 Dec;27(12):2911-7.  abstract

Kapturczak MH, Wasserfall C, Brusko T, Campbell-Thompson M, Ellis TM, Atkinson MA, Agarwal A. Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse. Am J Pathol. 2004 Sep;165(3):1045-53.  abstract

Morales A, Wasserfall C, Brusko T, Carter C, Schatz D, Silverstein J, Ellis T, Atkinson M.  Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes. Diabetes Care. 2004 Aug;27(8):2010-4.  abstract

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY.  A functional variant of SUMO4, a new IkappaBalpha modifier, is associated with type 1 diabetes. Nat Genet. 2004 Aug;36(8):837-41.  abstract

Zhang YC, Powers M, Wasserfall C, Brusko T, Song S, Flotte T, Snyder RO, Potter M, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick HS, Agarwal A, Ellis TM, Atkinson MA. Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity. Gene Ther. 2004 Feb;11(3):233-40.  abstract

Goudy KS, Burkhardt BR, Wasserfall C, Song S, Campbell-Thompson ML, Brusko T, Powers MA, Clare-Salzler MJ, Sobel ES, Ellis TM, Flotte TR, Atkinson MA. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion. J Immunol. 2003 Sep 1;171(5):2270-8.  abstract

Zhang YC, Pileggi A, Agarwal A, Molano RD, Powers M, Brusko T, Wasserfall C, Goudy K, Zahr E, Poggioli R, Scott-Jorgensen M, Campbell-Thompson M, Crawford JM, Nick H, Flotte T, Ellis TM, Ricordi C, Inverardi L, Atkinson MA. Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice. Diabetes. 2003 Mar;52(3):708-16.  abstract

Goudy K, Wasserfall C, Burkhardt BA, Brusko T, Song S, Ellis T, Flotte T, Atkinson M.  Evaluation of mechanism, dose, and time dependency for AAV-IL-10 gene therapy in NOD mice.  Diabetes.  2002 Jun;51:1159 Suppl. 2.

Abstracts Presented at Meetings Through Graduate Studies

Wasserfall C, Schwartz RF, Simon G, Binns SA, Brusko T, Stalvey M, Clare-Salzler M, Song S, Campbell-Thompson M, Flotte T, Atkinson M.  A dichotomous role for interleukin-10 in the pathogenesis of type 1 diabetes.  DIABETES 54: A24-A24 Suppl. 1 2005

Tang M, Lu Y, Brusko T, Wasserfall C, Zhang B, Campbell-Thompson M, Atkinson MA, Song S.  Prevention of type 1 diabetes by AAT gene therapy is dose and time dependent.  DIABETES 54: A312-A313 Suppl. 1, 2005

Haller M, Cooper S, Putnam A, Freed B, Brusko T, Chase P, Atkinson M, Schatz D.  Autologous cord blood transfusion associated with prolonged honeymoon in a child with type 1 diabetes (T1D). DIABETES 54: A485-A485 Suppl. 1, 2005

Stalvey M, Wasserfall C, Brusko T, Flotte T, Schatz D, Atkinson M.  A pro-inflammatory state and hyperglycemia are associated with a cystic fibrosis related diabetes mouse model.  DIABETES 54: A645-A645 Suppl. 1, 2005

Todd M. Brusko, Clive H. Wasserfall, Michael J. Clare-Salzler, Desmond A. Schatz, Mark A. Atkinson.  65th Scientific Sessions; Meeting of the American Diabetes Association, 2005.  "Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T Cells in Type 1 Diabetes", Abstract Number: 246-OR.  

Todd M. Brusko, Clive H. Wasserfall, Schatz, Mark A. Atkinson.  65th Scientific Sessions; Meeting of the American Diabetes Association, 2005.  "Dynamics of CD4+CD25+ T Cells and Soluble CD25 in Type 1 Diabetes", Abstract Number: 248-OR.

Honors & Awards

2005 Graduate Fellowship for Outstanding Research, UF College of Medicine

Brant R. Burkhardt, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Maureen M. Goodenow, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1996 - December 2001

Dissertation Title

Phylogenetic and promoter analysis of the human immodeficiency virus type 1 (hiv-1) long terminal repeat and envelope regions from the tissues of vertically infected patients

Professional Positions

Postdoctoral Associate, Dept. Pathology, Immunology & Laboratory Medicine (Mark Atkinson, Ph.D.), UF College of Medicine

Education

B.S., New Jersey Institute of Technology, Newark, NJ

Ed.M.S., Clemson University, Clemson, SC

Publications

Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA.  PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene. 2006 Mar 15;369C:134-141.  abstract

Burkhardt BR, Parker MJ, Zhang YC, Song S, Wasserfall CH, Atkinson MA. Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice. FEBS Lett. 2005 Oct 24;579(25):5759-64.  abstract

Burkhardt BR, Loiler SA, Anderson JA, Kilberg MS, Crawford JM, Flotte TR, Goudy KS, Ellis TM, Atkinson M. Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells. Ann N Y Acad Sci. 2003 Nov;1005:237-41.  abstract

Goudy KS, Burkhardt BR, Wasserfall C, Song S, Campbell-Thompson ML, Brusko T, Powers MA, Clare-Salzler MJ, Sobel ES, Ellis TM, Flotte TR, Atkinson MA. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion. J Immunol. 2003 Sep 1;171(5):2270-8.  abstract

Perez EE, Rose SL, Peyser B, Lamers SL, Burkhardt B, Dunn BM, Hutson AD, Sleasman JW, Goodenow MM. Human immunodeficiency virus type 1 protease genotype predicts immune and viral responses to combination therapy with protease inhibitors (PIs) in PI-naive patients. J Infect Dis. 2001 Feb 15;183(4):579-88.  abstract

Kouba AJ, Burkhardt BR, Alvarez IM, Goodenow MM, Buhi WC. Oviductal plasminogen activator inhibitor-1 (PAI-1): mRNA, protein, and hormonal regulation during the estrous cycle and early pregnancy in the pig. Mol Reprod Dev. 2000 Jul;56(3):378-86.  abstract

Courtney B. Casp, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Wayne T. McCormack, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1998 - December 2003

Dissertation Title

Genetic association of catalase and antigen processing genes with vitiligo susceptibility   full text

Professional Positions

Law Student, Levin College of Law, University of Florida

Education

B.S., Biology, University of Richmond

Publications

Casp CB, She JX, McCormack WT.  Genes of the LMP/TAP cluster are associated with the human autoimmune disease vitiligo. Genes Immun. 2003 Oct;4(7):492-9.  abstract

Casp CB, She JX, McCormack WT.  Genetic association of the catalase gene (CAT) with vitiligo susceptibility. Pigment Cell Res. 2002 Feb;15(1):62-6.   abstract

Abstracts Presented at Meetings Through Graduate Studies

Kristensen, D., C.A. Bradley, M. Hao, S. Perkins, W.T. McCormack. 2000. Case/control association study of candidate genes for vitiligo susceptibility: tyrosine metabolism and immune response genes. 52nd Annual Meeting & Clin. Lab. Expo., Amer. Acad. Clin. Chem.

Bradley, C.A., D. Kristensen, M. Hao, S. Perkins, M. Marron, J.X. She, W.T. McCormack. Case/control association study of immune response genes and vitiligo susceptibility. 2000. FASEB J. 14(6):A1109.

Bradley, C.A., D. Kristensen, J.X. She, W.T. McCormack. 2001. Genetic association studies of immune response genes and vitiligo susceptibility. FASEB J. 15(4):A323.

McCormack, W.T., Bradley, C.A., D. Kristensen, J.X. She. 2001. Genetics of vitiligo susceptibility: Association studies of immune response genes. Pigment Cell Res. 14(3):231.

Casp, C.B., S.A. Litherland, J.-X. She, W.T. McCormack. 2002. Antigen processing and presentation genes in vitiligo susceptibility. FASEB J. 16(5):A1219.

Seunghee Cha, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Michael Humphreys-Beher, Ph.D.

Department

Oral Biology

Enrolled

August 1996 - December 2001

Dissertation Title

Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy

Professional Positions

Postdoctoral Associate, Dept. of Oral Biology, University of Florida College of Dentistry

Education

D.D.S., Yonsei University, Seoul, Korea

Publications

Gao J, Killedar S, Cornelius JG, Nguyen C, Cha S, Peck AB. Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun. 2006 Mar;26(2):90-103.  abstract

Gao J, Cha S, Jonsson R, Opalko J, Peck AB. Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjogren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum. 2004 Aug;50(8):2615-21. abstract

Cha S, Nagashima H, Peck AB, Humphreys-Beher MG.  IDD3 and IDD5 alleles from nod mice mediate Sjogren's syndrome-like autoimmunity. Adv Exp Med Biol. 2002;506(Pt B):1035-9.  abstract

Humphreys-Beher MG, Brayer J, Cha S, Nagashima H, Diggs S, Peck AB.  Immunogenetics of autoimmune exocrinopathy in the nod mouse: more than meets the eye. Adv Exp Med Biol. 2002;506(Pt B):999-1007.  abstract

Cha S, Nagashima H, Brown VB, Peck AB, Humphreys-Beher MG.  Two NOD Idd-associated intervals contribute synergistically to the development of autoimmune exocrinopathy (Sjogren's syndrome) on a healthy murine background. Arthritis Rheum. 2002 May;46(5):1390-8.  abstract

Cha S, Peck AB, Humphreys-Beher MG.  Progress in understanding autoimmune exocrinopathy using the non-obese diabetic mouse: an update. Crit Rev Oral Biol Med. 2002;13(1):5-16.  abstract

Cha S, van Blockland SC, Versnel MA, Homo-Delarche F, Nagashima H, Brayer J, Peck AB, Humphreys-Beher MG.  Abnormal organogenesis in salivary gland development may initiate adult onset of autoimmune exocrinopathy. Exp Clin Immunogenet. 2001;18(3):143-60.  abstract

Nagy A, Nagashima H, Cha S, Oxford GE, Zelles T, Peck AB, Humphreys-Beher MG.  Reduced oral wound healing in the NOD mouse model for type 1 autoimmune diabetes and its reversal by epidermal growth factor supplementation. Diabetes. 2001 Sep;50(9):2100-4.  abstract

Brayer JB, Cha S, Nagashima H, Yasunari U, Lindberg A, Diggs S, Martinez J, Goa J, Humphreys-Beher MG, Peck AB.  IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD.IL-4-gene knockout mouse model of Sjogren's syndrome. Scand J Immunol. 2001 Jul-Aug;54(1-2):133-40.  abstract

Clarke MY, Brayer J, Heintz K, Nagashima H, Cha S, Oxford GE, Nanni JM, Peck AB, Zelles T, Humphreys-Beher MG.  Differential absorption and distribution of epidermal growth factor and insulin-like growth factor in diabetic NOD mice. J Diabetes Complications. 2001 Mar-Apr;15(2):103-11.  abstract

Nguyen KH, Brayer J, Cha S, Diggs S, Yasunari U, Hilal G, Peck AB, Humphreys-Beher MG.  Evidence for antimuscarinic acetylcholine receptor antibody-mediated secretory dysfunction in nod mice. Arthritis Rheum. 2000 Oct;43(10):2297-306.  abstract

Brayer J, Lowry J, Cha S, Robinson CP, Yamachika S, Peck AB, Humphreys-Beher MG.  Alleles from chromosomes 1 and 3 of NOD mice combine to influence Sjogren's syndrome-like autoimmune exocrinopathy. J Rheumatol. 2000 Aug;27(8):1896-904.   abstract

Honors & Awards

Maui 2000 Conference Grant, Third International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes

Mary Ann Checkley, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Alfred S. Lewin, Ph.D.

Department

Molecular Genetics & Microbiology

Enrolled 

August 1998 - April 2005

Dissertation Research

Identification and characterization of potential virulence factors expressed by Candida albicans during oropharyngeal candidiasis in HIV-infected patients

Publications

Cheng S, Clancy CJ, Checkley MA, Handfield M, Hillman JD, Progulske-Fox A, Lewin AS, Fidel PL, Nguyen MH. Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Mol Microbiol. 2003 Jun;48(5):1275-88.  abstract

Jose C. Clemente, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Ben M. Dunn, Ph.D.

Department

Biochemistry & Molecular Biology

Enrolled

August 1998 - May 2003

Dissertation Title

Analysis of therapy selected non-active site mutations in the HIV-1 protease

Professional Positions

Postdoctoral Associate, Dept. Biochemistry & Molecular Biology, UF College of Medicine

Education

B.S., University of Florida

Publications

Clemente JC, Hemrajani R, Blum LE, Goodenow MM, Dunn BM.  Secondary Mutations M36I and A71V in the Human Immunodeficiency Virus Type 1 Protease Can Provide an Advantage for the Emergence of the Primary Mutation D30N. Biochemistry. 2003 Dec 30;42(51):15029-35.  abstract

Wlodawer A, Li M, Gustchina A, Oyama H, Oda K, Beyer BB, Clemente J, Dunn BM.  Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate. Biochem Biophys Res Commun. 2004 Feb 6;314(2):638-45.  abstract

Carter R. Coberley, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Maureen M. Goodenow, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1997 - August 2002

Dissertation Title

Phenotypic and functional genomic characterization of immune-cell reservoirs for Human Immunodeficiency Virus Type-1  (full text)

Professional Positions

Bioinformatics Research Analyst II, Gene Logic Inc., Gaithersburg, MD

Education

B.S., Microbiology, Oregon State University, Corvallis, OR

Publications

Kohler JJ, Tuttle DL, Coberley CR, Sleasman JW, Goodenow MM.  Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. J Leukoc Biol. 73(3):407-16. 2003.  abstract

Honors & Awards

Waldo-Cummings Outstanding Student Award, Oregon State University, 1993

Microbiology Students Association Vice President, Oregon State University, 1993-1994

Phi Kappa Phi National Honor Society, Oregon State University, 1993-1994

NIH Rheumatology Training Grant Awardee, UF College of Medicine, 2001

Sadie S. Coberley, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Paul A. Klein, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1997 - August 2002

Dissertation Title

The role of herpesviruses in marine turtle diseases  (full text)

Professional Positions

Research Associate, US Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, MD

Education

Publications

Coberley SS, Condit RC, Herbst LH, Klein PA.  Identification and expression of immunogenic proteins of a disease-associated marine turtle herpesvirus. J Virol. 2002 Oct;76(20):10553-8.  abstract

Coberley SS, Herbst LH, Ehrhart LM, Bagley DA, Hirama S, Jacobson ER, Klein PA.  Survey of Florida green turtles for exposure to a disease-associated herpesvirus. Dis Aquat Organ. 2001 Dec 5;47(3):159-67.  abstract

Coberley SS, Herbst LH, Brown DR, Ehrhart LM, Bagley DA, Schaf SA, Moretti RH, Jacobson ER, Klein PA.  Detection of antibodies to a disease-associated herpesvirus of the green turtle, Chelonia mydas. J Clin Microbiol. 2001 Oct;39(10):3572-7.  abstract

Honors & Awards

National Academies Research Associate Award, "Use of Filovirus Specific Antibodies to Evaluate Mechanisms of Virus Neutralization and Protective Epitopes", 2002

Yiqian Dong, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Robert Burne, Ph.D. 

Department

Oral Biology

Enrolled

August 2001 - December 2004

Dissertation Title

The arginine deiminase system of Streptococcus gordonii DL-1

Professional Positions

Education

Publications

Dong Y, Chen YY, Burne RA.  Control of expression of the arginine deiminase operon of Streptococcus gordonii by CcpA and Flp. J Bacteriol. 2004 Apr;186(8):2511-4.  abstract

Dong Y, Chen YY, Snyder JA, Burne RA.  Isolation and molecular analysis of the gene cluster for the arginine deiminase system from Streptococcus gordonii DL1. Appl Environ Microbiol. 2002 Nov;68(11):5549-53.  abstract

Brian R. Dorn, Ph.D., J.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Ann Progulske-Fox, Ph.D.

Department

Oral Biology

Enrolled

August 1997 - May 2003

Dissertation Title

Interactions between Porphyromonas gingivalis and endothelial cells

Professional Positions

Associate Attorney, Merchant and Gould, Minneapolis, MN

Education

B.S., Microbiology, University of Michigan, Ann Arbor, MI

M.S., Oral Biology, UF College of Dentistry  

J.D., UF Levin College of Law

Publications

Dorn BR, Harris LJ, Wujick CT, Vertucci FJ, Progulske-Fox A.  Invasion of vascular cells in vitro by Porphyromonas endodontalis. Int Endod J. 2002 Apr;35(4):366-71.  abstract

Dorn BR, Dunn WA Jr, Progulske-Fox A.  Bacterial interactions with the autophagic pathway. Cell Microbiol. 2002 Jan;4(1):1-10.  abstract

Dorn BR, Dunn WA Jr, Progulske-Fox A.  Porphyromonas gingivalis traffics to autophagosomes in human coronary artery endothelial cells. Infect Immun. 2001 Sep;69(9):5698-708.  abstract

Dorn BR, Burks JN, Seifert KN, Progulske-Fox A.  Invasion of endothelial and epithelial cells by strains of Porphyromonas gingivalis. FEMS Microbiol Lett. 2000 Jun 15;187(2):139-44.  abstract

Progulske-Fox A, Kozarov E, Dorn B, Dunn W Jr, Burks J, Wu Y.  Porphyromonas gingivalis virulence factors and invasion of cells of the cardiovascular system. J Periodontal Res. 1999 Oct;34(7):393-9.  abstract

Dorn BR, Dunn WA Jr, Progulske-Fox A.  Invasion of human coronary artery cells by periodontal pathogens. Infect Immun. 1999 Nov;67(11):5792-8.  abstract

Dorn BR, Leung KL, Progulske-Fox A.  Invasion of human oral epithelial cells by Prevotella intermedia. Infect Immun. 1998 Dec;66(12):6054-7.  abstract

Honors & Awards

Travel Grants, American Society for Microbiology, 1998, 1999

Travel Grants, University of Florida Graduate Student Council, 1998, 1999, 2000

Finalist, American Association for Dental Research/Warner-Lambert Hatton Competition, American Assoc. for Dental Research, 2000

Finalist, International Association for Dental Research/Warner-Lambert Hatton Competition, International Assoc. for Dental Research, 2000

First Place, Immunology & Microbiology, Medical Guild Graduate Student Research Competition, UF College of Medicine, 2000

Biyan Duan, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Laurence Morel, Ph.D.

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 2000 - May 2006

Dissertation Title

Characterization of the B cells in lupus-prone and resistant mouse models

Professional Positions

Education

Publications

Xu Z, Duan B, Croker BP, Wakeland EK, Morel L. Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci. J Immunol. 2005 Jul 15;175(2):936-43. abstract

Erickson LD, Lin LL, Duan B, Morel L, Noelle RJ. A genetic lesion that arrests plasma cell homing to the bone marrow. Proc Natl Acad Sci USA. 2003 Oct 28;100(22):12905-10.  abstract

Juehua Gao, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Ammon B. Peck, Ph.D. 

Department

Pathology, Immunology & Laboratory Medicine

Enrolled

August 1999 - December 2004

Dissertation Title

Biological functions and molecular mechanisms of the interleukin 4 signaling pathways in autoimmune exocrinopathy using the NOD.B10-H2b mouse model of Sjögren's Syndrome

Professional Positions

Education

Publications

Gao J, Killedar S, Cornelius JG, Nguyen C, Cha S, Peck AB. Sjogren's syndrome in the NOD mouse model is an interleukin-4 time-dependent, antibody isotype-specific autoimmune disease. J Autoimmun. 2006 Mar;26(2):90-103.  abstract

Gao J, Cha S, Jonsson R, Opalko J, Peck AB.  Detection of anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjogren's syndrome patients by use of a transfected cell line assay. Arthritis Rheum. 2004 Aug;50(8):2615-21.  abstract

Lee William Gary, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

David C. Bloom, Ph.D.

Department

Molecular Genetics & Microbiology

Enrolled

August 1999 - May 2004

Dissertation Title

Identification of a virulence function in Herpes simplex virus type I mapping to the latency-associated transcript locus

Professional Positions

Postdoctoral Fellow, Department of Neurology, University of Colorado, Denver, CO

Education

B.S., Mars Hill College, Mars Hill, NC

Publications

Sun A, Devi-Rao GV, Rice MK, Gary LW, Bloom DC, Sandri-Goldin RM, Ghazal P, Wagner EK.  Immediate-early expression of the herpes simplex virus type 1 ICP27 transcript is not critical for efficient replication in vitro or in vivo. J Virol. 2004 Oct;78(19):10470-8.  abstract

Ann Griswold, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Department

Enrolled 

August 2001 - May 2006

Dissertation Title

Ammonia-generating mechanisms of mutans streptococci

Professional Positions

Education

B.S.,  Microbiology,  University of Maryland at College Park

Publications

Griswold AR, Jameson-Lee M, Burne RA. Regulation and physiologic significance of the agmatine deiminase system of Streptococcus mutans UA159.  J Bacteriol. 2006 Feb;188(3):834-41. abstract

Griswold A, Chen YY, Snyder JA, Burne RA.  Characterization of the arginine deiminase operon of Streptococcus rattus FA-1. Appl Environ Microbiol. 2004 Mar;70(3):1321-7. abstract

Griswold AR, Chen YY, Burne RA.  Analysis of an agmatine deiminase gene cluster in Streptococcus mutans UA159. J Bacteriol. 2004 Mar;186(6):1902-4. abstract

First Place, Immunology & Microbiology Advanced Concentration, Medical Guild Graduate Student Research Concentration, 2005

Bronze Medal Finalist, Medical Guild Graduate Student Research Competition, 2005

Anne Gussow, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

David C. Bloom, Ph.D.

Department

Molecular Genetics & Microbiology

Enrolled

January 2000 - May 2004

Dissertation Title

Characterization of a transgenic mouse expressing the Herpes simplex virus type 1 latency-associated transcript

Professional Positions

Postdoctoral Associate, National Cancer Institute, National Institutes of Health, Bethesda, MD

Education

B.S., Susquehanna University, Selinsgrove, PA

Unhwan Ha, Ph.D.

Advanced Concentration

Immunology & Microbiology

Mentor

Shouguang Jin, Ph.D.

Department

Molecular Genetics & Microbiology

Enrolled

August 1999 - August 2002

Dissertation Title

Pathogenicity of Pseudomonas aeruginosa:  Bacterial invasion, intracellular survival and in vivo gene expression

Professional Positions

Postdoctoral Associate, Molecular Genetics & Microbiology (Shouguang Jin, Ph.D.), UF College of Medicine

Postdoctoral Fellow, House Ear Institute, Section on Signal Transduction, Los Angeles, CA

Education

B.S., Engineering, Korea University

M.S., Korea University

Publications

Ha UH, Wang Y, Jin S.  DsbA of Pseudomonas aeruginosa is essential for multiple virulence factors. Infect Immun. 2003 Mar;71(3):1590-5.  abstract

Wang Y, Ha U,