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Biochemistry & Molecular Biology Alumni |
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Biochemistry & Molecular Biology Alumni |
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Biochemistry & Molecular Biology |
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Clint W. Abner, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2002 |
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Dissertation Title |
Biochemical analysis of human base excision repair |
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Professional Positions |
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Postdoctoral Associate, St. Jude Children's Research Hospital, Memphis, TN |
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Publications |
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Vallur AC, Feller JA, Abner CW, Tran RK, Bloom LB. Effects of hydrogen bonding within a damaged base pair on the activity of wild type and DNA-intercalating mutants of human alkyladenine DNA glycosylase. J Biol Chem. 2002 Aug 30;277(35):31673-8. abstract |
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Abner CW, Lau AY, Ellenberger T, Bloom LB. Base excision and DNA binding activities of human alkyladenine DNA glycosylase are sensitive to the base paired with a lesion. J Biol Chem. 2001 Apr 20;276(16):13379-87. abstract |
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Bret B. Beyer, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - May 2003 |
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Dissertation Title |
Targeted chromogenic octapeptide combinatorial libraries: Exploration of the primary and extended subsite specificities of human and malarial aspartic endopeptidases |
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Professional Positions |
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Postdoctoral Associate, St. Jude Children's Research Hospital, Memphis, TN |
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Publications |
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Wlodawer A, Li M, Gustchina A, Oyama H, Oda K, Beyer BB, Clemente J, Dunn BM. Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate. Biochem Biophys Res Commun. 2004 Feb 6;314(2):638-45. abstract |
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Oyama H, Hamada T, Ogasawara S, Uchida K, Murao S, Beyer BB, Dunn BM, Oda K. A CLN2-related and thermostable serine-carboxyl proteinase, kumamolysin: cloning, expression, and identification of catalytic serine residue. J Biochem (Tokyo). 2002 May;131(5):757-65. abstract |
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Timothy D. Blalock, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - August 2003 |
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Dissertation Title |
Biochemical characterization and action of connective tissue growth factor and its receptor in corneal scarring (PDF) |
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Professional Positions |
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Postdoctoral Associate, Schepens Eye Research Institute, Harvard University |
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Publications |
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Esson DW, Neelakantan A, Iyer SA, Blalock TD, Balasubramanian L, Grotendorst GR, Schultz GS, Sherwood MB. Expression of connective tissue growth factor after glaucoma filtration surgery in a rabbit model. Invest Ophthalmol Vis Sci. 2004 Feb;45(2):485-91. abstract |
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Ollivier FJ, Brooks DE, Schultz GS, Blalock TD, Andrew SE, Komaromy AM, Cutler TJ, Lassaline ME, Kallberg ME, Van Setten GB. Connective tissue growth factor in tear film of the horse: detection, identification and origin. Graefes Arch Clin Exp Ophthalmol. 2003 Nov 28 abstract |
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Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, Fujii M, Blalock TD, Schultz GS, Sowers A, Anzano MA, Mitchell JB, Russo A, Roberts AB. Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol. 2003 Dec;163(6):2247-57. abstract |
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Daniels JT, Schultz GS, Blalock TD, Garrett Q, Grotendorst GR, Dean NM, Khaw PT. Mediation of transforming growth factor-beta(1)-stimulated matrix contraction by fibroblasts: a role for connective tissue growth factor in contractile scarring. Am J Pathol. 2003 Nov;163(5):2043-52. abstract |
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Ollivier FJ, Brooks DE, Kallberg ME, Komaromy AM, Lassaline ME, Andrew SE, Gelatt KN, Stevens GR, Blalock TD, van Setten GB, Schultz GS. Evaluation of various compounds to inhibit activity of matrix metalloproteinases in the tear film of horses with ulcerative keratitis. Am J Vet Res. 2003 Sep;64(9):1081-7. abstract |
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Mazaheri MK, Schultz GS, Blalock TD, Caffee HH, Chin GA. Role of connective tissue growth factor in breast implant elastomer capsular formation. Ann Plast Surg. 2003 Mar;50(3):263-8. abstract |
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Blalock TD, Duncan MR, Varela JC, Goldstein MH, Tuli SS, Grotendorst GR, Schultz GS. Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy. Invest Ophthalmol Vis Sci. 2003 May;44(5):1879-87. abstract |
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van Setten GB, Blalock TD, Grotendorst G, Schultz GS. Detection of connective tissue growth factor (CTGF) in human tear fluid: preliminary results. Acta Ophthalmol Scand. 2003 Feb;81(1):51-3. abstract |
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van Setten G, Aspiotis M, Blalock TD, Grotendorst G, Schultz G. Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring. Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):135-9. abstract |
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van Setten GB, Blalock TD, Grotendorst G, Schultz GS. Detection of connective tissue growth factor in human aqueous humor. Ophthalmic Res. 2002 Sep-Oct;34(5):306-8. abstract |
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Chin Chen, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - May 2004 |
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Dissertation Title |
Nutrient
regulation of the human CCAAT/enhancer binding protein beta and its
relation to transcriptional control of the human asparagine synthetase
gene |
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Professional Positions |
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Postdoctoral Associate, Stanford University |
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Education |
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M.S., Molecular Genetics and Microbiology, University Florida |
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B.S., Technology for Medical Sciences, Kaohsiung, Taiwan |
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Publications |
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Zhong C, Chen C, Kilberg MS. Characterization of the nutrient-sensing response unit in the human asparagine synthetase promoter. Biochem J. 2003 Jun 1;372(Pt 2):603-9. abstract |
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Chang SH, Barbosa-Tessmann I, Chen C, Kilberg MS, Agarwal A. Glucose deprivation induces heme oxygenase-1 gene expression by a pathway independent of the unfolded protein response. J Biol Chem. 2002 Jan 18;277(3):1933-40. abstract |
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Siu F, Chen C, Zhong C, Kilberg MS. CCAAT/enhancer-binding protein-beta is a mediator of the nutrient-sensing response pathway that activates the human asparagine synthetase gene. J Biol Chem. 2001 Dec 21;276(51):48100-7. abstract |
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Barbosa-Tessmann IP, Chen C, Zhong C, Siu F, Schuster SM, Nick HS, Kilberg MS. Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. J Biol Chem. 2000 Sep 1;275(35):26976-85. abstract |
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Barbosa-Tessmann IP, Chen C, Zhong C, Schuster SM, Nick HS, Kilberg MS. Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression. J Biol Chem. 1999 Oct 29;274(44):31139-44. abstract |
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Honors & Awards |
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Winner, Nutrient-Gene Interaction Poster Competition, American Society for Nutritional Sciences, Experimental Biology, San Diego, 2003 |
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American Society for Biochemistry and Molecular Biology Graduate/Postdoctoral Travel Award, 2002 |
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Certificate of Academic Achievement, University of Florida, 1999-2003 |
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Christopher A. Davis, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1997 - December 2001 |
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Dissertation Title |
Manganese superoxide dismutase: Post-transcriptionsl regulation and cytoprotective potential |
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Professional Positions |
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Postdoctoral Associate, University of Texas, Southwestern |
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Publications |
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Davis CA, Hearn AS, Fletcher B, Bickford J, Garcia JE, Leveque V, Melendez JA, Silverman DN, Zucali J, Agarwal A, Nick HS. Potent anti-tumor effects of an active site mutant of human manganese-superoxide dismutase. Evolutionary conservation of product inhibition. J Biol Chem. 2004 Mar 26;279(13):12769-76. abstract |
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Davis CA, Nick HS, Agarwal A. Manganese superoxide dismutase attenuates Cisplatin-induced renal injury: importance of superoxide. J Am Soc Nephrol. 2001 Dec;12(12):2683-90. abstract |
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Davis CA, Monnier JM, Nick HS. A coding region determinant of instability regulates levels of manganese superoxide dismutase mRNA. J Biol Chem. 2001 Oct 5;276(40):37317-26. abstract |
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Luca Di Noto, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1996 - May 2002 |
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Dissertation Title |
Biochemical investigation of tau and MAP2 polymerization implications for neuropathic filament assembly in Alzheimer's disease |
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Professional Positions |
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National Institutes of Health |
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Publications |
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DeTure MA, Di Noto L, Purich DL. In vitro assembly of Alzheimer-like filaments. How a small cluster of charged residues in Tau and MAP2 controls filament morphology. J Biol Chem. 2002 Sep 20;277(38):34755-9. abstract |
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Di Noto L, DeTure MA, Purich DL. Disulfide-cross-linked tau and MAP2 homodimers readily promote microtubule assembly. Mol Cell Biol Res Commun. 1999 Jul;2(1):71-6. abstract |
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Aaron T. Dossey |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2001 - August 2006 |
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Dissertation Title |
Chemical Biodiversity and Signaling: Detailed Analysis of FMRFamide-Like Neuropeptides and Other Natural Products by NMR and Bioinformatics |
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Professional Positions |
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Education |
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B.S., Biochemistry, Oklahoma State University |
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Publications |
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Dossey AT, Reale V, Chatwin H, Zachariah C, Debono M, Evans PD, Edison AS. NMR Analysis of Caenorhabditis elegans FLP-18 Neuropeptides: Implications for NPR-1 Activation. Biochemistry. 2006 Jun 20;45(24):7586-7597. abstract |
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Abstracts Presented at Meetings during Graduate Studies |
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Aaron T. Dossey, Vincenzina Reale, Heather Chatwin, Cherian Zachariah, Mario deBono, Peter D. Evans, and Arthur S. Edison, NMR Analysis of C. elegans FLP-18 Neuropeptides: Implications for NPR-1 Activation, (2006) Biochemistry, In Press |
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"NMR analysis of defensive spray from individual stick insects (Anisomorpha buprestoides)", Aaron T. Dossey, Spencer Walse, James R. Rocca, and Arthur S. Edison, Oral Presentation given at the American Chemical Society (ACS) 82nd Annal Florida Meeting and Exposition FAME - 2006 |
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"Comparative Study of Sequence, Chemical, and Functional Properties of FMRFamide-Like Neuropeptides and Their Precursor DNAs/Proteins in Caenorhabditis elegans and C. briggsae”, Aaron T. Dossey and Arthur S. Edison, Poster Presented at the University of Florida Bioinformatics Workshop - 2005 |
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“Differential Activities Of NPR-1 Peptide Ligands are Regulated by Differences in Secondary Structures of the N-Termini”, A. Dossey, C. Zachariah, A. S. Edison, M. de Bono, and P. D. Evans, Poster Presented at the Experimental Nuclear Magnetic Resonance Conference (ENC), Asilomar Conference Grounds, Pacific Grove, CA - 2004 |
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“Optimization of the production of the extracellular domain of the FMRFamide-gated sodium channel for structural studies”, Aaron T. Dossey, Cherian Zachariah, and Arthur S. Edison, Poster Presented at the ENC, Savannah, GA - 2003 |
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Honors & Awards |
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2005 Scholarship toward Tuition Awarded - Woods Hole Oceanographic |
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2004 Student Travel Award - Experimental Nuclear Magnetic Resonance Conference (ENC) |
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2001 - 2004 Grinter Fellowship |
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2001 Outstanding Senior Award from the Department of Biochemistry |
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2000 Outstanding Biochemistry Award from the American Institute of Chemists |
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1998-present Member of Golden Key National Honor Society |
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2000-2001 Lew Wentz Foundation Research Project Fellowship |
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1996-1997 Freshman Research Scholar's Program |
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David M. Duda, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2003 |
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Dissertation Title |
Structural analysis of proton transfer in human carbonic anhydrase |
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Professional Positions |
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Postdoctoral Associate, St. Jude Children's Research Hospital, Memphis, TN |
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Publications |
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Duda DM, Tu C, Fisher SZ, An H, Yoshioka C, Govindasamy L, Laipis PJ, Agbandje-McKenna M, Silverman DN, McKenna R. Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. Biochemistry. 2005 Aug 2;44(30):10046-53. abstract |
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Fisher Z, Hernandez Prada JA, Tu C, Duda D, Yoshioka C, An H, Govindasamy L, Silverman DN, McKenna R. Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II. Biochemistry. 2005 Feb 1;44(4):1097-105. abstract |
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Gumz ML, Duda D, McKenna R, Wingo CS, Cain BD. Molecular modeling of the rabbit colonic (HKalpha2a) H(+), K(+) ATPase. J Mol Model (Online). 2003 Oct;9(5):283-9. abstract |
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Duda D, Govindasamy L, Agbandje-McKenna M, Tu C, Silverman DN, McKenna R. The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer. Acta Crystallogr D Biol Crystallogr. 2003 Jan;59(Pt 1):93-104. abstract |
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Tu C, Qian M, An H, Wadhwa NR, Duda D, Yoshioka C, Pathak Y, McKenna R, Laipis PJ, Silverman DN. Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase. J Biol Chem. 2002 Oct 11;277(41):38870-6. abstract |
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Duda DM, Yoshioka C, Govindasamy L, An H, Tu C, Silverman DN, McKenna R. Crystallization and preliminary X-ray analysis of human carbonic anhydrase III. Acta Crystallogr D Biol Crystallogr. 2002 May;58(Pt 5):849-52. abstract |
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An H, Tu C, Duda D, Montanez-Clemente I, Math K, Laipis PJ, McKenna R, Silverman DN. Chemical rescue in catalysis by human carbonic anhydrases II and III. Biochemistry. 2002 Mar 5;41(9):3235-42. abstract |
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Duda D, Tu C, Qian M, Laipis P, Agbandje-McKenna M, Silverman DN, McKenna R. Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II. Biochemistry. 2001 Feb 13;40(6):1741-8. abstract |
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Nathan E. Goldfarb, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - May 2003 |
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Dissertation Title |
Ion switch residues that mediate the pH-dependent conformational change of "short" recombinant human pseudocathepsin D |
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Publications |
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Wlodawer A, Li M, Gustchina A, Dauter Z, Uchida K, Oyama H, Goldfarb NE, Dunn BM, Oda K. Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase. Biochemistry. 2001 Dec 25;40(51):15602-11. abstract |
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Abstracts Presented at Meetings during Graduate Studies |
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Bret B. Beyer, Alfred Y. Chung, Jodie V. Johnson, Nathan E. Goldfarb, José C. Clemente, Rebecca E. Moose, Kyle D. Perry, and Ben M. Dunn. Analysis of aspartic proteinase specificity utilizing targeted chromogenic combinatorial peptide libraries. FASEB Journal 2001, Vol 15, Iss 4, A539-A539. |
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Tammy B. Grabar, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - August 2004 |
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Dissertation Title |
Contributions of the individual b subunits to the function of the peripheral stalk of F1F0 ATP synthase |
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Professional Positions |
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Education |
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B.S., Microbiology, University of Florida |
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Publications |
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Grabar TB, Cain BD. Genetic complementation between mutant b subunits in F1F0 ATP synthase. J Biol Chem. 2004 Jul 23;279(30):31205-11. abstract |
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Hardy AW, Grabar TB, Bhatt D, Cain BD. Mutagenesis studies of the F1F0 ATP synthase b subunit membrane domain. J Bioenerg Biomembr. 2003 Oct;35(5):389-97. abstract |
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Grabar TB, Cain BD. Integration of b subunits of unequal lengths into F1F0-ATP synthase. J Biol Chem. 2003 Sep 12;278(37):34751-6. abstract |
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Terry B. Green, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - December 2003 |
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Dissertation Title |
Structure-Function studies of ia3, a potent inhibitor of yeast proteinase A |
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Professional Positions |
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US Department of Agriculture, Gainesville, FL |
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Publications |
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Ganesh OK, Green TB, Edison AS, Hagen SJ. Characterizing the Residue Level Folding of the Intrinsically Unstructured IA(3). Biochemistry. 2006 Nov 14;45(45):13585-13596. abstract |
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Green T, Perry K, Smith L, Phylip LH, Logan TM, Hagen SJ, Dunn BM, Edison A. Ia 3, a yeast proteinase a inhibitor, is intrinsically unstructured in solution. ScientificWorld Journal. 2002 Jan 2;2(1 Suppl 2):99-101. abstract |
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Michelle L. Gumz, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
The
colonic (HK&2) H+,K+
ATPase and aldosterone regulation in the kidney |
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Education |
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B.S., Biochemistry, University of California, Riverside |
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Publications |
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Gumz ML, Duda D, McKenna R, Wingo CS, Cain BD. Molecular modeling of the rabbit colonic (HKalpha2a) H(+), K(+) ATPase. J Mol Model (Online). 2003 Oct;9(5):283-9. abstract |
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Gumz ML, Popp MP, Wingo CS, Cain BD. Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line. Am J Physiol Renal Physiol. 2003 Oct;285(4):F664-73. abstract |
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Abstracts Presented at Meetings during Graduate Studies |
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Zies D, Campbell W, Gumz M, Cain B. Molecular characterization of the rabbit renal HKa2 gene. 2000 The FASEB Journal 14(8): A1568. |
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Honors & Awards |
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Graduate Fellowship for Outstanding Research, UF College of Medicine, 2003 |
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Jose A. Hernandez Prada, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2002 - May 2006 |
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Dissertation Title |
The Exploit of Structural Variability in Proteins by Natural Selection and Rational Design |
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Education |
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B.S., Biochemistry, University of Miami, FL |
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Publications |
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Bhatt D, Tu C, Fisher SZ, Hernandez Prada JA, McKenna R, Silverman DN. Proton transfer in a Thr200His mutant of human carbonic anhydrase II. Proteins. 2005 Nov 1;61(2):239-45. abstract |
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Fisher Z, Hernandez Prada JA, Tu C, Duda D, Yoshioka C, An H, Govindasamy L, Silverman DN, McKenna R. Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II. Biochemistry. 2005 Feb 1;44(4):1097-105. abstract |
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Hernandez Prada JA, Haire RN, Cannon JP, Litman GW, Ostrov DA. Related Articles, Links Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae. Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):2022-4. abstract |
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Yoder JA, Litman RT, Mueller MG, Desai S, Dobrinski KP, Montgomery JS, Buzzeo MP, Ota T, Amemiya CT, Trede NS, Wei S, Djeu JY, Humphray S, Jekosch K, Hernandez Prada JA, Ostrov DA, Litman GW. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15706-11. abstract |
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Huentelman MJ, Zubcevic J, Hernandez Prada JA, Xiao X, Dimitrov DS, Raizada MK, Ostrov DA. Structure-Based Discovery of a Novel Angiotensin-Converting Enzyme 2 Inhibitor. Hypertension. 2004 Oct 18;44:1-4. abstract |
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Jannet Kocerha, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - August 2005 |
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Dissertation Title |
Regulation of the steroidogenic acute regulatory protein (STAR) by cAMP and transforming growth factor-beta (tgf-beta) dependent pathways (PDF) |
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Education |
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B.A., Chemistry, Indiana University |
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Dissertation Research |
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Regulation of the Steroidogenic Acute Regulatory Protein (STAR) by cAMP and Transforming Growth Factor-Beta (TGF-Beta) Dependent Pathways |
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Publications |
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Denslow ND, Kocerha J, Sepulveda MS, Gross T, Holm SE. Gene expression fingerprints of largemouth bass (Micropterus salmoides) exposed to pulp and paper mill effluents. Mutat Res. 2004 Aug 18;552(1-2):19-34. abstract |
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Kelly M. Leach, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - August 2003 |
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Dissertation Title |
Transcription and transcriptional control in the human beta-globin locus |
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Professional Positions |
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Postdoctoral Associate, Johns Hopkins University |
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Education |
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B.S., Microbiology & Cell Science, University of Florida |
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Publications |
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Dame C, Sola MC, Lim KC, Leach KM, Fandrey J, Ma Y, Knopfle G, Engel JD, Bungert J. Hepatic erythropoietin gene regulation by GATA-4. J Biol Chem. 2004 Jan 23;279(4):2955-61. abstract |
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Leach KM, Vieira KF, Kang SH, Aslanian A, Teichmann M, Roeder RG, Bungert J. Characterization of the human beta-globin downstream promoter region. Nucleic Acids Res. 2003 Feb 15;31(4):1292-301. abstract |
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Leach KM, Nightingale K, Igarashi K, Levings PP, Engel JD, Becker PB, Bungert J. Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly. Mol Cell Biol. 2001 Apr;21(8):2629-40. abstract |
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Honors & Awards |
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Alumni Fellowship, UF, 2000-2003 |
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Boyce Award, UF Dept. of Biochemistry & Molecular Biology, 2001 and 2002 |
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Medical Guild Award for Research Excellence, UF College of Medicine, 2002 |
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Padraic Levings, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - April 2005 |
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Dissertation Title |
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Professional Positions |
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Postdoctoral Fellow, Department of Biochemistry, UF |
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Education |
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Publications |
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Gouze JN, Gouze E, Popp MP, Bush ML, Dacanay EA, Kay JD, Levings PP, Patel KR, Saran JS, Watson RS, Ghivizzani SC. Exogenous glucosamine effectively protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Res Ther. 2006 Nov 16;8(6):R173 abstract |
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Kang SH, Levings PP, Andersen F, Laipis PJ, Berns KI, Zori RT, Bungert J. Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region. Genes Cells. 2004 Nov;9(11):1043-53. abstract |
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Vieira KF, Levings PP, Hill MA, Crusselle VJ, Kang SH, Engel JD, Bungert J. Recruitment of transcription complexes to the beta -globin gene locus in vivo and in vitro. J Biol Chem. 2004 Nov 26;279(48):50350-50357. abstract |
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Levings PP, Bungert J. The human beta-globin locus control region. Eur J Biochem. 2002 Mar;269(6):1589-99. abstract |
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Leach KM, Nightingale K, Igarashi K, Levings PP, Engel JD, Becker PB, Bungert J. Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly. Mol Cell Biol. 2001 Apr;21(8):2629-40. abstract |
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Honors & Awards |
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First Place, Biochemistry & Molecular Biology Advanced Concentration, Medical Guild Graduate Student Research Concentration, 2005 |
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Bronze Medal Finalist, Medical Guild Graduate Student Research Competition, 2005 |
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Peng Liu |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2001 - August 2006 |
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Dissertation Title |
Enzymatic Characterization, Subsite Specificity Exploration, and Inhibition Analysis of Malarial Aspartic Proteinases Using Enzyme Kinetics, Combinatorial Chemistry, and Molecular Modeling |
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Professional Positions |
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Education |
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B.S., Biotechnology, Peking University Health Science Center (P.R. China) |
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Publications |
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Gutierrez-de-Teran H, Nervall M, Ersmark K, Liu P, Janka LK, Dunn B, Hallberg A, Aqvist J. Inhibitor Binding to the Plasmepsin IV Aspartic Protease from Plasmodium falciparum. Biochemistry. 2006 Sep 5;45(35):10529-10541. abstract |
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Honors & Awards |
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Outstanding International Student Award, UF International Center & College of Medicine, 2005 Outstanding International Student Award, UF International Center & College of Medicine, 2006 |
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Rebecca E. Moose, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1999 - May 2004 |
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Dissertation Title |
Kinetic
and structural analysis of pepsin inhibitor-3 from Ascaris suum |
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Education |
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B.S., Microbiology & Cell Science, University of Florida |
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Publications |
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Rasmussen SA, Overman J, Thomson SA, Colman SD, Abernathy CR, Trimpert RE, Moose R, Virdi G, Roux K, Bauer M, Rojiani AM, Maria BL, Muir D, Wallace MR. Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis type 1. Genes Chromosomes Cancer. 2000 Aug;28(4):425-31. abstract |
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Abstracts Presented at Meetings during Graduate Studies |
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Moose, R.E., J.C.Clemente, P.O. O'Brien, R.Gan, R.Hemrajani, C.Frase, K.Nash, M.M.Goodenow, and B.M.Dunn. Determining the effectiveness of FIV protease inhibitors against HIV-1 protease wild-type and vriants cloned from a pediatric patient under ritonavir treatment. Federation of American Societies for Experimental Biology 2001. Orlando, FL. April, 2001. |
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Patricia O'Brien, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - May 2003 |
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Dissertation Title |
Effect of pre- and post-therapy mutations on gag-pol polyprotein processing in HIV-1 infected pediatric patients |
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Professional Positions |
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Medical Student, University of Florida College of Medicine |
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Publications |
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Goodenow MM, Bloom G, Rose SL, Pomeroy SM, O'Brien PO, Perez EE, Sleasman JW, Dunn BM. Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag p7(NC) and the C-cleavage site impact Gag-Pol processing by HIV-1 protease. Virology. 2002 Jan 5;292(1):137-49. abstract |
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Tamara C. Otto, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - May 2001 |
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Dissertation Title |
Molecular analysis of F1F0 adenosine triphosphate synthase and renal H+,K+-adenosine triphosphatases |
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Professional Positions |
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Postdoctoral Associate, Department of Biological Chemistry, Division of Endocrinology, The Johns Hopkins University School of Medicine |
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Publications |
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Dowell P, Otto TC, Adi S, Lane MD. Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways. J Biol Chem. 2003 Nov 14;278(46):45485-91. abstract |
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Tang QQ, Otto TC, Lane MD. CCAAT/enhancer-binding protein beta is required for mitotic clonal expansion during adipogenesis. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):850-5. abstract |
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Tang QQ, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):44-9. abstract |
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Jessica Parilla, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - December 2005 |
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Dissertation Title |
Requirements for efficient initiation of poliovirus negative-strand RNA synthesis |
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Professional Positions |
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Education B.S., University of Florida |
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Publications Morasco BJ, Sharma N, Parilla J, Flanegan JB. Poliovirus cre(2C)-dependent synthesis of VPgpUpU is required for positive- but not negative-strand RNA synthesis. J Virol. 2003 May;77(9):5136-44. abstract |
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Stella S. Palii, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 2000 - December 2004 |
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Dissertation Title |
Transcriptional regulation of the human SNAT2 system A amino acid transporter gene by amino acid availability |
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Professional Positions |
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Education |
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M.S., Molecular Cell Biology, State University of Chisinau (Moldova) |
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Publications |
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Palii SS, Chen H, Kilberg MS. Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element. J Biol Chem. 2004 Jan 30;279(5):3463-71. abstract |
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Bain PJ, LeBlanc-Chaffin R, Chen H, Palii SS, Leach KM, Kilberg MS. The mechanism for transcriptional activation of the human ATA2 transporter gene by amino acid deprivation is different than that for asparagine synthetase. J Nutr. 2002 Oct;132(10):3023-9. abstract |
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Abstracts Presented at Meetings during Graduate Studies |
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Honors & Awards |
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Van L. Pineda, Ph.D. |
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Advanced Concentration |
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Mentor |
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Department |
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Enrolled |
August 1998 - August 2003 |
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Dissertation Title |
Regulation of the human asparagine synthetase, p21, and p27 genes by amino acid deprivation (PDF) |
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Professional Positions |
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Postdoctoral Associate, Dept. Cell Biology & Physiology, Washington University, St. Louis, MO |
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Education |
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B.S., Microbiology & Cell Science, University of Florida |
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Publications |
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Barbosa-Tessmann IP, Pineda VL, Nick HS, Schuster SM, Kilberg MS. Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. Biochem J. 1999 Apr 1;339 ( Pt 1):151-8. abstract |
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Martinez A, York SW, Yomano LP, Pineda VL, Davis FC, Shelton JC, Ingram LO. Biosynthetic burden and plasmid burden limit expression of chromosomally integrated heterologous genes (pdc, adhB) in Escherichia coli. Biotechnol Prog. 1999 Sep-Oct;15(5):891-7. abstract |
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